Results 191 to 200 of about 10,290,985 (290)

Genomic Profile of Interleukin-6 Secreting Ovarian Cancer: Validation of Future Biomarkers and Target of Therapy. [PDF]

Int J Womens Health
Zucha MA, Budhyanto VSW, Priadi WA, Tirtasari FD, Fahmi MN, Trirahmanto A, Kusumanto A, Pradjatmo H, Salima S, Harsono AB, Winarno GNA, Suardi D, Yasmine N, Wicaksono AW, Paulus LD, Yusuf M, Kurniadi A.   +16 more
europepmc   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Role of Interleukin-6 in Atherothrombosis and Myocardial Infarction. [PDF]

Curr Atheroscler Rep
Huse C, Gregersen I, Holme FA, Ueland T, Skjelland M, Aamodt AH, Dahl TB, Aukrust P, Halvorsen B.   +8 more
europepmc   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Interleukin-6 stimulates platelet 12-lipoxygenase to drive coagulation in inflammatory arthritis. [PDF]

J Lipid Res
Costa DO, Hughes STO, Jenkins RH, Figueras AC, Protty MB, Tyrrell VJ, Hajeyah AA, Jones GW, Burston JJ, Morgan B, Monaco F, Hill D, Morrin AS, Guy C, Bacon A, Giera M, Toes REM, Jenkins PV, Collins PW, Choy E, Jones SA, O'Donnell VB.   +21 more
europepmc   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Special issue on Interleukin-6 (IL-6)

International Journal of Biological Sciences, 2012
Mercedes Rincon
doaj  

Interleukin-6 as a predictive biomarker of systemic progression and therapeutic target in cutaneous plasmacytosis. [PDF]

An Bras Dermatol
Hong YY, Chen PY, New HT, Cai SQ.
europepmc   +1 more source

Hollow Cu2O Nanozymes Enhance Probiotic Therapy for Colitis via Redox Homeostasis and TXNIP/NLRP3 Inflammasome Inhibition

Advanced Science, EarlyView.
Hollow cuprous oxide (H‐Cu2O) nanozymes feature enlarged catalytic surfaces for superior reactive oxygen species (ROS) scavenging. By efficiently neutralizing mucosal ROS, H‐Cu2O directly suppresses the TXNIP/NLRP3 inflammasome axis and restores intestinal epithelial barrier integrity.
Guangzhao Wang, Jialing Cao, Pengfei Li, Yujie Wang, Shiqi Lu, Kangliang Sheng, Shan Gao, Yongzhong Wang   +7 more
wiley   +1 more source

The anti-interleukin-6 antibody ALD518-P18 mitigates murine kidney ischemia-reperfusion injury. [PDF]

Sci Rep
Bongoni AK, Biondo M, McRae JL, Salvaris EJ, Fisicaro N, Muntz F, Rowe T, Morelli AB, Cowan PJ.   +8 more
europepmc   +1 more source