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Interleukin-5 and Human B Lymphocytes
Methods, 1997Interleukin-5 was initially characterized in murine systems, where it was found to have B-lymphocyte proliferative and differentiative activity and to promote the growth of eosinophils. Recombinant production of human IL-5 was soon accomplished by using murine IL-5 cDNA to isolate the highly homologous human sequence. Although human IL-5 was also found
M A, Baumann, C C, Paul
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Modulation of Eosinophil Chemotaxis by Interleukin-5
American Journal of Respiratory Cell and Molecular Biology, 1992Abstract Eosinophilia and eosinophil function are regulated by cytokines such as granulocyte/macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5). We have investigated the modulatory role of IL-5 on N-formyl-methionyl-leucyl-phenylalanine (FMLP), neutrophil-activating factor (NAF/IL-8 ...
R A, Warringa +5 more
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Gan to kagaku ryoho. Cancer & chemotherapy, 1994
Interleukin-5 (IL-5) is a glycoprotein with molecular weight 40 to 50 kDa that consists of homodimer. The murine cDNA encodes 133 amino acids with a signal sequence of 18 amino acids. The human cD NA codes for a protein with 134 amino acids in which the first 19 are the predicted signal sequence.
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Interleukin-5 (IL-5) is a glycoprotein with molecular weight 40 to 50 kDa that consists of homodimer. The murine cDNA encodes 133 amino acids with a signal sequence of 18 amino acids. The human cD NA codes for a protein with 134 amino acids in which the first 19 are the predicted signal sequence.
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The Biology of Interleukin-5 and Its Receptor
Cancer Investigation, 1993IL-5 is primarily a T-cell-derived cytokine that has multiple regulatory functions on eosinophils and (in the mouse) on antibody-secreting B cells. A complex network of cytokines appear to control transcription of the gene for IL-5 and its production. Abnormally high levels of this cytokine are associated with infections with tissue-dwelling parasites ...
S, Mahanty, T B, Nutman
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Interleukin-5 and the regulation of eosinophil production
Current Opinion in Hematology, 1999Eosinophils play important roles in adaptive immune responses, inflammatory processes, and disease states. Recently, considerable research has been devoted to better defining the normal and abnormal biology of these cells, specifically their origin and mechanisms of stimulation, chemotaxis, regulation, and activation.
G J, Roboz, S, Rafii
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Mutation analysis of interleukin-5 in an asthmatic cohort
Human Mutation, 1998Interleukin-5 (IL-5) is a potential candidate gene in the pathogenesis of asthma, as it is the main cytokine controlling eosinophil activity and eosinophils are pivotal in the development of airway inflammation. Mutation detection studies were performed on the IL-5 gene and the alpha-chain of its receptor in 30 asthmatic and 30 nonasthmatic subjects ...
E, Pereira +4 more
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Mitogenic effects of interleukin-5 on microglia
Neuroscience Letters, 1995Interleukin-3 (IL-3), interleukin-5 (IL-5), and granulocyte macrophage-colony stimulating factor (GM-CSF) are cytokines that bind to receptor complexes comprised of unique alpha-receptor subunits specific for each ligand and a commonly shared beta-receptor subunit.
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Measurement of Mouse and Human Interleukin 5
Current Protocols in Immunology, 1991AbstractTwo fundamentally different types of assays are available for quantitating interleukin 5 in biological samples. One type, a bioassay, is based on the ability of IL‐5 to enhance B cell proliferation and immunoglobulin secretion or eosinophil proliferation and differentiation.
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Interleukin 5 and B cell differentiation
Cytokine & Growth Factor Reviews, 1998Interleukin-5 (IL-5) stimulates proliferation and differentiation of B cells and eosinophils. IL-5 receptor (IL-5R) comprises alpha and (beta)c chains. IL-5 specifically binds to IL-5Ralpha and induces the recruitment of (beta)c to IL-5Ralpha. JAK2 and JAK1 tyrosine kinases are constitutively associated with hIL-5Ralpha and (beta)c, respectively and ...
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