Results 281 to 290 of about 986,782 (400)

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Dendritic Cell Derived-Extracellular Vesicles Engineered to Express Interleukin-12 and Anti-CTLA-4 on Their Surface for Combinational Cancer Immunotherapy. [PDF]

J Extracell Vesicles
Chen J, Tan Q, Yang Z, Chen W, Zhou E, Li M, Deng J, Wu Y, Liu J, Xu J, Guo M, Jin Y.   +11 more
europepmc   +1 more source

Balans Cairan, Interferon-Gamma, Interleukin-12 dan Tumor Necrosis Factor Sebagai Faktor Prediksi Kesembuhan pada Sepsis Berat Fluid Balance, Interferon-Gamma, Interleukin- 12 and Tumor Necrosis as predictive factors of Survival in Severe Sepsis

, 2012
Djoko Trihadi Lukmono Subagyo
openalex   +2 more sources

Bile acids induce monocyte differentiation toward interleukin‐12 hypo‐producing dendritic cells via a TGR5‐dependent pathway

Immunology, 2012
Riko Ichikawa, T. Takayama, Kazuaki Yoneno, N. Kamada, M. Kitazume, H. Higuchi, K. Matsuoka, Mitsuhiro Watanabe, H. Itoh, T. Kanai, T. Hisamatsu, T. Hibi   +11 more
semanticscholar   +1 more source

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

Advanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan, Xuelin Wang, Zhongyao Chen, Shuo Wang, Weining Gao, Ziyi Chen, Runyang Li, Cheng Hao, Lei Zhang, Qiongqiong Zhang, Ke Zhang, Mei Yu, Qian Liu, Jingxuan Wang, Huiping Li, Simpkins Fiona, Jing Liu, Qiang Liu, Peng Liu, Yawei Hu   +19 more
wiley   +1 more source

Interleukin-12 encoded by the oncolytic virus VSV-GP enhances therapeutic antitumor efficacy by inducing CD8+ T-cell responses with a long-lived effector cell phenotype. [PDF]

J Immunother Cancer
Hatami J, Das K, Wolf L, Aufschnaiter A, Kimpel J, Nolden T, Schreiber LM, Müllauer B, Podgorschek E, Schwaiger T, Spiesschaert B, Wollmann G, Elbers K, von Laer D, Bánki Z.   +14 more
europepmc   +1 more source

Interleukin-12 Converts Foxp3+ Regulatory T Cells to Interferon–γ-Producing Foxp3+ T Cells That Inhibit Colitis

, 2011
Ting Feng, Anthony Cao, Casey T. Weaver, Charles O. Elson, Yingzi Cong   +4 more
openalex   +2 more sources

A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease.

Gastroenterology, 2008
W. Sandborn, B. Feagan, R. Fedorak, E. Scherl, M. Fleisher, S. Katz, J. Johanns, M. Blank, P. Rutgeerts   +8 more
semanticscholar   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Recombinant Oncolytic Vesicular Stomatitis Virus Expressing Mouse Interleukin-12 and Granulocyte-Macrophage Colony-Stimulating Factor (rVSV-dM51-mIL12-mGMCSF) for Immunotherapy of Lung Carcinoma. [PDF]

Int J Mol Sci
Ryapolova A, Zinovieva M, Vorona K, Krapivin B, Moroz V, Gasanov N, Imatdinov I, Imatdinov A, Ivanov R, Karabelsky A, Minskaia E.   +10 more
europepmc   +1 more source