Results 241 to 250 of about 76,985,047 (293)
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Interleukin-7 in rheumatoid arthritis
Rheumatology, 2008Recent data from several groups demonstrate high levels of IL-7 in the joints of RA patients, but much lower levels in OA. In contrast, circulating levels of IL-7 in RA remain a point of debate. IL-7 has many roles in T cell, dendritic cell and bone biology in humans.
S M, Churchman, F, Ponchel
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Interleukin-7: from bench to clinic
Blood, 2002Interleukin-7 (IL-7) was initially isolated more than 10 years ago.[1-4][1] Nevertheless, the complete set of physiologic roles for this cytokine, especially those involving lymphocyte homeostasis, have only recently been elucidated. After the initial descriptions of effects on B-cell precursors,
Terry J, Fry, Crystal L, Mackall
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Deficit of interleukin 7 in septic patients
International Immunopharmacology, 2014We recently demonstrated an overall decrease of all αβ and specially γδ T cell subsets in patients with sepsis compared with healthy subjects. IL-7 is a crucial factor for development of γδ T cells and survival in sepsis but its association with sepsis severity, evolution of organ failure and death still has not been investigated. Sera from 78 patients
Andreu-Ballester JC +9 more
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1995
Abstract The human IL-7 receptor is produced as a 459-amino-acid precursor with a predicted 20-amino-acid signal peptide (GenBank accession number M29696) (Fig. 1). It contains a single transmembrane domain of 25 amino acids, an extracellular domain of 219 amino acids, and a cytoplasmic domain of 195 amino acids.
R G Goodwin, L S Park
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Abstract The human IL-7 receptor is produced as a 459-amino-acid precursor with a predicted 20-amino-acid signal peptide (GenBank accession number M29696) (Fig. 1). It contains a single transmembrane domain of 25 amino acids, an extracellular domain of 219 amino acids, and a cytoplasmic domain of 195 amino acids.
R G Goodwin, L S Park
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Interleukin-7 and Type 1 Diabetes
Current Diabetes Reports, 2014Antigen-experienced T-cells directly target and destroy insulin-producing beta cells in patients with Type 1 diabetes. Consequently, T-cells are also major targets of immunomodulatory strategies that aim to prevent or delay the immune mediated loss of islet beta-cell function.
Paolo, Monti, Ezio, Bonifacio
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Interleukin 7, maestro of the immune system
Seminars in Immunology, 2012X ; 1 ; 1 ; 8 ; scie ...
Sprent, J, Surh, CD
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Interleukin-7 activates intestinal lymphocytes
Digestive Diseases and Sciences, 1995Human intestinal lymphocytes, particularly intraepithelial lymphocytes, proliferate minimally to some agents, like mitogens and stimuli of the CD3 pathway. This in vitro finding may be due, in part, to a loss of factors found in vivo. Three T-cell growth factors, IL-7, IL-9, and IL-12, were tested for their ability to stimulate the proliferation of ...
M, Bilenker +3 more
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European Journal of Immunology, 1994
AbstractThe recently characterized receptor for interleukin (IL)‐7 (IL‐7R) includes a unique α chain as well as a common γ chain shared with the receptors for IL‐2 and IL‐4. Engagement of the IL‐7R activates the intracellular enzyme phosphatidylinositol (PtdIns) 3‐kinase but the mechanism of PtdIns 3‐kinase activation and the molecular basis of its ...
A R, Venkitaraman, R J, Cowling
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AbstractThe recently characterized receptor for interleukin (IL)‐7 (IL‐7R) includes a unique α chain as well as a common γ chain shared with the receptors for IL‐2 and IL‐4. Engagement of the IL‐7R activates the intracellular enzyme phosphatidylinositol (PtdIns) 3‐kinase but the mechanism of PtdIns 3‐kinase activation and the molecular basis of its ...
A R, Venkitaraman, R J, Cowling
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Interleukin-7: Fuel for the autoimmune attack
Journal of Autoimmunity, 2013Interleukin-7 (IL-7) is a critical survival factor for lymphocytes and recent studies suggest targeting the IL-7/IL-7Rα pathway holds promise for the treatment of autoimmune diseases. Several lines of evidence, genetic as well as functional, indicate an important role for this cytokine in autoimmune inflammation: polymorphisms in the IL-7Rα have been ...
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