Results 51 to 60 of about 698,798 (253)

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

The effect of adolescent treadmill mandatory exercise on symptoms of depression and brain inflammatory responses following maternal separation stress in mature male rats [PDF]

فصلنامه ابن سینا, 2017
Background: Early life stressful events have detrimental effects on brain and behavior associated with development of depression. Also immune-inflammatory responses have been reported to contribute in pathophysiology of depression and many studies have ...
F Zolfaghari, M Peeri, Mir-Jamal Hosseini   +2 more
doaj  

Carvacrol alleviates the proconvulsive effects of lipopolysaccharide (LPS) and reduces the gene expression of proinflammatory cytokines interleukin-1 and tumor necrosis factor-α [PDF]

Avicenna Journal of Phytomedicine
Objective: Carvacrol has anti-inflammatory effects. According to the links between inflammatory processes and seizures, this study was designed to investigate the potential effect of carvacrol in reducing seizure severity and involvement of hippocampal ...
Hesamodin Bagheripoor, Mahdieh Mondanizadeh, Mehdi Sadegh   +2 more
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Association Between IL-27 and IL-6 Serum Levels and IgA Nephropathy Alterations

Kidney and Dialysis
Background: IgA nephropathy (IgAN) is the most common primary glomerulonephritis, characterized by immune dysregulation and progressive renal injury. Among immunoregulatory mediators, interleukin-6 (IL-6) and interleukin-27 (IL-27) have been implicated ...
Julian Ananiev, Elina Aleksandrova, Nedelina Terzieva, Iskui Erkanyan, Eduard Tilkiyan, Milena Nikolova-Vlahova   +5 more
doaj   +1 more source

Hall of Fame among pro-inflammatory cytokines: Interleukin-6 gene and its transcriptional regulation mechanisms

Frontiers in Immunology, 2016
Pro-inflammatory cytokines which are generated by immune system cells and mediate many kinds of immune responses are kinds of endogenous polypeptides. They are the effector of the autoimmune system.
Yang Luo, Song Guo Zheng, MD, PhD
doaj   +1 more source

Interleukin‐6 signaling requires only few IL‐6 molecules: Relation to physiological concentrations of extracellular IL‐6

Immunity, Inflammation and Disease, 2020
Introduction The aim of this study was to give quantitative insight into the number of cytokine molecules needed to activate a target cell and relate this to the physiological consequences of the amounts of cytokines typically detectable in humans.
Morten B. Hansen
doaj   +1 more source

Histopathological Evidence of Neurodegenerative Pathology in Epilepsy: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Epilepsy affects > 50 million people worldwide and is associated with a disproportionate burden of cognitive impairment. Emerging evidence suggests that neurodegenerative proteinopathies, particularly hyperphosphorylated tau (p‐tau) and amyloid‐β (Aβ), may contribute to cognitive dysfunction in people with epilepsy (PWE), even in the absence ...
Syeda Amrah Hashmi, Aleksander Luniewski, Vanessa Smith, Matthew McCord, Jaideep Kapur, Mark Quigg, Catherine Joshua, Ifrah Zawar   +7 more
wiley   +1 more source

Increased expression of interleukin-6 gene in gastritis and gastric cancer [PDF]

Brazilian Journal of Medical and Biological Research
Helicobacter pylori (H. pylori) induces an intense inflammatory response, mediated by proinflammatory cytokines, including interleukin (IL)-6 and its membrane receptor (IL-6R), which activates important signaling pathways in the development of gastric ...
M.P. Santos, J.N. Pereira, R.W. Delabio, M.A.C. Smith, S.L.M. Payão, L.C. Carneiro, M.S. Barbosa, L.T. Rasmussen   +7 more
doaj   +2 more sources