Results 171 to 180 of about 20,065,044 (264)

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

What is new on the horizon for the biologics world: New kids of the block - WAO state of art. [PDF]

World Allergy Organ J
Canonica GW, Ortega-Martell JA, Villarreal-González RV, Ansotegui IJ, Bachert C, Bernstein J, Bleecker E, Bondi B, Caminati M, Carr T, Cianferoni A, González ID, Díaz SG, Gómez RM, Hanania N, Heffler E, Nair P, Öztop N, Park HS, Pitè H, Rouadi P, Saito H, Triggiani M, Varricchi G, Virchow C, Yamada Y, Yáñez A, Morais-Almeida M.   +27 more
europepmc   +1 more source

Polyphenol dietary supplementation prevents inflammation‐induced muscle atrophy in a zebrafish (Danio rerio) model

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Diet‐induced inflammation is a major cause of muscle degeneration impacting human and animal health. Owing to their anti‐inflammatory and antioxidant properties, polyphenols have attracted considerable interest as feed additives.
Graziella Orso, Monica Matuozzo, Mariapina Rocco, Seyed Hossein Hoseinifar, Ghasem Ashouri, Andrea Scaloni, Marina Paolucci, Chiara D'Ambrosio, Roberta Imperatore   +8 more
wiley   +1 more source

Paradoxical Alopecia Areata Induced by IL‐17 and IL‐23 Inhibitors: A Systematic Review

JEADV Clinical Practice, EarlyView.
This systematic review identifies consistent clinical patterns of alopecia areata associated with IL‐17 and IL‐23 inhibitors, most frequently involving secukinumab and ustekinumab. Disease severity varied widely, and management often required biologic discontinuation or therapeutic switching.
Isabella Kamholtz, Simonetta I. Gaumond, Joaquin J. Jimenez   +2 more
wiley   +1 more source

Prolonged high-density culture with restricted medium renewal induces epithelial-like plasticity in apical papilla stem cells. [PDF]

Biomol Biomed
Kercheva K, Miteva M, Kalenderova S, Mitev V, Mihaylova Z, Ishkitiev N, Dimitrova VS.   +6 more
europepmc   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

Cellular Senescence in Blood Cells: A Link Between Metabolic Syndrome, Inflammaging and Cardiometabolic Disease. [PDF]

Cells
Gioti K, Trapali M, Belouka I, Chaniotis D, Beloukas A.   +4 more
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Cytokine fusion proteins for solid tumor therapy: mechanistic insights and clinical advances. [PDF]

J Hematol Oncol
Wang Y, Zheng J, Li Z, Qu J, Ren Y, Cai Z, Li Y, Sun W, Jiang N, Cai C, Ruan K, Shi J, Zhang Z, Zhou J.   +13 more
europepmc   +1 more source