Results 61 to 70 of about 9,333,661 (382)

Interleukin-6 as a Therapeutic Target [PDF]

Clinical Cancer Research, 2015
Abstract Human IL6 is a cytokine produced by many cell types that has pleiotropic effects. In agreement, anti-IL6 therapy reduces inflammation, hepatic acute phase proteins, and anemia and has antiangiogenic effects. Blocking IL6 has demonstrated therapeutic efficacy with drug registration in Castleman disease and inflammatory diseases ...
Bernard Klein, Bernard Klein, Michel Jourdan, Zhao-Yang Lu, Jean-François Rossi, Jean-François Rossi   +5 more
openaire   +3 more sources

Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain [PDF]

, 2012
Background: Cytokines such as interleukin 6 (IL-6) have been implicated in dual functions in neuropsychiatric disorders. Little is known about the genetic predisposition to neurodegenerative and neuroproliferative properties of cytokine genes.
A Kitamura, AA Willette, AH Miller, AL Jefferson, AL Marsland, AL Sousa, American Psychiatric Association, Astrid V Rauch, AT Beck, B Balasubramaniam, B Viviani, Bernhard T Baune, BL Pierce, BT Baune, BT Baune, Carsten Konrad, CF Terry, Christina Uhlmann, CS Carlson, Dominik Grotegerd, E Brietzke, E Halperin, E Vermetten, Eva Birosova, F Faul, GM MacQueen, H Tilg, H-U Wittchen, Harald Kugel, I HapMap, I Hickie, I Morales, J Ashburner, J Hannestad, J McAfoose, J Oh, JA Wagner, JE Malberg, JM Gatt, JM Kim, Jochen Bauer, JP Godbout, K Kasai, K Pham, Katharina Domschke, KK Bowen, L Capuron, L Christiansen, L Vallieres, L Vitkovic, LD Ward, M Bonafe, M Murphy, M Pickering, M Yamada, MA Kahn, MA Munoz-Fernandez, MK Kang, ML Monje, MT Heneka, N Ohbayashi, N Pervaiz, N Raz, N Tzourio-Mazoyer, O Davidovich, O Islam, P Angelopoulos, P Oeth, P Videbech, Patricia Ohrmann, RA Gadient, RA Gadient, RM Thomas, S Campbell, S Eickhoff, S Ihara, S Ihara, S Lehrl, S Matsuda, S Toulmond, SA Loddick, SD Forman, Sonja Schöning, T Beblo, T Frodl, T Hama, T Hama, T Hirano, Thomas Suslow, U Dannlowski, Udo Dannlowski, V Tancredi, Volker Arolt, Walter Heindel, Y Akaneya, Y Dowlati, Y Kushima, Y Kushima, YP Peng, YY Wu   +99 more
core   +3 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Criteria for the optimal use of interleukin-6 receptor blockers in patients with COVID-19

Терапевтический архив, 2021
Aim. To determine the criteria for the optimal use of IL-6 receptor blockers in patients with COVID-19 community-acquired pneumonia based on predictors of adverse outcomes. Materials and methods.
Tatyana S. Kruglova, Darya S. Fomina, Nataliya G. Poteshkina, Nadija F. Frolova, Irina P. Beloglazova, Zinaida Yu. Mutovina, Inna V. Samsonova, Elena A. Kovalevskaja, Alena I. Zagrebneva, Sofya A. Serdotetckova, Anton A. Chernov, Maryana A. Lysenko   +11 more
doaj   +1 more source

The effect of carbohydrate ingestion on the Interleukin-6 response to a 90-minute run time trial [PDF]

, 2009
Fatigue is a predictable outcome of prolonged physical activity; yet its biological cause remains uncertain. During exercise, a polypeptide messenger molecule interleukin- 6 (IL-6) is actively produced.
Ansley, Les, Barwood, Martin, Eglin, Clare, Robson-Ansley, Paula   +3 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Recombinant production of human interleukin 6 in Escherichia coli. [PDF]

PLoS ONE, 2013
In this study, we compared basic expression approaches for the efficient expression of bioactive recombinant human interleukin-6 (IL6), as an example for a difficult-to-express protein. We tested these approaches in a laboratory scale in order to pioneer
Henrik Nausch, Jana Huckauf, Roswitha Koslowski, Udo Meyer, Inge Broer, Heike Mikschofsky   +5 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Study on relationship between elderly sarcopenia and inflammatory cytokine IL-6, anti-inflammatory cytokine IL-10

BMC Geriatrics, 2018
Background and objectives The pathophysiological mechanism of sarcopenia in the elderly has not yet been fully understood. Here, we aim to explore the relationship between sarcopenia and the inflammatory cytokine interleukin-6 (IL-6), and the anti ...
Yu-Dong Rong, Ai-Lin Bian, Hui-Ying Hu, Yue Ma, Xin-Zi Zhou   +4 more
doaj   +1 more source