Results 31 to 40 of about 972,723 (306)

Virus-Like Particle-Mediated Vaccination against Interleukin-13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis [PDF]

, 2020
Virus-like particle (VLP)-based anti-infective prophylactic vaccination has been established in clinical use. Although validated in proof-of-concept clinical trials in humans, no VLP-based therapeutic vaccination against self-proteins to modulate chronic
Foerster, John, Molęda, Aleksandra
core   +2 more sources

Co-stimulation of the fc receptor and interleukin-12 receptor on human natural killer cells leads to increased expression of cd25

OncoImmunology, 2018
Natural killer (NK) cells serve a critical role in the immune response against microbes and developing tumors. We have demonstrated that NK cells produce stimulatory cytokines (e.g., IFN-γ) in response to potent stimulation via immobilized IgG (to engage
Megan C. Duggan, Amanda R. Campbell, Elizabeth L. McMichael, Kallan S. Opheim, Kala M. Levine, Neela Bhave, Michelle C. Culbertson, Tiffany Noel, Lianbo Yu, WE Carson   +9 more
doaj   +1 more source

Regulation of NK cell development and function by cytokines

Frontiers in Immunology, 2013
Natural Killer (NK) cells are innate lymphocytes with an important role in the early defense against intracellular pathogens and against tumors. Like other immune cells, almost every aspects of their biology are regulated by cytokines.
Antoine eMarçais, Sébastien eViel, Morgan eGrau, Thomas eHenry, Jacqueline eMarvel, Thierry eWalzer   +5 more
doaj   +1 more source

CpG and Interleukin-15 Synergize to Enhance IFN-γ Production by Activated CD8+ T Cells [PDF]

, 2012
Interleukin-15 (IL-15) regulates the development and maintenance of memory CD8+ T cells. Paradoxically, we previously reported that IL-15 could enhance CD8+ T-cell responses to IL-12, a proinflammatory cytokine required for optimal priming of effector ...
Cobb, Dustin, Guo, Siqi, Smeltz, Ronald B.   +2 more
core   +5 more sources

Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomas. [PDF]

, 2005
PURPOSE: To evaluate the feasibility and safety of intratumoral injection of autologous dendritic cells (DCs) transfected with an adenovirus encoding interleukin-12 genes (AFIL-12) for patients with metastatic gastrointestinal carcinomas. Secondarily,
Alfaro, C. (Carlos), Arina, A. (Ainhoa), Bendandi, M. (Maurizio), Benito, A. (Alberto), Feijoo, E. (Esperanza), Herraiz-Bayod, M.J. (Maite J.), Herrero, J.I. (José Ignacio), Lucena, F. (Felipe), Mazzolini, G. (Guillermo), Melero, I. (Ignacio), Olagüe, C. (Cristina), Prieto, J. (Jesús), Qian, C. (Cheng), Quiroga, J. (Jorge), Ruiz, J. (Juan), Sadaba, B. (Belén), Sangro, B. (Bruno), Sola, J. (Josu), Subtil, J.C. (José Carlos), Tirapu, I. (Íñigo)   +19 more
core   +1 more source

Correlation between serum levels of interleukins 10 and 12 and thrombocytopenia in hepatitis C cirrhotic (class A) patients

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
Hepatitis C virus (HCV) patients commonly have low platelet counts; however, the exact role of HCV infection in thrombocytopenia is unknown. This work aimed to study the serum levels of interleukins (IL) 10 and 12 in patients with mild and moderate ...
N Abdallah, HK Abdel Aziz, NA Hamed, M Gamal   +3 more
doaj   +1 more source

The Role of Interleukin 12 in Iraqi Patients with Psoriasis

مجلة علوم ذي قار, 2022
Psoriasis is a chronic skin condition with immune-mediated inflammatory etiology. Many studies have indicated that Interleukin-12 (IL-12) plays an essential role in the severity of psoriasis.So to elucidate IL-12 role in regulating psoriasis promotion ...
Emad A. Abbas, Hind M Mousa
doaj   +1 more source

Discrimination between patients with acquired toxoplasmosis and congenital toxoplasmosis on the basis of the immune response to parasite antigens [PDF]

, 2000
Many persons infected with Toxoplasma gondii develop ocular lesions, Immunologic parameters in the response to I gondii were evaluated in infected persons with and without ocular lesions and in noninfected controls.
Belfort, Rubens Junior, Cunha-Neto, E., Gazzinelli, R. T., Kalil, J., Nussenblatt, R. B., Rizzo, L. V., Silveira, Claudio Alberto Magalhaes, Vallochi, A. L., Yamamoto, J. H.   +8 more
core   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Peripheral Helper Lymphocytes Produce Interleukin 12 in Cancer Patients

Clinical Medicine Insights: Oncology, 2013
The aim of the study was to seek evidence for the production of IL-12 by CD4 + T lymphocytes in in vitro and ex vivo trials. We performed in vitro trials with spleen cells from mice subjected to carcinogenesis, as well as ex vivo trials with cells ...
Márcia A. Michelin, Douglas R. Abdalla, André A.R. Aleixo, Eddie F.C. Murta   +3 more
doaj   +2 more sources