Results 271 to 280 of about 986,782 (400)

Tumor-specific AAV delivery of interleukin-12 enhances antitumor immunity and safety in ovarian cancer xenograft mouse model. [PDF]

Mol Ther Oncol
Chen C, Jiang Y, Feng C, Zhou Q, Luo X, Cai L, Zhao L.   +6 more
europepmc   +1 more source

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

Proceedings of the National Academy of Sciences of the United States of America, 1993
R. Gazzinelli, S. Hieny, T. Wynn, S. Wolf, A. Sher   +4 more
semanticscholar   +1 more source

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

Monocyte-regulated interleukin 12 production drives clearance of Staphylococcus aureus. [PDF]

PLoS Pathog
Peignier A, Kim J, Lemenze A, Parker D.
europepmc   +1 more source

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

Atomic Pt-Layer-Coated Au Peroxidase Nanozymes with Enhanced Activity for Ultrasensitive Colorimetric Immunoassay of Interleukin-12. [PDF]

Biosensors (Basel)
Zhang H, Peng X, Song H, Tan Y, Xu J, Li Q, Gao Z.   +6 more
europepmc   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

KORELASI PROFIL LIPID DENGAN INTERLEUKIN-12 PADA DIABETES MELITUS TIPE 2 [PDF]

, 2017
Ponda Sari Meri
openalex  

Effect of interleukin 12 (IL-12) on embryonic development and yolk sac vascularisation

, 2014
Mehtap Nisari, Hacer Ülger, Erdoğan Unur, Ömer Karaca, Tolga Ertekın   +4 more
openalex   +2 more sources

Anti-interleukin-12 antibody for active Crohn's disease.

New England Journal of Medicine, 2004
P. Mannon, I. Fuss, L. Mayer, C. Elson, W. Sandborn, D. Present, B. Dolin, Nancy Goodman, C. Groden, R. Hornung, M. Quezado, Zhiqiong Yang, M. Neurath, J. Salfeld, G. Veldman, U. Schwertschlag, W. Strober   +16 more
semanticscholar   +1 more source