Results 111 to 120 of about 4,008,604 (402)
The role of interleukin-17 in tumor development and progression
Journal of Experimental Medicine, 2019 This review discusses the growing literature on the pathogenic role of IL-17 in cancer, focusing on recent studies that place IL-17 as a nexus linking inflammation, tissue repair, and cancer.
Junjie Zhao +3 more
semanticscholar +1 more source
Molecular Oncology, Volume 19, Issue 5, Page 1452-1470, May 2025.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source
Autoimmunity, 2018 A characteristic feature of primary Sjögren’s syndrome (pSS) is the destruction of salivary and lacrimal glands mediated by mononuclear cell infiltration.
Lara A. Aqrawi +8 more
doaj +1 more source
A microbial symbiosis factor prevents intestinal inflammatory disease [PDF]
, 2008 Humans are colonized by multitudes of commensal organisms representing members of five of the six kingdoms of life; however, our gastrointestinal tract provides residence to both beneficial and potentially pathogenic microorganisms.
Kasper, Dennis L. +2 more
core
Investigating the Relationship between Serum Interleukin-17 Levels and Systemic Immune-Mediated Disease in Patients with Dry Eye Syndrome [PDF]
, 2010 Purpose: To investigate the association between dry eye syndrome (DE) and serum levels of interleukin (IL)-17 in patients with systemic immune-mediated diseases.
Abraham +25 more
core +3 more sources
Molecular Oncology, Volume 19, Issue 4, Page 1092-1116, April 2025.FOXL2 c.402C>G mutation drives granulosa cell tumors. Using CRISPR technology, we selectively corrected this mutation, reducing malignancy and increasing sensitivity to dasatinib and ketoconazole. Transcriptomic changes revealed potential therapeutic targets, demonstrating CRISPR's promise for treating this rare ovarian cancer.
Sandra Amarilla‐Quintana +17 more
wiley +1 more source
Targeting the interleukin-17 immune axis for cancer immunotherapy
Journal of Experimental Medicine, 2019 IL-17 plays versatile roles during tumorigenesis. Here, Vitiello and Miller summarize current knowledge in harnessing IL-17–producing γδ and Th17 cells for successful cancer immunotherapy.
G. Vitiello, G. Miller
semanticscholar +1 more source
Targeting of interleukin-17 in the treatment of psoriasis
Clinical, Cosmetic and Investigational Dermatology, 2014 "Psoriasis" is a chronic immune-mediated inflammatory disorder with epidermal hyperplasia. There is some evidence that the cytokine interleukin-17A (often known as IL-17), which is mainly produced by Th17 cells, has a role in the pathogenesis of psoriasis.
Lønnberg, Ann Sophie +2 more
openaire +7 more sources
Molecular Oncology, EarlyView.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
Modeling CD4+ T cells dynamics in HIV-infected patients receiving repeated cycles of exogenous Interleukin 7 [PDF]
arXiv, 2016 Combination Antiretroviral Therapy (cART) succeeds to control viral replication in most HIV infected patients. This is normally followed by a reconstitution of the CD4$^+$ T cells pool; however, this does not happen for a substantial proportion of patients.
arxiv