Results 51 to 60 of about 1,297,479 (340)
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Frontiers in Molecular BiosciencesThe heterocycle compounds, with their diverse functionalities, are particularly effective in inhibiting Janus kinases (JAKs). Therefore, it is crucial to identify the correlation between their complex structures and biological activities for the ...
Abdelmoujoud Faris +7 more
doaj +1 more source
Journal of Venomous Animals and Toxins including Tropical Diseases, 2015 Background The yellow scorpion Tityus serrulatus (Ts) is responsible for the highest number of accidents and the most severe scorpion envenoming in Brazil. Although its venom has been studied since the 1950s, it presents a number of orphan peptides that
Priscila C. Lima +6 more
doaj +1 more source
Age-dependent immune responses in COVID-19-mediated liver injury: focus on cytokines
Frontiers in Endocrinology, 2023 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is potentially pathogenic and causes severe symptoms; in addition to respiratory syndromes, patients might experience other severe conditions such as digestive complications and liver ...
Nazanin Aghamohamadi +7 more
doaj +1 more source
Interleukin‐1α, interleukin‐2, and soluble interleukin‐2 receptors in polymyositis [PDF]
Arthritis & Rheumatism, 1990 AbstractCell‐mediated immunity has been implicated in the pathogenesis of polymyositis (PM). We conducted a prospective study in which serum levels of soluble interleukin‐2 receptors (IL‐2R), IL‐1α, and IL‐2 were correlated with creatine kinase (CK) levels and clinical disease activity.
Bruce A. Baethge, Robert E. Wolf
openaire +3 more sources
Novel immune mechanisms in hypertension and cardiovascular risk [PDF]
, 2017 Purpose of Review: Hypertension is a common disorder with substantial impact on public health due to highly elevated cardiovascular risk. The mechanisms still remain unclear and treatments are not sufficient to reduce risk in majority of patients ...
Guzik, Tomasz J. +3 more
core +2 more sources
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Assessment of IL-8 levels in saliva of healthy and chronic periodontitis individuals
Journal of Pharmacy and Bioallied SciencesInflammation of the gums and other tissues supporting the teeth, as well as gradual loss of attachment and bone, are the results of chronic periodontitis, an infectious illness.
Vinaykumar G Suryavanshi +5 more
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The IL-17 Family of Cytokines in Psoriasis: IL-17A and Beyond
Frontiers in Immunology, 2018 Psoriasis is a frequent chronic inflammatory skin disease, nowadays considered a major global health problem. Several new drugs, targeting the IL-23/IL-17A pathway, have been recently licensed or are in clinical development.
Nicolo Costantino Brembilla +3 more
doaj +1 more source