Results 121 to 130 of about 20,065,044 (264)

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

AI-driven multi-omics drug repurposing nominates AZD7762 as a multitarget inhibitor of IL22RA1 and FAM221A in esophageal squamous cell carcinoma

npj Precision Oncology
Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with limited targeted treatment options and poor clinical outcomes. We developed an AI-driven multi-omics pipeline that links prognostic modeling to multitarget drug repurposing for ...
Zhan Zhuang, Shaobin Yu, Kaiming Peng, Peipei Zhang, Jingchuan Yu, Jihong Lin, Mingqiang Kang   +6 more
doaj   +1 more source

Insulin Resistance Mediates the Association Between Vitamin D and Non-Alcoholic Fatty Liver Disease

International Journal of Preventive Medicine
Background: Vitamin D (VD) deficiency and insulin resistance (IR) increase the risk of non-alcoholic fatty liver disease (NAFLD), but few studies have explored the potential mechanisms by which IR mediates the association between VD and the pathogenesis ...
Caiyan Zou, Xuekui Liu, Maosheng He, Yan Sun, Yiquan Sang, Gangshan Peng, Yamei Ma, Houfa Geng, Jun Liang   +8 more
doaj   +1 more source

Interleukin-3 Receptor Subunit Alpha [PDF]

, 2020
openaire   +1 more source

Estudo da atividade antiinflamatória dos ligantes do receptor periférico dos benzodiazepínicos: Pk11195 e Ro5-4864 [PDF]

, 2001
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências BiológicasO tratamento in vivo em camundongos com ligantes do receptor periférico benzodiazepínico (PBR) exerceram efeito inibitório na resposta inflamatória em dois ...
Torres, Sandra Regina Rachadel
core  

Adenosine monophosphate–activated protein kinase activation is associated with suppression of NLRP3 inflammasome–mediated neuroinflammation in a weight‐drop model of traumatic brain injury in Sprague–Dawley rats

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the study's schematic model. Adenosine monophosphate–activated protein kinase (AMPK) activators exhibited neuroprotection in the weight‐drop model of traumatic brain injury by improving cognition and regulating oxidative stress, microglial activation, and nucleotide‐binding oligomerization domain, leucine‐rich repeat,
Triveni Kodi, Paka Sravan Kumar, Krishnadas Nandakumar, Anoop Kishore   +3 more
wiley   +1 more source

IL‐2Rα is a potential biomarker for heart failure diagnosis of patients with end‐stage renal disease and haemodialysis

ESC Heart Failure
Aims Heart failure (HF) is a leading cause of mortality in patients with end‐stage renal disease (ESRD) undergoing haemodialysis. Identifying novel predictors of HF is essential for improving diagnostic precision and enhancing patient outcomes.
Bingya Lv, Zhe Wang, Ya Suo, Shuai Shao, Meng Yuan, Yue Zhang, Lihua Wang, Guangping Li, Qiankun Bao   +8 more
doaj   +1 more source

Interleukin-3 Receptor Subunit Alpha Positive [PDF]

, 2020
openaire   +1 more source

Purification and characterization of heterologously produced cannabinoid receptor 1 and G proteins [PDF]

, 2007
G protein coupled receptors form the largest group of transmembrane proteins, which are involved in signal transduction and are targeted directly or indirectly by 40-50% of the drugs in the market.
Chillakuri, Chandramouli, Chillakuri, C.
core  

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source