Results 41 to 50 of about 382,334 (303)

Cerebrospinal Fluid Interleukin-6 in Immune Checkpoint Inhibitor-Induced Autoimmune Meningoencephalitis

The Tohoku Journal of Experimental Medicine, 2022
Immune checkpoint inhibitors (ICIs) have proven clinical benefits in various advanced cancers. However, despite their significant therapeutic efficacy, ICIs induce immune-related adverse events. Among these events, autoimmune meningoencephalitis often has severe effects on patients' outcomes, but its specific clinical features are still unclear.
Mizukami, Takeshi, Masuda, Teruaki, Kimura, Noriyuki, Uchida, Hirotatsu, Jikumaru, Mika, Hanaoka, Takuya, Matsubara, Etsuro   +6 more
openaire   +2 more sources

The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation

Mediators of Inflammation, 1998
Lipopolysaccharide is an inflammatory agent and interleukin-1 is a cytokine. Their pro-inflammatory effects may be mediated by prostanoids produced by inducible cyclooxygenase-2.
W. E. Longo, L. J. Damore, J. E. Mazuski, G. S. Smith, N. Panesar, D. L. Kaminski   +5 more
doaj   +1 more source

Heterotrimeric G Protein Gα13-Induced Induction of Cytokine mRNAs Through Two Distinct Pathways in Cardiac Fibroblasts

Journal of Pharmacological Sciences, 2006
.: Overexpression of constitutively active (CA)-Gα13 significantly increased the expression of interleukin (IL)-1β and IL-6 mRNAs and proteins in rat cardiac fibroblasts.
Nagamatsu Yuichi, Nishida Motohiro, Onohara Naoya, Fukutomi Masashi, Maruyama Yoshiko, Kobayashi Hiroyuki, Sato Yoji, Kurose Hitoshi   +7 more
doaj   +1 more source

Nuclear Factor-κB-Independent Anti-Inflammatory Action of Salicylate in Human Endothelial Cells [PDF]

, 2006
In contrast to aspirin, salicylate, its active metabolite, possesses profound anti-inflammatory properties without blocking cyclooxygenase. Inhibition of the transcription factor nuclear factor-κB (NF-κB) has been discussed to play a role in the anti ...
Blumenthal, Signe B., Vollmar, Angelika M., Kiemer, Alexandra K., Zahler, Stefan, Fürst, Robert   +4 more
core   +1 more source

Identification of small molecules as potential inhibitors of interleukin 6: a multi-computational investigation

Molecular Diversity, 2022
IL(interleukin)-6 is a multifunctional cytokine crucial for immunological, hematopoiesis, inflammation, and bone metabolism. Strikingly, IL-6 has been shown to significantly contribute to the initiation of cytokine storm-an acute systemic inflammatory syndrome in Covid-19 patients.
Que-Huong Tran, Quoc-Thai Nguyen, Thi-Thuy Nga Tran, Thanh-Dao Tran, Minh-Tri Le, Dieu-Thuong Thi Trinh, Van-Thanh Tran, Viet-Hung Tran, Khac-Minh Thai   +8 more
openaire   +2 more sources

Efficacy and safety of levilimab in the treatment of rheumatoid arthritis in real-life clinical practice: first results of the HELIOS observational study

Современная ревматология
The efficacy and safety of levilimab (LVL) in patients with active rheumatoid arthritis (RA) has been confirmed in controlled clinical trials. This article presents the results of a preliminary analysis of a non-interventional observational study of LVL ...
A. M. Lila, I. Z. Gaydukova, O. N. Anoshenkova, I. G. Bannikova, I. B. Vinogradova, M. L. Goldman, S. Yu. Davidian, L. P. Evstigneeva, O. E. Epifanova, E. V. Zemerova, A. I. Zagrebneva, L. V. Ivanova, A. K. Karibova, I. V. Menshikova, O. N. Mironenko, M. P. Mikhailova, N. E. Nikulenkova, I. M. Patrikeeva, T. V. Plaksina, G. R. Savvina, R. R. Samigullina, L. E. Sarantseva, J. V. Usacheva, O. P. Ukhanova, G. F. Fatkhullina, A. L. Chudinov, I. A. Shafieva, S. P. Yakupova   +27 more
doaj   +1 more source

High efficacy and retention rate of levilimab in the treatment of patients with rheumatoid arthritis in real-life practice

Научно-практическая ревматология
Previously published results of a retrospective analysis showed that switching to levilimab from other interleukin 6 receptor inhibitor (iIL6R) allows maintaining the achieved effect, and in some cases, increasing the effectiveness of treatment.
A. I. Zagrebneva, E. N. Simonova, Yu. A. Gavrikova, V. V. Dolgov, G. A. Togizbayev   +4 more
doaj   +1 more source

Expression levels of the JAK/STAT pathway in the transition from hormone-sensitive to hormone-refractory prostate cancer [PDF]

, 2007
The main cause of prostate cancer-related mortality is the development of hormone-refractory disease. Circulating serum levels of IL-6 are raised in hormone-refractory prostate cancer patients and evidence from cell line studies suggests that the IL-6R ...
Tam, L., Traynor, P., P Traynor, McGlynn, L.M., L Tam, Mukherjee, R., J M S Bartlett, J Edwards, Bartlett, J.M.S., Edwards, J., L M McGlynn, R Mukherjee   +11 more
core   +1 more source

Experience of using the interleukin-6 inhibitor olokizumab in patients with rheumatoid arthritis in real-life clinical practice (based on data from Tyumen Regional Rheumatology Center)

Современная ревматология
The Tyumen Regional Rheumatology Center has gained experience in the use of the interleukin-6 inhibitor olokizumab (OKZ) in the treatment of patients with rheumatoid arthritis (RA).Objective: to evaluate the efficacy and safety of OKZ therapy in patients
I. M. Patrikeeva, Yu. A. Lushpaeva, N. V. Knaub, E. A. Ustinova, O. A. Belikov, M. B. Dolgikh, T. Yu. Malysheva   +6 more
doaj   +1 more source

Effect of Medicine on Interleukin-6 Inhibitors and their Forms Against COVID-19

Biointerface Research in Applied Chemistry, 2021
Coronavirus disease-2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), previously known as the 2019 novel coronavirus (2019-nCoV). The first cases were seen in December 2019 in Wuhan. To date, there is no specific treatment for COVID-19 disease.
AKGÖL, SİNAN, KUŞAT, KEVSER
openaire   +3 more sources