Results 21 to 30 of about 628,146 (183)

Radiolabeling with fluorine-18 of a protein, interleukin-1 receptor antagonist [PDF]

Applied Radiation and Isotopes, 2010
IL-1RA is a naturally occurring antagonist of the pro-inflammatory cytokine interleukin-1 (IL-1) with high therapeutic promise, but its pharmacokinetic remains poorly documented. In this report, we describe the radiolabeling of recombinant human interleukin-1 receptor antagonist (rhIL-1RA) with fluorine-18 to allow pharmacokinetic studies by positron ...
Prenant, C., Cawthorne, C., Fairclough, M., Rothwell, N., Boutin, H.   +4 more
openaire   +5 more sources

Cardiovascular disease-linked plasma proteins are mainly associated with lung volume

ERJ Open Research, 2023
Background Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been ...
Andreas Rydell, Elisabet Nerpin, XingWu Zhou, Lars Lind, Eva Lindberg, Jenny Theorell Haglöw, Tove Fall, Christer Janson, Karin Lisspers, Sölve Elmståhl, Suneela Zaigham, Olle Melander, Peter M. Nilsson, Johan Ärnlöv, Andrei Malinovschi   +14 more
doaj   +1 more source

Dual biological functions of an interleukin‐1 receptor antagonist–interleukin‐10 fusion protein and its suppressive effects on joint inflammation [PDF]

Immunology, 2004
SummaryThe aim of this study was to construct and purify a novel interleukin‐1 receptor antagonist (IL‐1ra)–interleukin‐10 (IL‐10) fusion protein and determine its biological function and anti‐inflammatory effects. The isolated cDNAs of two inhibitory cytokines (IL‐1ra, IL‐10) were used to construct a cDNA for the IL‐1ra–IL‐10 fusion protein.
Deh‐Ming Chang, Song‐Kun Shyue, Shao‐Hsiang Liu, Yen‐Teen Chen, Chiou‐Yueh Yeh, Jenn‐Huang Lai, Herng‐Sheng Lee, Ann Chen   +7 more
openalex   +5 more sources

Clinical and Functional Results Using Autologous Conditioned Serum in the Treatment of Acute Ankle Injuries in Sporting Activities

Journal of Orthopedic and Spine Trauma, 2022
Background: Ankle ligament injuries in the sports like basketball, volleyball, and cricket are the most common reasons for missed participation in athletics, accounting for 14% of all sports injuries.
Satya Kumar Koduru, Balakrishhna Bathina, Manidhar Sane   +2 more
doaj   +1 more source

IL-1Ra Protects Hepatocytes from CCl4-Induced Hepatocellular Apoptosis via Activating the ERK1/2 Pathway

Pharmaceutical Fronts, 2020
Interleukin-1 receptor antagonist is an important acute-phase protein and an immune mediator, and its expression is associated with the development of hepatitis or acute liver failure.
Ying Zheng, Xinyi Xiao, Zhuoyi Yang, Meiqi Zhou, Hui Chen, Siyi Bai, Jianwei Zhu, Yunsheng Yuan   +7 more
doaj   +1 more source

Defining Potential Therapeutic Targets in Coronavirus Disease 2019: A Cross-Sectional Analysis of a Single-Center Cohort

Critical Care Explorations, 2021
OBJECTIVES:. Multiple mechanisms have been proposed to explain disease severity in coronavirus disease 2019. Therapeutic approaches need to be underpinned by sound biological rationale. We evaluated whether serum levels of a range of proposed coronavirus
Nishkantha Arulkumaran, PhD, Timothy Arthur Chandos Snow, FFICM, Adarsh Kulkarni, MD, David Brealey, PhD, Hannah Rickman, MB BChir, Chloe Rees-Spear, MSc, Moira J. Spyer, PhD, Judith Heaney, PhD, Edmund Garr, PhD, Bryan Williams, PhD, Peter Cherepanov, PhD, George Kassiotis, PhD, Michael Lunn, PhD, Catherine Houlihan, PhD, Laura E. McCoy, PhD, Eleni Nastouli, FRCPath, Mervyn Singer, FRCP   +16 more
doaj   +1 more source

Blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in patients with symptoms suggesting reactive hypoglycemia [PDF]

Brazilian Journal of Medical and Biological Research, 2016
We evaluated the impact of postprandial glycemia on blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in non-diabetic patients with symptoms suggesting reactive hypoglycemia.
W. Eik Filho, S.S. Marcon, T. Krupek, I.T.S. Previdelli, O.C.N. Pereira, M.A.R.C.P. Silva, R.B. Bazotte   +6 more
doaj   +3 more sources

Harnessing thermal fluctuations for selectivity gain [PDF]

2022 IEEE International Symposium on Olfaction and Electronic Nose (ISOEN), 2022, pp. 1-3, 2022
Selectivity of olfactory receptor neuron (ORN) is compared with that of its receptor proteins (R) with fluctuations of odor binding-releasing process taken into account. The binding-releasing process is modeled as N Bernoulli trials, where N is the total number of R per ORN.
arxiv   +1 more source

Anakinra to Mitigate Hemophagocytic Lymphohistiocytosis-Like Toxicity Following Chimeric Antigen Receptor T-cell Therapy in Pediatric B-cell ALL

Clinical Pediatric Hematology-Oncology, 2022
Hemophagocytic lymphohistiocytosis-like toxicity following chimeric antigen receptor (CAR)-T cell therapy (carHLH) is a rare and fulminant complication.
Na Yoon Lee, Suejung Jo, Jae Won Yoo, Seongkoo Kim, Jae Wook Lee, Nack-Gyun Chung, Bin Cho   +6 more
doaj   +1 more source

Change in Eosinophil Count in Patients with Heart Failure Treated with Anakinra

Cells, 2023
Background: Interleukin-1 blockade with anakinra leads to a transient increase in eosinophil blood count (eosinophils) in patients with acute myocardial infarction. We aimed to investigate the effect of anakinra on changes in eosinophils in patients with
Michele Golino, Francesco Moroni, Marco Giuseppe Del Buono, Justin M. Canada, Azita H. Talasaz, Sebastian Piñel, James Mbualungu, Alessandra Vecchiè, Ai-Chen (Jane) Ho, Georgia K. Thomas, Salvatore Carbone, Hayley E. Billingsley, Jeremy Turlington, Roshanak Markley, Cory Trankle, Roberto De Ponti, Benjamin Van Tassell, Antonio Abbate   +17 more
doaj   +1 more source