Results 11 to 20 of about 382,334 (303)

Anti–Interleukin-6 and Janus Kinase Inhibitors for Severe Neurologic Toxicity of Checkpoint Inhibitors [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2021
To describe the marked clinical and biological responses of a targeted treatment with anti-interleukin-6 (IL-6)-receptor antibody and Janus kinase (JAK) inhibitors in a patient with a severe, corticoresistant CNS toxicity of immune-checkpoint inhibitor (ICI) therapy.A 58-year-old man was admitted for subacute paraparesis, urinary retention, and ...
Picca, Alberto, Valyraki, Nefeli, Birzu, Cristina, Kramkimel, Nora, Hermine, Olivier, Zahr, Noel, Berzero, Giulia, Psimaras, Dimitri   +7 more
openaire   +3 more sources

Repurposing Interleukin-6 Inhibitors to Combat COVID-19 [PDF]

Journal of Immunotherapy and Precision Oncology, 2020
ABSTRACT Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is a pandemic with major implications across the world. One of the most frequent causes of death from SARS-CoV-2 is fatal pneumonia from coronavirus disease 2019 (COVID-19), which is associated with the development of acute respiratory distress syndrome (ARDS).
Kato, Shumei, Kurzrock, Razelle
openaire   +5 more sources

Phosphorylation at Ser 727 Increases STAT3 Interaction with PKCε Regulating Neuron–Glia Crosstalk via IL-6-Mediated Hyperalgesia In Vivo and In Vitro

Mediators of Inflammation, 2022
Background and Aim. Interleukin-6 (IL-6) modulates neurons–glia crosstalk and subsequently triggers hyperalgesia. This study is aimed at investigating whether the interaction between protein kinase C epsilon (PKCε) and signal transducer and activator of ...
Xiongjuan Li, Biqiang Zhou, Han Yang, Xinping Yang, Zhao Zhao, Zhenglong Pan, Xinran Liao, Wenling Jian, Yuqiang Liu, Han Lu, Qingsheng Xue, Yan Luo, Buwei Yu, Huansen Huang, Daqing Ma, Zhiheng Liu   +15 more
doaj   +1 more source

Role of Interleukin 6 Inhibitors in the Management of Rheumatoid Arthritis

JCR: Journal of Clinical Rheumatology, 2021
Abstract Rheumatoid arthritis (RA) is a multisystem disease that affects the joints and various organs, resulting in compromised quality of life and increased mortality. A wide spectrum of treatment options is available for RA. Conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) are the first-line of treatment for RA ...
Yip, Ronald Man Lung, Yim, Cheuk Wan
openaire   +3 more sources

Effect of ulinastatin on cytokine reaction during gastrectomy [PDF]

Korean Journal of Anesthesiology, 2010
BackgroundInflammation plays an important role in the postoperative morbidity of organs, which is related to the activation of pro-inflammatory and anti-inflammatory cytokines.
Ji Hun Park, Sang Hyun Kwak, Cheol Won Jeong, Hong Beom Bae, Seok Jai Kim   +4 more
doaj   +1 more source

The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling [PDF]

Biochemical Journal, 2004
The immediate early response of cells treated with IL-6 (interleukin-6) is the activation of the signal transducer and activator of transcription (STAT)3. The Src homology domain 2 (SH2)-containing protein tyrosine phosphatase SHP2 and the feedback inhibitor SOCS3 (suppressor of cytokine signalling) are potent inhibitors of IL-6 signal transduction ...
Fischer, Patrick, Lehmann, Ute, Sobota, Radoslaw M., Schmitz, Jochen, NIEMAND, Claudia, Linnemann, Sonja, Haan, Serge, Behrmann, Iris, Yoshimura, Akihiko, Johnston, James A., Müller-Newen, Gerhard, Heinrich, Peter, Schaper, Fred   +12 more
openaire   +4 more sources

Potential biochemical markers of chronic bronchitis

Бюллетень сибирской медицины, 2021
The review systematizes modern data on the biochemical markers that can clarify the nature and the course of chronic bronchitis. The article describes markers associated with bronchopulmonary pathology, such as tumor necrosis factor alpha (TNFα ...
E. A. Kurtukov, Yu. I. Ragino
doaj   +1 more source

Interleukin-6 inhibitors in the treatment of rheumatoid arthritis

Therapeutics and Clinical Risk Management, 2008
Recent developments in understanding the immunopathogenesis of rheumatoid arthritis (RA), combined with progress in biopharmaceutical development, have facilitated the introduction of novel immune modulating therapies for this progressive debilitating disorder.
Stephanie Hennigan, Arthur Kavanaugh
openaire   +6 more sources

Newly diagnosed seropositive rheumatoid arthritis in a 52-year-old man superimposed on long-standing ankylosing spondylitis during secukinumab treatment

Central European Journal of Immunology, 2023
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are severe chronic inflammatory joint diseases with different immune-mediated mechanisms playing a role in their pathogenesis. Rheumatoid arthritis is an erosive arthritis of peripheral joints and
Jaroslaw Nowakowski, Anna Tomoń, Dorota Telesińska-Jasiówka, Mariusz Korkosz   +3 more
doaj   +1 more source

Possibility of complex medicamental and endovascular treatment of pulmonary hypertension in Takayasu arteritis with predominant pulmonary arteries’ lesion [PDF]

Терапевтический архив, 2020
Takayasu arteritis (TA) is a systemic vasculitis with predominatly lesions of aorta and its large branches. In some cases pulmonary arteries (PA) are involved in the pathological inflammatory process and lead to the formation of pulmonary hypertension ...
T. V. Маrtynuk, A. M. Aleevskaya, V. V. Gramovich, N. M. Danilov, I. Z. Korobkova, U. G. Matchin, L. V. Solodovnikova, T. V. Beketova   +7 more
doaj   +1 more source