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Younger severe asthma patients with interleukin 4 (CC variant) and dupilumab treatment are more likely to achieve clinical remission. [PDF]
BMC Pulm MedAl-Ahmad M, Ali A, Talat W.
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Monocyte-derived Langerhans cells express Delta-like 4 induced by peptidoglycan and interleukin-4 mediated suppression. [PDF]
Front ImmunolOno R, Maeda K, Tanioka T, Isozaki T.
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Interleukin-4 and Interleukin-17 are associated with coronary artery disease. [PDF]
Clin CardiolWang C +13 more
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Functional interleukin-4 releasing microparticles impact THP-1 differentiated macrophage phenotype. [PDF]
Front Bioeng BiotechnolLee IN, Stening JZ, Rose FRAJ, White LJ.
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International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1990
Since its discovery in 1982, numerous biological activities of interleukin-4 (IL-4) have been described. Like other cytokines, IL-4 is highly pleiotropic, both with respect to the number of different target cells that are responsive to it and with respect to the number of different biological responses it elicits.
J H, Jansen +3 more
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Since its discovery in 1982, numerous biological activities of interleukin-4 (IL-4) have been described. Like other cytokines, IL-4 is highly pleiotropic, both with respect to the number of different target cells that are responsive to it and with respect to the number of different biological responses it elicits.
J H, Jansen +3 more
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Immunological Reviews, 1997
Summary: Experimental infection of mice with Listeria monocytogenes (L. monocytogenes) has served as an appropriate model for analyzing Thl nil driven immune responses. Generally, Th2 responses are absent and IL‐4 is not detectable. Here, we describe experimental settings under which IL‐4 is detectable in listeriosis.
Kaufmann, S. +4 more
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Summary: Experimental infection of mice with Listeria monocytogenes (L. monocytogenes) has served as an appropriate model for analyzing Thl nil driven immune responses. Generally, Th2 responses are absent and IL‐4 is not detectable. Here, we describe experimental settings under which IL‐4 is detectable in listeriosis.
Kaufmann, S. +4 more
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Interleukin‐4 and the interleukin‐4 receptor in allergic contact dermatitis
Contact Dermatitis, 1998Cutaneous immune responses involving T helper (TH) type 1 (TH1) and type 2 (TH2) T cells, characterised by secretion of interferon‐γ (Ifn‐γ) and interleukin‐4 (IL‐4), respectively, have both been reported in allergic contact dermatitis (ACD). We used immunohistochemistry to localize expression of IL‐4 in ACD lesions and unaffected skin.
A, Rowe, C B, Bunker
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Regulation of Interleukin 4 Production and of Interleukin 4-Producing Cells
International Archives of Allergy and Immunology, 2009Interleukin 4 (IL-4) is a cytokine with a broad range of functions on immune cells including the stimulation of IgE synthesis by B cells. IL-4 is synthesized by freshly isolated T cells following appropriate stimulation with either lectins or antibodies against selected surface antigens.
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Interleukin-4 as a therapeutic target
Pharmacology & Therapeutics, 2023Interleukin-4 (IL-4) is a pleiotropic cytokine mainly known for its role in type 2 immunity. Therapies antagonizing or blocking IL-4 activity have been developed to counteract diseases such as atopic dermatitis and asthma. In contrast, other disorders experimentally benefit from IL-4-related effects and IL-4 recently demonstrated beneficial activity in
Yvonne, Gärtner +3 more
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