Results 61 to 70 of about 20,065,044 (264)

Trypanosomiasis-induced Th17-like immune responses in carp [PDF]

, 2010
Background - In mammalian vertebrates, the cytokine interleukin (IL)-12 consists of a heterodimer between p35 and p40 subunits whereas interleukin-23 is formed by a heterodimer between p19 and p40 subunits.
B M Lidy Verburg-van Kemenade, Verburg-van Kemenade, B.M.L., Chadzinska Magdalena, Wiegertjes Geert F., Chadzinska, M.K., Huub F. J. Savelkoul, Scheer Marleen, Savelkoul, H.F.J., Scheer, M.H., Geert F Wiegertjes, Savelkoul Huub F. J., Bird, S., Maria J. S. L. Pontes, Ribeiro, Carla M. S., B. M. Lidy Verburg-van Kemenade, Wiegertjes, G.F., Savelkoul, Huub F. J., Carla M S Ribeiro, Scheer, Marleen, Marleen Scheer, Verburg-van Kemenade B. M. Lidy, Steve Bird, Maria J S L Pontes, Huub F J Savelkoul, Pontes, Maria J. S. L., Verburg-van Kemenade, B. M. Lidy, Ribeiro, C.M.S., Wiegertjes, Geert F., Bird Steve, Magdalena Chadzinska, Carla M. S. Ribeiro, Pontes, M.J.S.L., Ribeiro Carla M. S., Chadzinska, Magdalena, Pontes Maria J. S. L., Bird, Steve, Geert F. Wiegertjes   +36 more
core   +2 more sources

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

UPLC-Q-TOF/MS, network pharmacology, molecular docking, and experimental validation to explore the mechanisms of toad clothing on rheumatoid arthritis

Scientific Reports
Toad clothing (toad slough) detoxifies, reduces oedema and analgesia, is anti-inflammatory and anti-tumour, and regulates the immune system. Toad clothing’s mechanism is unclear.
Ting Wang, Haixiong Xia, Jingyi Zhu, Mingyou Yu, Ziyi Zhang, Junhou Lu, Wei Zhou, Jianwei Xu   +7 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes [PDF]

, 2006
Background: PPARs exhibit anti-inflammatory capacities and are potential modulators of the inflammatory response. We hypothesized that their expression and/or function may be altered in cystic fibrosis (CF), a disorder characterized by an excessive host ...
Wagner, Thomas, Reynders, Veerle, Veerle Reynders, Stefan Loitsch, Joachim Bargon, Reynders Veerle, Thomas Wagner, Steinhauer, Constanze, Bargon Joachim, Steinhilber Dieter, Bargon, Joachim, Loitsch Stefan, Dieter Steinhilber, Constanze Steinhauer, Loitsch, Stefan Marcel, Wagner Thomas, Steinhauer Constanze, Steinhilber, Dieter   +17 more
core   +2 more sources

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner. [PDF]

, 2009
Translocation of the Helicobacter pylori (Hp) cytotoxin-associated gene A (CagA) effector protein via the cag-Type IV Secretion System (T4SS) into host cells is a major risk factor for severe gastric diseases, including gastric cancer.
Haas, Rainer, Rainer Haas, Kapp, Ulrike, Jung, Kirsten, Kirsten Jung, Rohde, Manfred, Claudia Ertl, Retta, S. Francesco, S. Francesco Retta, Terradot Laurent, Ertl, Claudia, Luisa F. Jiménez-soto, Luisa F Jiménez-Soto, Fischer Rainer Haas, Retta S. Francesco, Pirch Torsten, Weiss, Evelyn, Xaver Sewald, Jiménez-Soto Luisa F., Wolfgang Fischer, Ertl Claudia, Evelyn Weiss, Jiménez-Soto, Luisa F., Fischer, Wolfgang, Weiss Evelyn, Manfred Rohde, Kutter, Stefan, Kutter Stefan, Pirch, Torsten, Terradot, Laurent, Sewald, Xaver, Fischer Wolfgang, Torsten Pirch, Laurent Terradot, S Francesco Retta, Haas Rainer, Rohde Manfred, Kapp Ulrike, Ulrike Kapp, Retta, Saverio Francesco, Stefan Kutter, Jung Kirsten, Sewald Xaver   +42 more
core   +2 more sources

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source

Upregulation of alpha 7 nicotinic receptors by acetylcholinesterase c-terminal peptides [PDF]

, 2009
Background: The alpha-7 nicotinic acetylcholine receptor (alpha 7-nAChR) is well known as a potent calcium ionophore that, in the brain, has been implicated in excitotoxicity and hence in the underlying mechanisms of neurodegenerative disorders such as ...
Bond, Cherie E., Cherie E Bond, Greenfield Susan A., Susan A Greenfield, Greenfield, SA, Martina Zimmermann, Zimmermann, M, Bond Cherie E., Greenfield, Susan A, Bond, CE, Zimmermann Martina, Greenfield, Susan A., Bond, Cherie E, Zimmermann, Martina, Greenfield, Susan   +14 more
core   +2 more sources

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Identification of the immune-related biomarkers in Behcet’s disease by plasma proteomic analysis

Arthritis Research & Therapy, 2023
Background This study aimed to investigate the expression profile of immune response-related proteins of Behcet’s disease (BD) patients and identify potential biomarkers for this disease. Methods Plasma was collected from BD patients and healthy controls
Huan Liu, Panpan Zhang, Fuzhen Li, Xiao Xiao, Yinan Zhang, Na Li, Liping Du, Peizeng Yang   +7 more
doaj   +1 more source