Results 191 to 200 of about 705,101 (300)

A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: Unveiling a novel virulence factor. [PDF]

PLoS Pathog
Volkening JD, Spatz SJ, Garcia M, Ross TA, Maekawa DA, Rosenthal KS, Zamora AC, Skipper A, Blakey JR, Paudel R.   +9 more
europepmc   +1 more source

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, EarlyView.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source

Genetic Deficiency of Interleukin-4 and Interleukin-13 Exacerbates Alcohol- and Cigarette Smoke-Associated Chronic Pancreatitis via the Pancreas-Intestine Axis. [PDF]

Gastro Hep Adv
Wang J, Shams Azar PR, Apte MV, Pandol SJ, Husain SZ, Lee B.   +5 more
europepmc   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

Immunity

Emerging Infectious Diseases, 2016
Theodore M. Lee
doaj   +1 more source

S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis. [PDF]

Immunity
Das M, Alasharee M, Woods B, Mukherjee S, Kim S, Elkins M, Ngo J, Magin L, Timilshina M, Leyva-Castillo JM, Murphy KM, Anthony RM, Laureano AFS, Murphy GF, McNamee S, Brombacher F, Hogan SP, Turner JR, Abtahi S, Phipatanakul W, Leung DYM, Goleva E, Oettgen HC, Li M, Chou J, Schlievert PM, Finkelman FD, Geha RS.   +27 more
europepmc   +1 more source

Irgm1 Improves Postinfarction Cardiac Repair by Promoting Neutrophil Clearance and Efferocytosis

Advanced Science, EarlyView.
The Irgm1‐PDIA3 axis enhances post‐infarction cardiac repair by accelerating neutrophil clearance and facilitating efferocytosis. Irgm1 holds potential as a prognostic biomarker in MI, and LOC14 may represent a therapeutic option to improve cardiac repair, especially in cases of Irgm1 deficiency.
Zeng Wang, Lai Wei, Mingyang Wang, Shanjie Wang, Lili Xiu, Jiaxiang Sun, Rongzhe Lu, Yige Liu, Jiaxin Wang, Fengyi Liu, Weike Liu, Bo Yu, Yong Sun, Xueqin Gao, Shaohong Fang   +14 more
wiley   +1 more source

The E3 ligases Itch and WWP2 regulate autoimmune neuroinflammation by controlling T_H2 to T_H17 cell conversion via interleukin-4-STAT5 axis in mice. [PDF]

Nat Commun
Zhao M, Zhang C, Zhang X, Mu Q, Li Q, Liu YC.   +5 more
europepmc   +1 more source

Interleukin 4 Measurement [PDF]

, 2020
openaire   +1 more source