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Beneficial Effect of Interleukin-1 Receptor Antagonist Protein on Spinal Cord Injury Recovery in the Rat [PDF]

Inflammation, 2012
We assessed the effect of treatment with the interleukin-1 receptor antagonist protein (IRAP) on morphological and functional recovery in a rat model of SCI. All sections were processed for immunohistochemistry, hematoxylin-eosin, and Nissl staining. Rats were assessed for hind limb motor function using the Basso, Beattie, and Bresnahan (BBB) hind limb
Shaohui Zong, Gaofeng Zeng, Bo Wei, Chunxiang Xiong, Yuxi Zhao   +4 more
semanticscholar   +3 more sources

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Interleukin-1 Receptor Antagonist Protein (IL-1Ra)

, 2009
T. Theodoridis, J. Kraemer
semanticscholar   +2 more sources

Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro.

Diabetes, 1999
The beta-cells in the pancreatic islets of Langerhans are the targets of autoreactive T-cells and are destroyed in type 1 diabetes. Macrophage-derived interleukin-1beta (IL-1beta) is important in eliciting beta-cell dysfunction and initiating beta-cell ...
N. Giannoukakis, W. Rudert, S. Ghivizzani, Andrea Gambotto, Camillo Ricordi, Massimo Trucco, Paul D. Robbins   +6 more
semanticscholar   +1 more source

The effect of an interleukin-1 receptor antagonist protein on type II collagen-induced arthritis and antigen-induced arthritis in mice.

Arthritis & Rheumatism, 1993
OBJECTIVE To investigate the anti-arthritic effect of recombinant human interleukin-1 receptor antagonist protein (IRAP) in two experimental models of arthritis.
P. Wooley, J. Whalen, Darryl L. Chapman, A. E. Berger, Karen A. Richard, D. G. Aspar, N. D. Staite   +6 more
semanticscholar   +1 more source

The mouse interleukin 1 receptor antagonist protein: gene structure and regulation in vitro

Cytokine, 1994
The interleukin 1 receptor antagonist (IL-1ra) protein is an inhibitor of the pro-inflammatory cytokine interleukin 1. We have sequenced the mouse gene encoding the monocyte form of IL-1ra (IL-1rn) and compared it with the sequence of the human homologue.
Alexander S. Whitehead, Clarissa M. Uhlar, Anne E. Prada, Miriam Rits, Kamyar Zahedi   +4 more
openaire   +3 more sources

Interleukin-1 receptor antagonist prevents sepsis-induced inhibition of protein synthesis

American Journal of Physiology-Endocrinology and Metabolism, 1994
To understand the role of interleukin-1 (IL-1) as a mediator of the sepsis-induced skeletal muscle catabolism, we investigated the effects of a specific IL-1 receptor antagonist (IL-1ra) on skeletal muscle protein metabolism in a rodent model of chronic abdominal sepsis.
Thomas C. Vary, J. Vannice, Kelli Gray, Christine V. Jurasinski, E. Owens, Robert N. Cooney   +5 more
openaire   +2 more sources

Genetic Regulation and Activities of an Interleukin 1 Receptor Antagonist Protein

1993
Publisher Summary The cytokine interleukin 1 (IL-1) plays an important role in the response to infection and injury. IL-1 can have positive effects on events in the immune response, including T, B, and natural killer (NK) cell activation. Glucocorticoids inhibit both the synthesis of IL-1 and its action on glucocorticoid-sensitive IL-1-responsive ...
Ann E. Berger, Daniel E. Tracey, Donald B. Carter   +2 more
openaire   +2 more sources

Interleukin-1 receptor antagonist protein inhibits the synthesis of IgE and proinflammatory cytokines by allergen-stimulated mononuclear cells.

American Journal of Respiratory Cell and Molecular Biology, 1994
The ability of interleukin-1 (IL-1) to activate diverse cell populations supports its role as a preeminent cytokine in the pathogenesis of chronic inflammation.
T. Sim, K. Hilsmeier, L. M. Reece, J A Grant, R. Alam   +4 more
semanticscholar   +1 more source

Interleukin-8 secretion and 15-lipoxygenase activity in rheumatoid arthritis: in vitro anti-inflammatory effects by interleukin-4 and interleukin-10, but not by interleukin-1 receptor antagonist protein.

British Journal of Rheumatology, 1994
We have examined the ability of interleukin-4 (IL-4), interleukin-10 (IL-10) and interleukin-1 receptor antagonist protein (IL-1ra) to regulate spontaneous interleukin-8 (IL-8) production in cultured SF mononuclear cells (SFMC) from RA.
Bent Deleuran, L. Iversen, M. Kristensen, M. Field, K. Kragballe, K. thestrup-pedersen, Kristian Stengaard-Pedersen   +6 more
semanticscholar   +1 more source

Purification of Human Recombinant Interleukin 1 Receptor Antagonist Proteins uponBacillus subtilisSporulation

Protein Expression and Purification, 1997
Human interleukin 1 receptor antagonist (IL-1ra) and IL-1ra mutants were constitutively expressed in recombinant Bacillus subtilis in endocellular and active form. In order to optimize the purification of the recombinant proteins, a new method has been developed.
Paolo Ruggiero, Giovanni Macchia, Aldo Tagliabue, Ugo Visconti, Vito Di Cioccio, Paola Bossù, Diana Boraschi, Cinzia Bizzarri, Giovanni Maurizi   +8 more
openaire   +3 more sources