Results 21 to 30 of about 652,597 (257)

Investigation of Interleukin-10 Promoter Polymorphisms and Interleukin-10 Levels in Children with Irritable Bowel Syndrome

Gut and Liver, 2013
Background/AimsThe aim of this study was to investigate whether genetic variations at positions -1082, -819, and -592 in the interleukin (IL)-10 promoter affect IL-10 production in children with irritable bowel syndrome (IBS).Methods : Ninety-four ...
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Factors Associated With In Vitro Interferon-gamma Production in Tuberculosis

Journal of the Formosan Medical Association, 2011
Macrophage activation assisted by interferon-gamma (IFN-γ) is a primary mechanism by which Mycobacterium tuberculosis is killed, but IFN-γ (production is inhibited in tuberculosis (TB) patients. The production of IFN-γ is influenced by many factors, such
Chung-Chieh Yu, Yu-Chih Liu, Chien-Ming Chu, Duen-Yau Chuang, Wen-Chen Wu, Huang-Pin Wu   +5 more
doaj   +1 more source

IL-10/β-Endorphin-Mediated Neuroimmune Modulation on Microglia during Antinociception

Brain Sciences, 2023
Microglia are glial cells centrally related to pathophysiology and neuroimmunological regulation of pain through microglia–neuron crosstalk mechanisms. In contrast, anti-inflammatory mechanisms guided by immunological effectors such as IL-10 trigger the ...
Thiago Caetano Andrade Belo, Gabriela Xavier Santos, Bruno Eduardo Gabriel da Silva, Bruno Lopes Gonçalves Rocha, Dennis William Abdala, Larissa Alves Moreira Freire, Fernanda Santos Rocha, Giovane Galdino   +7 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Serum IL-6 and IL-10 levels are associated with fatal outcomes in patients with SFTS in China

Journal of Infection in Developing Countries
Introduction: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with a high mortality rate and is a public health concern.
Xiaoyi Liu, Fan Zhang, Jinping Qiao, Wentao He   +3 more
doaj   +1 more source

Cytokine profile in patients with early latent syphilis.

Medičnì Perspektivi, 2018
The purpose of this study was to study the change in the content of the most active cytokines (interleukins 6 and 10) during the formation of the immune response in patients with latent early syphilis, as well as to study the possible relationship ...
S. V. Zakharov
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

THE ASSOCIATION OF PROCALCITONIN, LACTATE, WBC COUNT, AND INTERLEUKIN-10 MAY BE HELPFUL IN THE EARLY DIAGNOSIS OF SEPSIS IN BRAZILIAN PATIENTS

Arquivos de Ciências da Saúde da UNIPAR
Introduction: Sepsis is a set of clinical symptoms resulting from inflammation and infection. Several biomarkers are used for early diagnosis and improved management of sepsis.
Cristiane Alves da Silva Menezes, Victor Hugo Ferreira Gomes, Fernanda Rocha de Freitas, Simone Martins Gonçalves, Pâmela Santos Azevedo, Edna Afonso Reis, Ieda de Fátima Oliveira Silva, Ana Paula Lucas Mota   +7 more
doaj   +1 more source