Results 61 to 70 of about 76,985,047 (293)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Cellular and matrix interactions during the development of T lymphocytes

Brazilian Journal of Medical and Biological Research, 1999
The thymus contains an extensive extracellular matrix. Although thymocytes express integrins capable of binding to matrix molecules, the functional significance of the matrix for T cell development is uncertain.
J.J.T. Owen, D.E. McLoughlin, R.K. Suniara, E.J. Jenkinson   +3 more
doaj   +1 more source

Interleukin‐7. Biology and implications for dermatology [PDF]

Experimental Dermatology, 1996
Abstract In recent years, it has become apparent that IL‐7, originally characterized as a growth factor for pre‐B lymphocytes. also has important implications for the skin. Keratinocytes have been shown to produce IL‐7, which in turn can elicit a variety of biological responses on several cell types residing in the skin.
P, Möller, M, Böhm, B M, Czarnetszki, D, Schadendorf   +3 more
openaire   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Relationship Between Acinetobacter baumannii Pneumonia and Human CTLA4 Gene Polymorphism (rs231775) in Relation to IL-7 Serum Levels: A Study on Host–Pathogen Dynamics

Frontiers in Bioscience-Scholar
Background: The relationship between genetic variations and susceptibility to infection provides insight into the pathogenesis of diseases caused by infections, illustrating host–pathogen interactions, informing preventive measures ...
Mayadah Mohammed Ridha Abdul-Razzaq, Wasan Abdul-Elah Bakir, Zainab Fadhel Ashoor, Refif Sabih Al-Shawk   +3 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy treated with interleukin-7

Clinical Infection in Practice, 2020
Background: Progressive multifocal leukoencephalopathy (PML) is a rare devastating brain infection caused by the JC polyomavirus (JCPyV) in patients with impaired cellular immune responses. In the absence of effective anti-viral therapy, it is unclear if
Karl B. Alstadhaug, Christine Hanssen Rinaldo, Liv Osnes, Irini Sereti, Hilde K. Ofte   +4 more
doaj   +1 more source

Expression of biologically active bovine interleukin 7 and evaluating the activity in vitro [PDF]

Veterinary World, 2016
Aim: Interleukin 7 (IL-7) is a ϒc family cytokine involved in the homeostatic proliferation and maintenance of immune cells. In the present study, we report the expression of bovine IL-7 (bIL-7) in Escherichia coli and evaluated for its biological ...
J. Lijo , N. Vijay , H. J. Dechamma, G. R. Reddy   +3 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study [PDF]

, 2012
Background: Interleukin-22 (IL-22), recently identified as a crucial parameter of pathology in experimental liver damage, may determine survival in clinical end-stage liver disease.
Stefan Zeuzem, Herrmann, Eva, Oliver Waidmann, Kronenberger, Bernd, Friederike Brunner, Rudloff, Ina, Bernd Kronenberger, Waidmann, Oliver, Albrecht Piiper, Pfeilschifter, Josef (Prof. Dr.), Piiper, Albrecht, Heiko Mühl, Filmann, Natalie, Ina Rudloff, Malte Bachmann, Eva Herrmann, Josef Pfeilschifter, Lisa Kapper, Bachmann, Malte, Brunner, Friederike, Kapper, Lisa, Mühl, Heiko, Natalie Filmann, Zeuzem, Stefan, Kronenberger Bernd, Brunner Friederike, Filmann Natalie, Kapper Lisa, Herrmann Eva, Zeuzem Stefan, Mühl Heiko, Rudloff Ina, Piiper Albrecht, Waidmann Oliver, Bachmann Malte, Pfeilschifter Josef   +35 more
core   +2 more sources