Results 51 to 60 of about 719,716 (198)

Interleukin-4 and its receptor alpha in paediatric uncomplicated malaria patients from a Ghanaian case-control study

BMC Research Notes
Objectives This study investigated gene polymorphisms in the interleukin-4 (IL-4) and its receptor alpha (IL-4Rα) gene regions in human hosts with uncomplicated malaria.
Patrick Diaba-Nuhoho
doaj   +1 more source

Interleukin-4-Enhanced Oligodendrocyte Differentiation Depends on Extracellular Zinc Uptake via ZIP11

Cells
Differentiation of oligodendrocytes and myelination are enhanced by interleukin-4, an anti-inflammatory cytokine secreted from immune cells or injured neurons, and peroxisome proliferator-activated receptor γ serves as a central effector.
Takaaki Aratake, Serika Kurita, Michael Wegner   +2 more
doaj   +1 more source

The effect of exercise on plasma soluble IL-6 receptor concentration: a dichotomous response [PDF]

, 2010
The aim of this article is to review current literature on the response of soluble interleukin-6 receptor to exercise and identify a potential role for sIL-6R in skeletal muscle function.
Cockburn, Emma, Nimmo, Myra, Robson-Ansley, Paula, Stevenson, Emma, Walshe, Ian   +4 more
core  

The role of the novel Th17 cytokine IL-26 in intestinal inflammation [PDF]

, 2008
Background and aims: Interleukin 26 (IL-26), a novel IL-10-like cytokine without a murine homologue, is expressed in T helper 1 (Th1) and Th17 cells. Currently, its function in human disease is completely unknown. The aim of this study was to analyse its
Auernhammer, Christoph J., Beigel, Florian, Brand, Stephan, Dambacher, J., Diepolder, Helmut M., Göke, Burkhard, Toni, Enrico N. de, Zitzmann, K.   +7 more
core   +1 more source

Successful treatment of recalcitrant generalized pustular psoriasis in a young child with interleukin-36 receptor antagonist mutation with secukinumab monotherapy

Indian Journal of Paediatric Dermatology, 2021
Generalized pustular psoriasis (GPP) is a severe, life-threatening form of psoriasis. Deficiency of interleukin (IL)-36 receptor antagonist has been found in a subset of patients with GPP, which is usually more difficult to treat with conventional ...
Henrietta Albela, Sabeera Begum, Kin Fon Leong   +2 more
doaj   +1 more source

Activated γδ T cells inhibit osteoclast differentiation and resorptive activity in vitro [PDF]

, 2013
Peer reviewedPublisher ...
Pappalardo, A., Thompson, K.
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Short-Term Evaluation of Dupilumab Effects in Patients with Severe Asthma and Nasal Polyposis

Journal of Asthma and Allergy, 2021
Corrado Pelaia,1 Nicola Lombardo,2 Maria Teresa Busceti,1 Giovanna Piazzetta,2 Claudia Crimi,3 Cecilia Calabrese,4 Alessandro Vatrella,5 Girolamo Pelaia1 1Department of Health Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy; 2Department
Pelaia C, Lombardo N, Busceti MT, Piazzetta G, Crimi C, Calabrese C, Vatrella A, Pelaia G   +7 more
doaj  

Induction of IL 2 receptor expression and cytotoxicity of thymocytes by stimulation with TCF1 [PDF]

, 1985
We investigated the role of T cell cytotoxicity inducing factor 1 (TCF1) in the induction of a cytotoxic T cell response. We found that help-deficient thymocyte cultures supplied with saturating amounts of purified IL 2 did not develop CTL in a 5-day ...
Diamantstein, T., Dröge, W., Falk, Werner, Kaltmann, B., Katzer, B., Krammer, P. H., Männel, D. N.   +6 more
core  

New interleukin-15 superagonist (IL-15SA) significantly enhances graft-versus-tumor activity. [PDF]

, 2017
Interleukin-15 (IL-15) is a potent cytokine that increases CD8+ T and NK cell numbers and function in experimental models. However, obstacles remain in using IL-15 therapeutically, specifically its low potency and short in vivo half-life.
Alpdogan, Onder, Bailey, Cavan P, Budak-Alpdogan, Tulin, Buyukgoz, Cihangir, Flomenberg, MD, Neal, Jeng, Emily K, Panis, Michelle M, Sauter, Christopher T, Wong, Hing C   +8 more
core   +3 more sources

An IL-4/21 Inverted Cytokine Receptor Improving CAR-T Cell Potency in Immunosuppressive Solid-Tumor Microenvironment

Frontiers in Immunology, 2019
Incorporation of inverted cytokine receptor (ICR) such as interleukin (IL)-4 vs. IL-7 (4/7) ICR is one strategy to improve the antitumor activities of chimeric antigen receptor (CAR) modified T (CAR-T) cells facing immunosuppressive cytokines.
Yi Wang, Hua Jiang, Hong Luo, Yansha Sun, Bizhi Shi, Ruixin Sun, Zonghai Li, Zonghai Li   +7 more
doaj   +1 more source