Results 211 to 220 of about 4,886,092 (271)

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

Spatial proteomics identifies a novel CRTC-dependent viral sensing pathway that stimulates production of Interleukin-11

Ravenhill BJ, Oliveira M, Wood G, Di Y, Davies CT, Lu Y, Antrobus R, Elliott G, Irigoyen N, Hughes DJ, Lyons P, Chung B, Borner GH, Weekes MP.   +13 more
europepmc   +1 more source

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Enhancing Interleukin-6 and Interleukin-11 receptor cleavage

The International Journal of Biochemistry & Cell Biology, 2017
Proteolytic cleavage of the membrane-bound Interleukin-6 receptor (IL-6R) by the metalloprotease ADAM17 releases an agonistic soluble form of the IL-6R (sIL-6R), which is responsible for the pro-inflammatory trans-signaling branch of the cytokine's activities.
Juliane, Lokau, Marieke, Wandel, Christoph, Garbers   +2 more
openaire   +3 more sources

Emerging roles for Interleukin-11 in disease

Growth Factors, 2019
Interleukin (IL)-11 belongs to the IL-6 family of cytokines, discovered over 30 years ago. While early studies focused on the ability of IL-11 to stimulate megakaryocytopoiesis, the importance of this cytokine to inflammatory disease and cancers is only just beginning to be uncovered.
Paul M, Nguyen, Suad M, Abdirahman, Tracy L, Putoczki   +2 more
openaire   +3 more sources

Modular organization of Interleukin-6 and Interleukin-11 α-receptors

Biochimie, 2015
Interleukin (IL)-6 and IL-11 are the only canonical members of the IL-6 family of cytokines that induce signaling through a homodimer of the common β-receptor glycoprotein (gp)130. A pre-requisite for signal transduction is the initial binding of the cytokines to their unique α-receptors, IL-6R and IL-11R.
Rebecca Nitz, Juliane Lokau, Samadhi Aparicio-Siegmund, Jürgen Scheller, Christoph Garbers   +4 more
openaire   +3 more sources

Interleukin-11 drives human and mouse alcohol-related liver disease

Gut, 2022
Objective Alcoholic hepatitis (AH) reflects acute exacerbation of alcoholic liver disease (ALD) and is a growing healthcare burden worldwide. Interleukin-11 (IL-11) is a profibrotic, proinflammatory cytokine with increasingly recognised toxicities in ...
M. Effenberger, A. Widjaja, F. Grabherr, B. Schaefer, C. Grander, L. Mayr, Julian Schwaerzler, Barbara Enrich, P. Moser, Julia Fink, A. Pedrini, N. Jaschke, A. Kirchmair, A. Pfister, B. Hausmann, R. Bale, D. Putzer, H. Zoller, S. Schafer, Petra Pjevac, Z. Trajanoski, G. Oberhuber, T. Adolph, S. Cook, H. Tilg   +24 more
semanticscholar   +1 more source

The cytokine interleukin-11 crucially links bone formation, remodeling and resorption.

Cytokine & growth factor reviews, 2021
Bone development is a complex process that requires the activity of several different signaling pathways and cell types. It involves the coordinated action of osteoclasts (cells that are capable of resorbing bone), osteoblasts (cells that are able to ...
Birte Kespohl, Tim Schumertl, J. Bertrand, J. Lokau, Christoph Garbers   +4 more
semanticscholar   +1 more source

Interleukin-11

Leukemia & Lymphoma, 1994
Interleukin-11 (IL-11), a stromal cell-derived cytokine, has been known to act widely in hematopoietic and non-hematopoietic systems. IL-11 supports the growth of certain types of plasmacytoma and hybridoma cells, acts with interleukin-3 (IL-3) in shortening the Go period of early progenitors.
S, Kobayashi, M, Teramura, K, Oshimi, H, Mizoguchi   +3 more
openaire   +4 more sources

Interleukin-11

Definitions, 2020
openaire   +2 more sources

Interleukin‐11: A gp130 Cytokine

Annals of the New York Academy of Sciences, 1998
ABSTRACT: Interleukin (IL)‐11 is a member of the gp130 family of cytokines. Comparison of IL‐11 with another gp130 family member, IL‐6, indicates that these two cytokines share many overlapping signal transduction mechanisms. However, unlike IL‐6, treatment of patients with a recombinant human form of IL‐11 (rhIL‐11) does not increase body temperature,
William L, Trepicchio, Andrew J, Dorner
openaire   +2 more sources