Results 71 to 80 of about 9,905,544 (245)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Systemic Inflammation Rapidly Induces Reversible Atrial Electrical Remodeling: The Role of Interleukin‐6–Mediated Changes in Connexin Expression

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2019
Background Systemic inflammation is a strong predictor of atrial fibrillation. A key role for electrical remodeling is increasingly recognized, and experimental data suggest that inflammatory cytokines can directly affect connexins resulting in gap ...
P. Lazzerini, F. Laghi-Pasini, M. Acampa, U. Srivastava, I. Bertolozzi, Beatrice Giabbani, F. Finizola, Francesca Vanni, Aleksander Dokollari, M. Natale, G. Cevenini, E. Selvi, Nicola Migliacci, M. Maccherini, M. Boutjdir, P. Capecchi   +15 more
semanticscholar   +1 more source

HUBUNGAN INTERLEUKIN - 6 DENGAN KUALITAS TIDUR, DEPRESI DAN KUALITAS HIDUP PADA PASIEN PENYAKIT GINJAL KRONIK USIA LANJUT YANG MENJALANI HEMODIALISIS [PDF]

, 2016
AbstrakHUBUNGAN INTERLEUKIN - 6 DENGAN KUALITAS TIDUR, DEPRESI DAN KUALITAS HIDUP PADA PASIEN PENYAKIT GINJAL KRONIK USIA LANJUT YANG MENJALANI HEMODIALISISLatar BelakangSeiring dengan peningkatan jumlah usia lanjut, prevalensi penyakit kronik ...
Adwin Adnan
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis

Circulation, 2019
Supplemental Digital Content is available in the text. Background: Clonal hematopoiesis of indeterminate potential (CHIP) refers to clonal expansion of hematopoietic stem cells attributable to acquired leukemic mutations in genes such as DNMT3A or TET2 ...
A. Bick, J. Pirruccello, G. Griffin, N. Gupta, S. Gabriel, D. Saleheen, P. Libby, S. Kathiresan, P. Natarajan   +8 more
semanticscholar   +1 more source

Endothelial cell-derived interleukin-6 regulates tumor growth [PDF]

, 2014
Background Endothelial cells play a complex role in the pathobiology of cancer. This role is not limited to the making of blood vessels to allow for influx of oxygen and nutrients required for the high metabolic demands of tumor ...
Campos, Marcia S, Danciu, Theodora E, Moren, Juliana, Neiva, Kathleen G, Nör, Jacques E, Warner, Kristy A, Zhang, Zhaocheng   +6 more
core   +2 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

THE CHANGES IN THE LEVEL OF BETA ENDORPHIN, INTERSLEUKIN-2, INTERLEUKIN-4, INTERLEUKIN-6, IMUNOGLOBULIN AND CORTISOL HORMONE ON THE PRACTICES OF SATRIA NUSANTARA [PDF]

, 2010
The purpose of this research is to reveal the changes of immunity at breathing exercises. This is an experimental research study. This research used “randomized pretest-posttest control group design.
Sudarko, Rumpis Agus
core  

Dietary Polyphenols and Periodontitis—A Mini-Review of Literature [PDF]

, 2018
Periodontitis, which is a chronic infection and disease of the periodontium, is a significant global health burden and is linked to other chronic health conditions such as diabetes and cardiovascular diseases.
Basu, Arpita, Ebersole, Jeffrey L., Masek, Emily   +2 more
core   +2 more sources

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source