Results 61 to 70 of about 10,290,985 (290)

The effect of exercise on plasma soluble IL-6 receptor concentration: a dichotomous response [PDF]

, 2010
The aim of this article is to review current literature on the response of soluble interleukin-6 receptor to exercise and identify a potential role for sIL-6R in skeletal muscle function.
Stevenson, Emma, Nimmo, Myra, Cockburn, Emma, Stevenson, Emma J, Robson-Ansley, Paula, Walshe, Ian, Nimmo, Myra A   +6 more
core  

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF [PDF]

, 2002
Injury to peripheral nerves results in the infiltration of immune cells, which remove axonal- and myelin-derived material. Schwann cells could play a key role in this process by regulating macrophage infiltration.
George K. Tofaris, Kristjan R. Jessen, Rhona Mirsky, Jessen, KR, Patterson, PH, Tofaris, GK, Mirsky, R, Paul H. Patterson   +7 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

An Acute Injection of Porphyromonas Gingivalis Lipopolysaccharide Modulates the Opg/Rankl System and Interleukin-6 in an Ovariectomized Mouse Model

, 2009
Background/aims: In the present study, we attempted to develop a simulated model to explore the causal effects of periodontal pathogens on skeletal homeostasis in postmenopausal osteoporosis.
呂炫;吳銘芳;曾春祺, Lu, H.-K.; Yeh, K.-C.; Wu, M.-F.; Li, C.-L.; Tseng, C.-C.   +1 more
core   +1 more source

Carvacrol alleviates the proconvulsive effects of lipopolysaccharide (LPS) and reduces the gene expression of proinflammatory cytokines interleukin-1 and tumor necrosis factor-α [PDF]

Avicenna Journal of Phytomedicine
Objective: Carvacrol has anti-inflammatory effects. According to the links between inflammatory processes and seizures, this study was designed to investigate the potential effect of carvacrol in reducing seizure severity and involvement of hippocampal ...
Hesamodin Bagheripoor, Mahdieh Mondanizadeh, Mehdi Sadegh   +2 more
doaj   +1 more source

Sexually dimorphic production of interleukin‐6 in respiratory disease

Physiological Reports, 2020
Diverging susceptibility and severity in respiratory diseases is prevalent between males and females. Sex hormones have inconclusively been attributed as the cause of these differences, however, strong evidence exists promoting genetic factors leading to
Karosham D. Reddy, Sandra Rutting, Katrina Tonga, Dikaia Xenaki, Jodie L. Simpson, Vanessa M. McDonald, Marshall Plit, Monique Malouf, Razia Zakarya, Brian G. Oliver   +9 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Heterogeneity of viral IL-6 expression in HHV-8-associated diseases. [PDF]

, 2007
In order to characterize the expression of the viral interleukin-6 (vIL-6) homologue in various human herpesvirus 8 (HHV-8)-associated diseases, in situ hybridization and immunohistochemistry were applied to formalin-fixed specimens.
Cesarman, Ethel, Nicholas, John, Cannon, Jennifer S., Murray, Paul G., Ambinder, Richard F., Orenstein, Jan M., Mann, Risa B., DiGiuseppe, Joseph A., Hayward, Gary S., Browning, Philip J.   +9 more
core   +1 more source

Hall of Fame among pro-inflammatory cytokines: Interleukin-6 gene and its transcriptional regulation mechanisms

Frontiers in Immunology, 2016
Pro-inflammatory cytokines which are generated by immune system cells and mediate many kinds of immune responses are kinds of endogenous polypeptides. They are the effector of the autoimmune system.
Yang Luo, Song Guo Zheng, MD, PhD
doaj   +1 more source