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Interleukin-6: A Masterplayer in the Cytokine Network
Oncology, 2020Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the expression of a variety of proteins responsible for acute inflammation, and plays an important role in the proliferation and differentiation of cells in humans.
P. Uciechowski, W. Dempke
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Targeting Interleukin-6 Signaling in Clinic.
Immunity, 2019Interleukin-6 (IL-6) is a pleiotropic cytokine with roles in immunity, tissue regeneration, and metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue injury, but excessive synthesis of IL-6 and dysregulation of IL-6
Sujin Kang +3 more
semanticscholar +1 more source
Current Opinion in Hematology, 2001
Strenuous exercise induces increased levels in a number of pro-and anti-inflammatory cytokines, natural occurring cytokine inhibitors, and chemokines. Thus, increased plasma levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-1 receptor antagonist (IL-1ra), TNF-receptors (TNF-R), IL-10, IL-8, and macrophage inflammatory protein ...
B K, Pedersen +2 more
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Strenuous exercise induces increased levels in a number of pro-and anti-inflammatory cytokines, natural occurring cytokine inhibitors, and chemokines. Thus, increased plasma levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-1 receptor antagonist (IL-1ra), TNF-receptors (TNF-R), IL-10, IL-8, and macrophage inflammatory protein ...
B K, Pedersen +2 more
openaire +2 more sources
Interleukin-6-Producing Pheochromocytoma
Acta Haematologica, 1991A 42-year-old female with high fever and headache was admitted. Physical examination revealed hypertension, thrombocytosis with megakaryocytosis, hyperfibrinogenemia, and high level of serum noradrenaline. After operation of extramedullary pheochromocytoma, all symptoms disappeared and findings became normal.
K, Suzuki +6 more
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Current Protocols in Immunology, 1996
AbstractInterleukin 6 (IL‐6) is a pluripotent cytokine with multiple effects on many different cell types. It is produced by a variety of cells in response to immunological and other stimuli. This unit describes a simple and sensitive assay for human, rat, rabbit, pig, and mouse IL‐6, based on IL‐6‐dependent proliferation of a murine B cell hybridoma ...
R P, Nordan, C D, Richards, J, Gauldie
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AbstractInterleukin 6 (IL‐6) is a pluripotent cytokine with multiple effects on many different cell types. It is produced by a variety of cells in response to immunological and other stimuli. This unit describes a simple and sensitive assay for human, rat, rabbit, pig, and mouse IL‐6, based on IL‐6‐dependent proliferation of a murine B cell hybridoma ...
R P, Nordan, C D, Richards, J, Gauldie
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Role of Interleukin-6 in Development of Insulin Resistance and Type 2 Diabetes Mellitus.
Critical Reviews in Eukaryotic Gene Expression, 2017Interleukin-6 (IL-6) is a proinflammatory cytokine that decisively induces the development of insulin resistance and pathogenesis of type 2 diabetes mellitus (T2DM) through the generation of inflammation by controlling differentiation, migration ...
K. Rehman +5 more
semanticscholar +1 more source
Melanoma Research, 2012
Interleukin-6 (IL-6) is a pleiotropic immunomodulatory cytokine produced by various types of cells, including melanoma cells. IL-6 plays a major role in the pathogenesis and development of malignancies. It promotes tumour growth by inhibition of apoptosis and induces tumour angiogenesis. IL-6 is deregulated in many types of cancers, and increased serum
Hoejberg, Lise +2 more
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Interleukin-6 (IL-6) is a pleiotropic immunomodulatory cytokine produced by various types of cells, including melanoma cells. IL-6 plays a major role in the pathogenesis and development of malignancies. It promotes tumour growth by inhibition of apoptosis and induces tumour angiogenesis. IL-6 is deregulated in many types of cancers, and increased serum
Hoejberg, Lise +2 more
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Interleukin-6 Inhibitor: Tocilizumab
2015Inhibitors of interleukin-6 (IL-6) are proteins which decrease the actions of the inflammatory cytokine, IL-6. Clinically, tocilizumab is the major inhibitor of IL-6. Several other proteins with IL-6 inhibitory actions (e.g., sirukumab) are being tested in clinical trials.
Pile, Kevin D. +2 more
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Cardiovascular Biology of Interleukin-6
Current Pharmaceutical Design, 2009Interleukin-6 (IL-6) is a multifunctional pro-inflammatory cytokine that is tightly regulated and expressed at low levels in healthy individuals. Increased IL-6 expression has been associated with a variety of diseases, including inflammatory conditions such as atherosclerosis and cardiovascular disease (obesity, myocardial infarction and type II ...
Mahinda Y, Abeywardena +4 more
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Interleukin-6 in atherosclerosis: atherogenic or atheroprotective?
Clinical Lipidology, 2017Interleukin-6 (IL-6) is a unique pleiotropic cytokine exhibiting both pro- and anti-inflammatory properties depending on the target cell type. Plasma IL-6 levels are associated with cardiovascular risk.
A. Reiss, Nicolle M. Siegart, J. De Leon
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