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Interleukin 5 and its receptor
Progress in Growth Factor Research, 1991IL-5 is a cytokine mainly produced by T lymphocytes, especially when they are sensitized with microorganisms, which induce eosinophils and Ly-1 positive B lineage cells, both of which are probably engaged in the primary protection against micro-organisms. These possibilities are discussed by analyzing IL-5 transgenic mice.
K, Takatsu, A, Tominaga
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Interleukin‐5 in eosinophilic gastroenteritis
American Journal of Hematology, 1992AbstractDuring a 4‐year period a 28‐year‐old female had 4 episodes of eosinophilia of over 10,000/μ1; these episodes were associated with nausea, vomiting, diarrhea, and abdominal pain. On one occasion, she had ascites and pleural effusion which contained numerous mature eosinophils.
T, Takahashi +8 more
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1995
Interleukin 5 (IL-5) is a cytokine mainly produced by activated T cells upon stimulation with antigen, and by mast cells upon stimulation with allergen/IgE complex or calcium ionophores [1,2]. The study of murine (m) IL-5 originated in the search for T-cell-replacing factor (TRF), which induces 2,4-dinitrophenyl (DNP)-primed B cells to differentiate ...
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Interleukin 5 (IL-5) is a cytokine mainly produced by activated T cells upon stimulation with antigen, and by mast cells upon stimulation with allergen/IgE complex or calcium ionophores [1,2]. The study of murine (m) IL-5 originated in the search for T-cell-replacing factor (TRF), which induces 2,4-dinitrophenyl (DNP)-primed B cells to differentiate ...
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The biological role of interleukin 5
The International Journal of Cell Cloning, 1990Eosinophilia can be a specific cellular response, but the mechanisms of its control are not yet fully understood. Interleukin 5 (IL-5) is a lineage-specific eosinophil differentiation and activation factor. It can be detected in the serum of mice with eosinophilia, and antibody to IL-5 blocks the development of parasite-induced eosinophilia.
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Interleukin-5 and Human B Lymphocytes
Methods, 1997Interleukin-5 was initially characterized in murine systems, where it was found to have B-lymphocyte proliferative and differentiative activity and to promote the growth of eosinophils. Recombinant production of human IL-5 was soon accomplished by using murine IL-5 cDNA to isolate the highly homologous human sequence. Although human IL-5 was also found
M A, Baumann, C C, Paul
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Modulation of Eosinophil Chemotaxis by Interleukin-5
American Journal of Respiratory Cell and Molecular Biology, 1992Abstract Eosinophilia and eosinophil function are regulated by cytokines such as granulocyte/macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5). We have investigated the modulatory role of IL-5 on N-formyl-methionyl-leucyl-phenylalanine (FMLP), neutrophil-activating factor (NAF/IL-8 ...
R A, Warringa +5 more
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Gan to kagaku ryoho. Cancer & chemotherapy, 1994
Interleukin-5 (IL-5) is a glycoprotein with molecular weight 40 to 50 kDa that consists of homodimer. The murine cDNA encodes 133 amino acids with a signal sequence of 18 amino acids. The human cD NA codes for a protein with 134 amino acids in which the first 19 are the predicted signal sequence.
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Interleukin-5 (IL-5) is a glycoprotein with molecular weight 40 to 50 kDa that consists of homodimer. The murine cDNA encodes 133 amino acids with a signal sequence of 18 amino acids. The human cD NA codes for a protein with 134 amino acids in which the first 19 are the predicted signal sequence.
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The Biology of Interleukin-5 and Its Receptor
Cancer Investigation, 1993IL-5 is primarily a T-cell-derived cytokine that has multiple regulatory functions on eosinophils and (in the mouse) on antibody-secreting B cells. A complex network of cytokines appear to control transcription of the gene for IL-5 and its production. Abnormally high levels of this cytokine are associated with infections with tissue-dwelling parasites ...
S, Mahanty, T B, Nutman
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Interleukin-5 and the regulation of eosinophil production
Current Opinion in Hematology, 1999Eosinophils play important roles in adaptive immune responses, inflammatory processes, and disease states. Recently, considerable research has been devoted to better defining the normal and abnormal biology of these cells, specifically their origin and mechanisms of stimulation, chemotaxis, regulation, and activation.
G J, Roboz, S, Rafii
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Mutation analysis of interleukin-5 in an asthmatic cohort
Human Mutation, 1998Interleukin-5 (IL-5) is a potential candidate gene in the pathogenesis of asthma, as it is the main cytokine controlling eosinophil activity and eosinophils are pivotal in the development of airway inflammation. Mutation detection studies were performed on the IL-5 gene and the alpha-chain of its receptor in 30 asthmatic and 30 nonasthmatic subjects ...
E, Pereira +4 more
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