Interleukin-33 - Open Access .click

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Interleukin 33 is a guardian of barriers and a local alarmin

Nature Immunology, 2016
Interleukin 33 (IL-33) is a member of the IL-1 family of cytokines with a growing number of target cells and a plethora of biological functions. Although it has commonalities with other IL-1 cytokines, IL-33 exhibits some unique features. Here we review the biology of IL-33 and its receptor and develop a working model that describes two 'lives' for IL ...
Nikolas T, Martin, Michael U, Martin
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Role of interleukin 33 in respiratory allergy and asthma

The Lancet Respiratory Medicine, 2014
Since the discovery of interleukin 33 as the adopted ligand for the then orphan ST2 receptor, many studies have implicated this cytokine in the pathogenesis of respiratory allergy and asthma. Although some extracellular functions of interleukin 33 have been well defined, many aspects of the regulation and secretion of this cytokine need clarification ...
Heidi, Makrinioti +4 more
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Interleukin-33: A new frontier in cancer immunotherapy

Interleukin (IL)-33 is a member of the IL-1 cytokine family that is involved in critical physiological functions. IL-33 is constitutively expressed in the nucleus of many cell types and participates in gene regulation. However, during inflammation, IL-33 is released by cells to promote an immune response and favor tissue repair. Often referred to as an
Kaur, Amrita +9 more
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Interleukins in Cancer: From Biology to Therapy

Nature Reviews Cancer, 2021
Peter Libby, Daria Briukhovetska, Stefan Endres +2 more
exaly

Targeting interleukin-33 in rheumatoid arthritis