Results 231 to 240 of about 12,528,653 (292)

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

A Supramolecular Thermal Switch for Precision Pyroptosis via Host−Guest Recognition and Electrostatic Interactions

Advanced Science, EarlyView.
A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu, Jie Zhou, Yibin Cao, Kunmin Ping, Borui Zhao, Yanrong Yang, Chunyang Yu, Xinyang Yu, Shaolong Qi   +8 more
wiley   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

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Interleukin 5

Advances in Neuroimmunology, 1992
Interleukin-5 is a dimeric cytokine that controls the differentiation of B cells into antibody-secreting cells as well as inducing the growth of Ly-1(CD5)+ B cells and B-cell tumors. It also has a major role of the growth and differentiation of eosinophils.
A N, McKenzie, C J, Sanderson
openaire   +4 more sources

Interleukin 5 and its receptor

Progress in Growth Factor Research, 1991
IL-5 is a cytokine mainly produced by T lymphocytes, especially when they are sensitized with microorganisms, which induce eosinophils and Ly-1 positive B lineage cells, both of which are probably engaged in the primary protection against micro-organisms. These possibilities are discussed by analyzing IL-5 transgenic mice.
K, Takatsu, A, Tominaga
openaire   +2 more sources

Interleukin‐5 in eosinophilic gastroenteritis

American Journal of Hematology, 1992
AbstractDuring a 4‐year period a 28‐year‐old female had 4 episodes of eosinophilia of over 10,000/μ1; these episodes were associated with nausea, vomiting, diarrhea, and abdominal pain. On one occasion, she had ascites and pleural effusion which contained numerous mature eosinophils.
T, Takahashi, K, Nakamura, S, Nishikawa, R, Tsuyuoka, A, Suzuki, M, Murakami, M, Amenomori, Y, Okuno, H, Imura   +8 more
openaire   +2 more sources

Interleukin-5: An overview

1995
Interleukin 5 (IL-5) is a cytokine mainly produced by activated T cells upon stimulation with antigen, and by mast cells upon stimulation with allergen/IgE complex or calcium ionophores [1,2]. The study of murine (m) IL-5 originated in the search for T-cell-replacing factor (TRF), which induces 2,4-dinitrophenyl (DNP)-primed B cells to differentiate ...
openaire   +2 more sources

The biological role of interleukin 5

The International Journal of Cell Cloning, 1990
Eosinophilia can be a specific cellular response, but the mechanisms of its control are not yet fully understood. Interleukin 5 (IL-5) is a lineage-specific eosinophil differentiation and activation factor. It can be detected in the serum of mice with eosinophilia, and antibody to IL-5 blocks the development of parasite-induced eosinophilia.
openaire   +2 more sources