Results 71 to 80 of about 1,132,369 (355)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Investigation of interleukin-1 alpha and interleukin-6 expression and interleukin-1 alpha gene polymorphism in keratocystic odontogenic tumors and ameloblastomas [PDF]

, 2011
Objective: In jawbones, ameloblastomas and odontogenic keratocysts share many clinical features in common such as aggressiveness, high recurrence rates and radical management options.
Oygür, Tüllin, Sengüven, Burcu
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Expression of Interleukin-1 and Temporomandibular Disorder: Contemporary Review of the Literature [PDF]

, 2017
Objective: Temporomandibular disorders (TMD) are a group of conditions affecting the temporomandibular joint (TMJ), leading to jaw dysfunction, joint and muscle pain, and a decrease in quality of life.
Almeida, Luis Eduardo, Bosio, Jose A., Butcher, Seth, Hresko, Kyle, Leonardi, Rosalia, Loreto, Carla, Pierce, Sean, Sorenson, Adam, Tramontina, Vinícius Augusto   +8 more
core   +1 more source

Genome engineering of stem cells for autonomously regulated, closed-loop delivery of biologic drugs [PDF]

, 2017
Chronic inflammatory diseases such as arthritis are characterized by dysregulated responses to pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor α (TNF-α).
Brunger, Jonathan M, Gersbach, Charles A, Guilak, Farshid, Willard, Vincent P, Zutshi, Ananya   +4 more
core   +3 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

In Silico Bahan Aktif Epigallocatechin Gallate dari Sargassum cristaefolium untuk Menghambat Pembentukan Interleukin 1B pada Sindroma Mata Kering

Spizaetus
Sindroma mata kering adalah kondisi multifaktorial yang mengganggu air mata dan permukaan mata, menyebabkan ketidaknyamanan, gangguan penglihatan, dan kerusakan permukaan mata. Sargassum cristaefolium, alga coklat yang ditemukan di Indonesia, mengandung
Muhammad Nabil Faiq, Irma A. Pasaribu, Tamam Jauhar, Verna Biutifasari   +3 more
doaj   +1 more source

Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors

Journal of Neuroinflammation, 2011
Background We have previously outlined functional interactions, including feedback cycles, between several of the gene products implicated in the pathogenesis of Alzheimer's disease.
Liu Ling, Aboud Orwa, Jones Richard A, Mrak Robert E, Griffin W Sue T, Barger Steven W   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Autoinflammatory diseases. Part 3: NLRP and NLRC inflammasomopathies. Biologic therapies for inflammasomopathies

Zdorovʹe Rebenka
Inflammasomopathies and other enhanced interleukin (IL)-1 signaling syndromes represent a significant cluster of systemic autoinflammatory diseases (SAIDs) which are monogenic disorders characterized by episodic spontaneous multisystemic inflammation ...
O.V. Shvaratska, T.A. Bordii, M.V. Kalichevska, O.V. Klymenko, O.M. Taran, O.V. Klimova, Ya.V. Vilenskyi, T.K. Mavropulo   +7 more
doaj   +1 more source