Results 201 to 210 of about 1,132,369 (355)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Targeting interleukin-1 signaling for renoprotection. [PDF]

Front Immunol
Bogdanova D, Samsonov MY, Lebedeva S, Bukhanova D, Materenchuk M, Mutig K.   +5 more
europepmc   +1 more source

NICOTINAMIDE AND INTERLEUKIN-1 (IL-1) EFFECTS ON HUMAN PANCREATIC ISLET FUNCTION [PDF]

, 1993
Urs Zumsteg, Mathias D. Brendel, Rodolfo Alejandro, Jørn Nerup   +3 more
openalex   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Evaluation of salivary interleukin 6 interleukin 1 beta and interferon gamma in oral and mucocutaneous lichen planus patients. [PDF]

Sci Rep
Hama PN, Ahmed KM.
europepmc   +1 more source

Analysis of interleukin 1 mediated radioprotection.

, 1986
I Manori, A Kushilevsky, Yacob Weinstein
openalex   +1 more source

Interleukin-1 Receptor Antagonist (IL-1RN) Gene Variable Number Tandem Repeats (VNTR) Polymorphism Association in men Infertility in Erbil City /Kurdistan Iraq

, 2021
Yassin Kareem Amin, Ashti Mohammad Amin Said, Ahmed A. Al-Naqshbandi, Saeed Ghulam   +3 more
openalex   +2 more sources

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Cleaved SREBP-2 C-terminal fragment noncanonically drives interleukin-1 receptor-associated kinase 1-dependent apoptosis. [PDF]

Signal Transduct Target Ther
Yeon M, Kim WK, Shin HB, Lee YB, Rhee HW, Seo YK.   +5 more
europepmc   +1 more source

Asthma and coagulation [PDF]

, 2013
Hammad, Hamida, Lambrecht, Bart
core   +1 more source