Results 211 to 220 of about 78,083 (294)

Search for novel biomarkers of febrile neutropenia in hematological patients: an overview. [PDF]

Clin Exp Med
Jantunen E, Hämäläinen S, Pulkki K, Juutilainen A.   +3 more
europepmc   +1 more source

The Gut Commensal Butyricimonas Virosa Modulates Gut Microbiota‐Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease

Advanced Science, EarlyView.
This study reveals that dietary stachyose enriches Butyricimonas virosa, effectively attenuating metabolic dysfunction‐associated steatotic liver disease (MASLD). Mechanistically, B. virosa enhances gut thiamine monophosphate synthesis, which elevates hepatic thiamine pyrophosphate levels.
Ningning He, Haoyu Wang, Zizhen Yang, Hui Li, Bei Liu, Kaiwei Chen, Zhinan Wu, Xinnan Zhao, Hewei Liang, Mengmeng Wang, Xiaofang Li, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Karsten Kristiansen, Jixing Peng, Yuanqiang Zou, Shangyong Li   +17 more
wiley   +1 more source

Early trajectory of inflammatory cytokines following tarlatamab administration in three advanced SCLC patients. [PDF]

Cancer Immunol Immunother
Imakita T, Fujita K, Yamamoto Y, Kanai O, Okada Y, Toyama S, Ito T, Oi I, Tanizawa K.   +8 more
europepmc   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Hemophagocytic Lymphohistiocytosis: A Life-Threatening Hyperinflammatory Syndrome. [PDF]

Cureus
Khan T, Arshad L, Huma H, Sidhu MR, George L.   +4 more
europepmc   +1 more source

Biomimetic Organic Nanozyme as Tumor Vaccines for Targeted Suppression of Ammonia‐Induced T Lymphocyte Death to Augment Breast Cancer Immunotherapy

Advanced Science, EarlyView.
The organic nanozyme IR‐IHpd, which has NIR‐PDT and POD‐like activity, is designed for continuous ROS generation. It is co‐encapsulated with CB‐839 and coated with DC membranes to simultaneously target tumors and T cells. Under NIR irradiation, immunogenic cell death is activated. Concurrently, CB‐839 suppresses ammonia‐induced T lymphocyte death (AITD)
Meng Suo, Deyi Yang, Mingpu Yang, Jue Wang, Dingfeng Zhang, Daoming Zhu, Qingyong Xu, Yanni Song   +7 more
wiley   +1 more source

Transient Receptor Potential Channels as Key Regulators of Neuroinflammation in Neurological Disorders: Mechanistic Insights, Therapeutic Potentials, and Future Directions. [PDF]

CNS Neurosci Ther
Guo D, Cai M, Xian Y, Chen Y, Feng Y, Hu C, Zeng L, Shi L, Zhang S.   +8 more
europepmc   +1 more source

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

IL-1 receptor antagonist as a diagnostic biomarker for bacterial infections in acute decompensation of cirrhosis. [PDF]

Sci Rep
Konstantis G, Schütte A, Jung B, Passenberg M, Jacquet L, Guntlisbergen C, Nuruzade N, Hoyer DP, Best J, Willuweit K, Schmidt HH, Guckenbiehl S, Rashidi-Alavijeh J.   +12 more
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source