Results 101 to 110 of about 5,344,313 (294)

IL-4 and IL-13 Receptor Signaling From 4PS to Insulin Receptor Substrate 2: There and Back Again, a Historical View

Frontiers in Immunology, 2018
In this historical perspective, written in honor of Dr. William E. Paul, we describe the initial discovery of one of the dominant substrates for tyrosine phosphorylation stimulated by IL-4.
Achsah D. Keegan, Achsah D. Keegan, Jose Zamorano, Aleksander Keselman, Nicola M. Heller   +4 more
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes [PDF]

, 2016
Air pollutants have been linked to type 2 diabetes (T2D), hypothesized to act through inflammatory pathways and may induce interleukin-6 gene (IL6) in the airway epithelium. The cytokine interleukin-6 may impact on glucose homeostasis.
Imboden, Medea, Eze, Ikenna C, von Eckardstein, Arnold, Margaret W. Gerbase, Turk, Alexander, Ikenna C. Eze, Christian Schindler, Eze, Ikenna C., Kumar, Ashish, Probst-Hensch, Nicole, Daiana Stolz, Kronenberg, Florian, Medea Imboden, Adam, Martin, Künzli, Nino, Alexander Turk, Stolz, Daiana, Gerbase, Margaret W, Martin Adam, Nino Künzli, Gerbase, Margaret W., Florian Kronenberg, Nicole Probst-Hensch, Schindler, Christian, Arnold von Eckardstein, Ashish Kumar   +25 more
core   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Correlation between forkhead box P3 (rs3761548) gene polymorphism and serum interleukin13 as biomarkers of severity in Egyptian allergic conjunctivitis: a retrospective study

Frontiers in Allergy
IntroductionThe genetic variants that alter human Forkhead Box P3 (FOXP3) function may have a part in the establishment of allergic conjunctivitis. Our study aimed to evaluate the FOXP3 polymorphism, serum interleukin13 (IL13) and total immunoglobulin E (
Wesam A. Boghdady, Marwa A. Khairy, Ali G. Ali, Alia A. El Shahawy, Eman A. Abdelaziz, Aya A. El Shahawy, Fatma Z. Kamel   +6 more
doaj   +1 more source

Long-term interleukin-6 levels and subsequent risk of coronary heart disease: Two new prospective studies and a systematic review [PDF]

, 2008
Background The relevance to coronary heart disease (CHD) of cytokines that govern inflammatory cascades, such as interleukin-6 (IL-6), may be underestimated because such mediators are short acting and prone to fluctuations.
Kaptoge Stephen, Kaptoge, S., Lennon, L., Danesh, J, Lucy Lennon, Gudnason, Vilmundur, Stephen Kaptoge, Higgins Julian P. T, Wensley, F, Mann, Andrea G, Rumley, A., Sarwar, N, Wood, A, Ann Rumley, Vilmundur Gudnason, Danesh, J., Angleman, Sara B, Wood, A., Gudnason, V., Danesh John, Kaptoge, S, Wensley Frances, Wood, Angela, Lowe, G.D., John Danesh, Eiriksdottir, Gudny, Rumley, Ann, Angleman Sara B, Wensley, Frances, Gudnason Vilmundur, Sara B Angleman, Whincup Peter H, Kaptoge, Stephen, Gordon D O Lowe, Lennon Lucy, Sarwar, Nadeem, Higgins, JPT, Lennon, L, Higgins, J.P.T., Andrea G Mann, Peter H Whincup, Mann, AG, Lowe, GDO, Whincup, PH, Mann Andrea G, Whincup, P.H., Julian P T Higgins, Higgins, Julian PT, Lowe, Gordon DO, Angleman, S.B., Wensley, F., Sarwar, N., Mann, A.G., Eiriksdottir, G, Higgins, JP, Danesh, John, Sarwar Nadeem, Gudnason, V, Angleman, SB, Eiriksdottir, G., Lowe Gordon D. O, Angela Wood, Frances Wensley, Lowe, GD, Whincup, Peter H, Nadeem Sarwar, Eiriksdottir Gudny, Gudny Eiriksdottir, Wood Angela, Lennon, Lucy, Rumley Ann, Rumley, A   +71 more
core   +1 more source

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source

Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain [PDF]

, 2012
Background: Cytokines such as interleukin 6 (IL-6) have been implicated in dual functions in neuropsychiatric disorders. Little is known about the genetic predisposition to neurodegenerative and neuroproliferative properties of cytokine genes.
Domschke, Katharina, Volker Arolt, Walter Heindel, Katharina Domschke, Schoening, Sonja, Bernhard T Baune, Jochen Bauer, Christina Uhlmann, Arolt, V, Heindel, W., Konrad, Carsten, Domschke Katharina, Rauch, AV, Konrad Carsten, Suslow Thomas, Sonja Schöning, Kugel, H., Kugel, Harald, Heindel, W, Heindel, Walter, Konrad, C, Domschke, K, Uhlmann, C., Birosova, E, Udo Dannlowski, Suslow, T., Konrad, C., Baune, Bernhard T., Ohrmann Patricia, Uhlmann, C, Grotegerd Dominik, Patricia Ohrmann, Thomas Suslow, Ohrmann, P, Baune, B., Harald Kugel, Rauch, Astrid V., Astrid V Rauch, Grotegerd, D., Birosova Eva, Dannlowski Udo, Rauch Astrid V, Dannlowski, U, Kugel Harald, Birosova, E., Bauer, Jochen, Grotegerd, D, Grotegerd, Dominik, Arolt Volker, Rauch, A., Suslow, T, Uhlmann Christina, Dannlowski, U., Schöning Sonja, Bauer, J., Eva Birosova, Ohrmann, Patricia, Suslow, Thomas, Birosova, Eva, Kugel, H, Bauer, J, Ohrmann, P., Carsten Konrad, Schoning, S., Baune Bernhard T, Schöning, Sonja, Arolt, Volker, Arolt, V., Uhlmann, Christina, Dannlowski, Udo, Bauer Jochen, Domschke, K., Dominik Grotegerd, Baune, BT, Heindel Walter, Schöning, S   +75 more
core   +2 more sources

Changes in Immune‐Inflammation Status and Prognosis in Pregnancy‐Related Cerebral Venous Thrombosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Distinguishing pathological changes from physiological adaptations in pregnancy‐related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune‐inflammation, and dehydration status in these patients and assess their prognostic value.
Xiaoming Zhang, Zilin Xu, Ran Duan, Chunxiao Lu, Da Zhou, Chen Zhou, Ran Meng, Xunming Ji   +7 more
wiley   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source