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Interleukin-33: a regulator of basophils
Blood, 2009The cytokine network controlling basophils has been extended to interleukin-33. This commentary provides an update and summary on this emerging concept.
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Interleukin-33 in atopic dermatitis
Journal of Dermatological Science, 2019Atopic dermatitis (AD) is characterized by pruritus, barrier disruption, and inflammationincluding type 2 cytokine production. Interleukin-33 (IL-33) is an inflammatory cytokine that is over-expressed in the keratinocytes of patients with AD. IL-33 transgenic mice, which express IL-33 specifically in keratinocytes, spontaneously develop AD-like eczema,
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Interleukin-33 and oxidative stress in epilepsy patients
Epilepsy Research, 2021İnflammation and oxidative stress plays an important role in the etiology of epilepsy. Interleukin-33 (IL-33), a new member of the cytokine family associated with interleukin-1 (IL-1), has been found to play a role in pathogenesis of central nervous system diseases and cause the production of proinflammatory cytokines and oxidative stress molecules ...
Ozlem Ethemoglu +6 more
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Tranilast inhibits interleukin-33 production by macrophages
European Journal of Pharmacology, 2018Tranilast is an anti-allergy medication that inhibits the release of chemical mediators such as histamine. However, the mechanisms underlying its anti-allergy effects are not fully understood. Interleukin (IL)-33, a novel member of the IL-1 cytokine family, promotes T helper type 2 immune responses and plays a pathogenic role in allergic disorders.
Sachiko, Hiraide +2 more
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Interleukin-33 as a New Marker of Pulmonary Sarcoidosis
2015The mechanisms of sarcoidosis (Besniera-Boeck-Schaumann disease, BBS) remain incompletely understood, although recent observations suggested an important contribution of interleukin-33 (IL-33). So far, there are no data about bronchoalveolar lavage fluid (BALF) concentration of IL-33 in patients with BBS. In the present study we attempted to relate the
W, Naumnik +4 more
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Upregulation of Interleukin-33 in obstructive renal injury
Biochemical and Biophysical Research Communications, 2016Interstitial fibrosis and loss of parenchymal tubular cells are the common outcomes of progressive renal diseases. Pro-inflammatory cytokines have been known contributing to the damage of tubular cells and fibrosis responses after renal injury. Interleukin (IL)-33 is a tissue-derived nucleus alarmin that drives inflammatory responses.
Wei-Yu Chen +6 more
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Interleukin 33 is a guardian of barriers and a local alarmin
Nature Immunology, 2016Interleukin 33 (IL-33) is a member of the IL-1 family of cytokines with a growing number of target cells and a plethora of biological functions. Although it has commonalities with other IL-1 cytokines, IL-33 exhibits some unique features. Here we review the biology of IL-33 and its receptor and develop a working model that describes two 'lives' for IL ...
Nikolas T, Martin, Michael U, Martin
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Interleukin-33 and the function of innate lymphoid cells
Trends in Immunology, 2012Interleukin (IL)-33 is a member of the IL-1 cytokine family that has been shown to play an important role in the induction and effector phases of type 2 immune responses. Both innate and adaptive immunity are regulated by IL-33, and many studies have shown disease-associated functions for this cytokine.
Mirchandani, Ananda S. +2 more
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Interleukin-33: increasing role in dermatological conditions
Archives of Dermatological Research, 2016Interleukin-33 is a novel and an unconventional member of IL-1 family. It is an inflammation-induced factor with dual function exercising its role as an intracellular regulator of gene expression, as well as, an extracellular alarm mediator. It is a ligand for ST2, a heterodimeric membrane-bound receptor of the orphan IL-1 family receptor.
Balato, Anna +4 more
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Role of interleukin 33 in respiratory allergy and asthma
The Lancet Respiratory Medicine, 2014Since the discovery of interleukin 33 as the adopted ligand for the then orphan ST2 receptor, many studies have implicated this cytokine in the pathogenesis of respiratory allergy and asthma. Although some extracellular functions of interleukin 33 have been well defined, many aspects of the regulation and secretion of this cytokine need clarification ...
Heidi, Makrinioti +4 more
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