Results 161 to 170 of about 7,676,359 (302)

Salivary interleukin 6, interleukin 8, interleukin 17A, and tumour necrosis factor α levels in patients with periodontitis and rheumatoid arthritis

Central European Journal of Immunology, 2019
Tomasz Kaczyński, Jakub Wroński, Piotr Głuszko, Tomasz Kryczka, Andrzej Miskiewicz, Bartłomiej Górski, Marek Radkowski, Damian Strzemecki, Paweł Grieb, Renata Górska   +9 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Interleukin-6 is a potent inducer of S100P, which is up-regulated in androgen-refractory and metastatic prostate cancer

, 2005
Interleukin-6 is a potent inducer of S100P, which is up-regulated in androgen-refractory and metastatic prostate ...
ED Williams (9893567), EW Thompson (14472741), A Hammacher (21767195)   +2 more
core  

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

Differential regulation of interleukin-17 and interferon-y production in inflammatory bowel disease

, 2010
PhDBackground and Aims. Interleukin (IL)-17 is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel disease (IBD) are still unclear. Methods.
Rovedatti, Laura
core  

Interleukin-6 in Natural and Pathophysiological Kidney Aging. [PDF]

Cells
Mutig K, Singh PB, Lebedeva S.
europepmc   +1 more source

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates.

, 2019
BACKGROUND: The Asp358Ala variant (rs2228145; A>C) in the interleukin-6 receptor ( IL6R) gene has been implicated in the development of abdominal aortic aneurysms (AAAs), but its effect on AAA growth over time is not known.
A Finigan (7786799), C Grenier (7786796), JS Lindholt (7786808), J Powell (7598840), E Paige (7785113), J Raffort (7786793), BB Sun (7786805), MA Bailey (7786820), F Lareyre (7786790), SC Harrison (7696958), DS Paul (7786829), AS Butterworth (7675697), PE Norman (7635392), IJ Kullo (7786814), MJ Bown (7696970), J Harrison (7119110), DF Freitag (7786826), JE Peters (7786802), J Danesh (7635188), M Clément (7786787), M Sweeting (7714721), SA Badger (7786811), S Rose-John (7786823), Z Mallat (7672571), JA Scott (7786817)   +24 more
core  

Interleukin-6 as a predictive biomarker of systemic progression and therapeutic target in cutaneous plasmacytosis. [PDF]

An Bras Dermatol
Hong YY, Chen PY, New HT, Cai SQ.
europepmc   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source