Results 161 to 170 of about 79,526,962 (296)

Creatine kinase levels in asthma patients receiving interleukin-5 therapy. [PDF]

Ther Adv Respir Dis, 2022
Kavanagh GA, Casey D, Cusack RP, Plant BJ, Murphy DM.   +4 more
europepmc   +1 more source

Interleukin-5, eosinophils, and disease [PDF]

Blood, 1992
openaire   +3 more sources

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Effects of β-1.3/1.6 glucan on cytokines production by leukocytes in vitro

Open Medicine, 2012
Sakalauskiene Jurgina, Akramas Laimis, Gleiznys Alvydas, Kubilius Ricardas, Vitkauskiene Astra, Surna Algimantas, Junevicius Jonas   +6 more
doaj   +1 more source

Therapeutic Efficacy of Anti-Interleukin-5 Monoclonal Antibodies in Kimura Disease: A Systematic Review. [PDF]

Cureus
Olizarowicz S, Mierzejewski M, Majewski M, Szczepanska P.   +3 more
europepmc   +1 more source

Interleukin-5 receptor alpha (CD125) expression on human blood and lung neutrophils. [PDF]

Ann Allergy Asthma Immunol, 2022
Lawrence MG, Teague WG, Feng X, Welch C, Etter E, Negri J, Spano M, Wavell K, Braciale T, Steinke JW, Borish L.   +10 more
europepmc   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Pro-inflammatory and counter-regulatory modulators of interleukin-5-driven eosinophil programs: a framework for precision medicine in eosinophilic diseases. [PDF]

Front Immunol
Sasaki H, Miyata J, Fukunaga K.
europepmc   +1 more source

Real-World Clinical Outcomes in Asthmatic Patients Switched from Omalizumab to Anti-Interleukin-5 Therapy. [PDF]

J Asthma Allergy, 2022
O'Reilly E, Casey D, Ibrahim H, McGrath A, McHugh T, Vairamani P, Murphy J, Plant B, Murphy DM.   +8 more
europepmc   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source