Results 231 to 240 of about 1,282,878 (301)
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Current Medicinal Chemistry, 2018
Interleukin 6 (IL-6), a well-known pro-inflammatory cytokine with pleiotropic activity is a central player in chronic inflammatory diseases including cancers. Therefore, blockade of the IL-6 signalling pathway has become a target for the therapy of diverse cancers such as multicentric Castleman’s disease (CD), multiple myeloma and solid tumours ...
Nirmala Chandralega, Kampan +5 more
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Interleukin 6 (IL-6), a well-known pro-inflammatory cytokine with pleiotropic activity is a central player in chronic inflammatory diseases including cancers. Therefore, blockade of the IL-6 signalling pathway has become a target for the therapy of diverse cancers such as multicentric Castleman’s disease (CD), multiple myeloma and solid tumours ...
Nirmala Chandralega, Kampan +5 more
openaire +3 more sources
Journal of Endocrinological Investigation, 2014
To study the characteristics of interleukin 6 (IL6), soluble form of interleukin 6 receptor (sILR)/IL6 complex in obese children and adolescents and its relationship with insulin resistance (IR).66 obese children and adolescents [34 boys, mean age 10.3 ± 2.9 years, z-score of body mass index (BMI) 4.76 ± 1.36] and 24 non-obese healthy sex- and age ...
De Filippo, G. +4 more
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To study the characteristics of interleukin 6 (IL6), soluble form of interleukin 6 receptor (sILR)/IL6 complex in obese children and adolescents and its relationship with insulin resistance (IR).66 obese children and adolescents [34 boys, mean age 10.3 ± 2.9 years, z-score of body mass index (BMI) 4.76 ± 1.36] and 24 non-obese healthy sex- and age ...
De Filippo, G. +4 more
openaire +5 more sources
Interleukin-6 and interleukin-6 receptor gene expression in pituitary tumors
Journal of Neuro-Oncology, 1994Interleukin-6 (IL-6) is a multifunctional cytokine which plays a role in the stimulation, inhibition, differentiation, and regulation of cell growth. IL-6 has been shown to act as an autocrine growth factor in several tumors, and is expressed by a variety of tumors. IL-6 also exhibits a regulatory role in the hypothalamo-pituitary axis.
A R, Rezai +4 more
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Serum interleukin-6 and interleukin-6 soluble receptor in Alzheimer's disease
Neuroscience Letters, 1998Serum levels of interleukin-6 (IL-6) and interleukin-6 soluble receptor (IL-6sR) were measured in 41 patients (23 female and 18 male, mean age 72.5 years) with Alzheimer's disease (AD) and in 32 controls (14 women and 18 men, mean age 69.2 years) using enzyme-linked immunosorbent assays (ELISA).
P, Angelis +4 more
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Serum Interleukin-6, Soluble Interleukin-6 Receptor and Crohn’s Disease Activity
Digestive Diseases and Sciences, 2007The relationship between plasma interleukin-6 (IL-6) concentration and its soluble receptor in Crohn's disease (CD) is not well elucidated. Twenty healthy volunteers and 94 consecutive patients with CD (44 in relapse and 50 in remission) were studied. Plasma IL-6 concentrations in patients with active disease [80 +/- 9 pg/ml; mean +/- standard error of
Stéphane, Nancey +5 more
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Pediatric Neurology, 2019
BACKGROUND Outcome in severe acute necrotizing encephalopathy of childhood is poor, with high mortality (30%) and moderate to severe disability in survivors despite the use of intravenous corticosteroids or immunoglobulins.
J. Koh +3 more
semanticscholar +1 more source
BACKGROUND Outcome in severe acute necrotizing encephalopathy of childhood is poor, with high mortality (30%) and moderate to severe disability in survivors despite the use of intravenous corticosteroids or immunoglobulins.
J. Koh +3 more
semanticscholar +1 more source
Anti-Interleukin-6 and Soluble Interleukin-6 Receptor in Systemic Lupus Erythematosus
Lupus, 1994IL-6, soluble IL-6 receptor and IgG with anti-IL-6 activity were measured in the plasma of 14 lupus patients and 10 normal subjects. The capacity of peripheral blood mononuclear cells to spontaneously produce IL-6 in vitro was also measured. Our results indicate that IL-6 plasma levels in patient plasma as measured by ELISA were not different from ...
M, Evans, N I, Abdou
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Hodgkin and Reed-Sternberg Cells Express Interleukin 6 and Interleukin 6 Receptors
Leukemia & Lymphoma, 1992Interleukin 6 (IL-6) is a pleiotropic lymphokine which can stimulate a variety of cells including B and T lymphocytes. It has been suggested that IL-6 plays a crucial role in several diseases such as human plasmacytoma, cardiac myxoma or Castleman's Disease by autocrine or paracrine stimulation.
H, Tesch +6 more
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Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration
Gastroenterology, 2000Liver regeneration after loss of hepatic tissue leads to hepatocyte and nonparenchymal cell proliferation and rapid restoration of liver parenchyma. Interleukin (IL)-6 is a key inducer of transcription factors involved in liver regeneration. Whenever IL-6 activates target cells, it binds to a specific IL-6 receptor (IL-6R).
M, Peters +6 more
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