Results 311 to 320 of about 167,720 (353)

Intracellular Interleukin-1 Receptor Antagonist in Osteoarthritis Chondrocytes

Clinical Orthopaedics and Related Research, 2003
The objective of the current study was to determine whether the balance of interleukin-1 and intracellular interleukin-1 receptor antagonist in chondrocytes in osteoarthritic human joints favors agonist action. Chondrocytes were isolated from cartilage specimens taken at the time of joint arthroplasty.
Minako, Murata, Carol, Trahan, Junichi, Hirahashi, Henry J, Mankin, Christine A, Towle   +4 more
openaire   +2 more sources

Circulating interleukin-1 receptor antagonist levels in neonates

European Journal of Pediatrics, 1996
Circulating interleukin-1 receptor antagonist (IL-1 Ra) levels have been shown to reflect disease activity in certain conditions in adults. We determined circulating IL-1Ra references values for healthy neonates (healthy preterms and term infants with mild disease only) on days 2 (n = 17) and 4 of life (n = 23).
R, Geiger, H, Ellemunter, F M, Fink, M, Falk, H, Tilg   +4 more
openaire   +2 more sources

Interleukin‐1 receptor antagonist in the fetomaternal compartment

Acta Paediatrica, 1995
Interleukin‐1 (IL‐1) is a major mediator in infections and inflammation. Interleukin‐1 receptor antagonist (IL‐1ra) opposes the actions of IL‐1. IL‐1ra is present in exceptionally high concentrations in third trimester amniotic fluid. We studied IL‐1ra in amniotic fluid, fetal serum and newborn urine.
K, Bry, K, Teramo, U, Lappalainen, F, Waffarn, M, Hallman   +4 more
openaire   +2 more sources

Interleukin-1 and Interleukin-1 Receptor Antagonist in Systemic Lupus Erythematosus

Immunological Investigations, 1997
Interleukin-1 (IL-1) is thought to play an important role in the immunopathology of systemic lupus erythematosus (SLE). IL-1 receptor antagonist (IL-1ra) exhibits a dose-responsive inhibition of IL-1 effects, and Fcr receptors play a key role in IL-1ra production.
openaire   +2 more sources

IL1HY1: A Novel Interleukin-1 Receptor Antagonist Gene

Biochemical and Biophysical Research Communications, 1999
Interleukin-1 is a potent mediator of inflammation, involved in regulating a wide variety of physiological and cellular events. We have identified and characterized a novel member of the human interleukin-1 gene family (IL1HY1). The encoded protein demonstrates significant amino acid homology to the receptor antagonist (IL-1ra) at 52%.
J J, Mulero, A M, Pace, S T, Nelken, D B, Loeb, T R, Correa, R, Drmanac, J E, Ford   +6 more
openaire   +2 more sources

Graves' ophthalmopathy and gene polymorphisms in interleukin‐1α, interleukin‐1β, interleukin‐1 receptor and interleukin‐1 receptor antagonist

Clinical & Experimental Ophthalmology, 2009
AbstractPurpose:  Interleukin‐1 (IL‐1) is known to have an important role in pathogenesis of Graves' ophthalmopathy (GO). Polymorphisms in IL‐1 gene have been associated with autoimmune reactions. This study aimed to investigate the association of GO with single‐nucleotide polymorphisms (SNPs) in the IL‐1 family (IL‐1α, IL‐1β, IL‐1 receptor [IL‐1R] and
Omid, Khalilzadeh, Mehdi, Anvari, Alireza, Esteghamati, Mahdi, Mahmoudi, Maryam, Tahvildari, Armin, Rashidi, Farideh, Khosravi, Aliakbar, Amirzargar   +7 more
openaire   +2 more sources

Synovial interleukin‐1 receptor antagonist and interleukin‐1 balance in rheumatoid arthritis

Arthritis & Rheumatism, 1994
AbstractObjective. To quantify interleukin‐1 receptor antagonist (IL‐1ra) and IL‐1 production and gene expression by rheumatoid arthritis (RA) synovial tissue (ST) cells.Methods. IL‐1α, IL‐1β, and IL‐1ra protein levels were measured by enzyme‐linked immunosorbent assay in fresh and cultured ST cells, purified synovial macrophages, and fibroblast‐like ...
G S, Firestein, D L, Boyle, C, Yu, M M, Paine, T D, Whisenand, N J, Zvaifler, W P, Arend   +6 more
openaire   +2 more sources

Expression of interleukin-1 and interleukin-1 receptor antagonists in endometrial cancer

Gynecologic Oncology, 1991
The cytokine interleukin-1 (IL-1) can inhibit growth of breast cancer cells in culture and promote cellular differentiation in synergism with other growth factors. A secreted IL-1 receptor antagonist (sIL-1ra) has been described and an intracellular version (icIL-1ra) has been cloned; both antagonists block IL-1-dependent responses.
L, Van Le, S, Haskill, G J, Jaffe, W C, Fowler   +3 more
openaire   +2 more sources

[Interleukin 1 receptor antagonists].

Pediatrie, 1992
Interleukin 1 (IL-1) is a polypeptide cytokine produced by various cell types that mediates a broad range of biological activities and possesses a wide spectrum of immunologic and non immunologic properties. Interest has recently focussed on the role of IL-1 as an inflammatory mediator in chronic and acute diseases.
openaire   +1 more source

Interleukin-1 receptor antagonist: Discovery, structure and properties

Progress in Growth Factor Research, 1990
Interleukin-1 receptor antagonist (IL-1ra) is a recently-described member of the IL-1 family. This unique human protein has 30% amino acid sequence homology to IL-1 beta and binds to human types I and II IL-1 receptors without apparent cellular activation.
openaire   +2 more sources