Results 61 to 70 of about 148,472 (219)

Augmented Cystine–Glutamate Exchange by Pituitary Adenylate Cyclase-activating Polypeptide Signaling via the VPAC1 Receptor [PDF]

, 2014
In the central nervous system, cystine import in exchange for glutamate through system xc- is critical for the production of the antioxidant glutathione by astrocytes, as well as the maintenance of extracellular glutamate. Therefore, regulation of system
Arimura, Ashur-Fabian, Asztely, Baker, Baker, Baker, Bannai, Bannai, Barger, Berman, Brenneman, Brown, Chen, Choi, Costa, Diamond, Dickson, Dugan, Fahrenkrug, Figiel, Fogal, Ghatei, Grant, Grant, Grimaldi, Grimaldi, Groot, Hannibal, Hannibal, Hashimoto, Jackman, Johnson, Joo, Joo, Knackstedt, Kranich, Kupchik, Lewerenz, Liu, Liu, Liu, Liu, Lobner, Macdonald, Magistretti, Martin, Masmoudi-Kouki, Masmoudi-Kouki, Moran, Morio, Murphy, Park, Piani, Pow, Rush, Rush, Sagara, Said, Sato, Schwartz, Seaborn, Shih, Shintani, Sontheimer, Suh, Suzuki, Tatsuno, Tatsuno, Vaudry, Vaudry, Yaka, Ye, Yuhara, Zheng, Zhou   +74 more
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IL-1β-Induced Matrix Metalloprotease-1 Promotes Mesenchymal Stem Cell Migration via PAR1 and G-Protein-Coupled Signaling Pathway

Stem Cells International, 2018
Mesenchymal stem cells (MSCs) are known for homing to sites of injury in response to signals of cellular damage. However, the mechanisms of how cytokines recruit stem cells to target tissue are still unclear.
Ming-Siou Chen, Cheng-Yu Lin, Yun-Hsuan Chiu, Chie-Pein Chen, Pei-Jiun Tsai, Hwai-Shi Wang   +5 more
doaj   +1 more source

Systemic inflammation and protease profile of Afro-Caribbean patients with sepsis

SAGE Open Medicine, 2021
Objectives: Sepsis is one of the leading causes of morbidity and mortality within the healthcare system and remains a diagnostic and therapeutic challenge.
Panid Borhanjoo, Navneet Singh, Sridesh Nath, MD Sadakat Chowdhury, Carl Swanson, Ryan Kaiser, Patrick Geraghty, Robert F Foronjy, Lillian Chow   +8 more
doaj   +1 more source

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. [PDF]

, 2013
Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7) results in an antidepressant phenotype in mice. However, the link between the deficiency of P2rx7 and changes in behavior has not yet been explored.
A McQuillin, A Scimemi, AA Boucher, AD Michel, AJ Law, AM Basso, AN Guerra, AV Gourine, B Sperlagh, B Sperlagh, B Sperlagh, Beáta Sperlágh, BP Guiard, C Csolle, C Delarasse, C Lavebratt, C Toro, C Verderio, Cecilia Csölle, CG Thomas, CM Anderson, DS Hasin, DT Balu, E Castren, E Fuchs, E Mundo, E Shimizu, E. Sylvester Vizi, Edit Papp, EJ Nestler, EK Green, F Frenois, F Karege, Flóra Gölöncsér, G Nagy, G Nowak, G Sanacora, G Sanacora, G Sanacora, Gabriella Zsilla, GE Hardingham, GE Wood, JE Malberg, JF Cryan, JF Cryan, JH Meador-Woodruff, JL Warner-Schmidt, JM Boyce-Rustay, JM Krueger, JO Groves, JS Barnholtz, K Hashimoto, K Hejjas, K Martinowich, K Viwatpinyo, K Wager-Smith, KR Tovar, L Backlund, L Bocchio-Chiavetto, L Papp, L Papp, L Patti, L Santarelli, L Stokes, L Zhang, LM Monteggia, M Baranyi, M Barbera-Cremades, M Diaz-Hernandez, M Grigoroiu-Serbanescu, M Koehl, M Masin, M Solle, ME Kozisek, ME Kozisek, ME Szapacs, ML Barbaccia, MT Miras-Portugal, MW Pfaffl, Mária Baranyi, N Barden, N Drigues, O Berton, OH Lowry, P Fossati, P Skolnick, P Soronen, P Vanhoutte, PA Lapchak, Peter Illes, R Dantzer, RC Hogg, RJ Griffiths, RJ Rodrigues, RS Duman, S Alloisio, S Duan, S Lucae, S Monleon, S Schnydrig, SN Williams, SP Banerjee, T Balazsa, T Deltheil, T Deltheil, T Zigova, Thierry Amédée, V Shukla, VF Labrousse, VM Brautigam, W Peng, Y Dwivedi, Y Shirayama, Z Hracskó, Ágnes Kittel   +114 more
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Induction of the interleukin 1 receptor antagonist protein by transforming growth factor‐β

European Journal of Immunology, 1991
AbstractTransforming growth factor‐β1 (TGF‐β1) mediates many immunosuppressive effects on immune cells and can inhibit the production of tumor necrosis factor and interleukin 1 (IL 1). However, TGF‐β1 can stimulate the production of IL6 and platelet‐derived growth factor, indicating that TGF‐β1 initiates complex effects on the production of cytokines ...
Turner, M, Chantry, D, Katsikis, P, Berger, A, Brennan, F, Feldmann, M   +5 more
openaire   +2 more sources

Interleukin 1 Signaling Is Regulated by Leukemia Inhibitory Factor (LIF) and Is Aberrant in Lif−/− Mouse Uterus [PDF]

, 2008
This study addresses the regulation of the interleukin 1 (IL1) system in the murine uterine luminal epithelium (LE) and stroma by leukemia inhibitory factor (LIF). Using RT-PCR we compared expression of Il1a, Il1b, Il1rn, Il1r1, and Il1r2 during the pre-
Heath, John K
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Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis [PDF]

, 2010
Introduction: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initiating site of the disease ...
Bellantuono, I., Coulton, L., Croucher, P.I., Gambardella, A., Hughes, D., Kottam, L., Mohanty, S.T., Nicklin, M.J., Wilson, A.G.   +8 more
core   +3 more sources

Neonatal-onset multisystem inflammatory disease responsive to interleukin-1 beta inhibition [PDF]

, 2006
BACKGROUND:Neonatal-onset multisystem inflammatory disease is characterized by fever, urticarial rash, aseptic meningitis, deforming arthropathy, hearing loss, and mental retardation.
Adams, BS, Aksentijevich, I, Beitz, LO, Brewer, C, Butman, JA, Canna, SW, Cole, JL, Dailey, NJ, Fuhlbrigge, RC, Gardner, G, Gelabert, A, Goldbach-Mansky, R, Hannan, WP, Haverkamp, MH, Hawkins, PN, Hill, S, Hoffmann, SC, Holland, SM, Horn, W, Jarvis, JN, Jones, J, Karp, BI, Kastner, DL, Kim, HJ, Moore, TL, O'Neil, K, Paul, SM, Penzak, SR, Pham, TH, Pucino, F, Rubin, BI, Shaham, B, Snyder, C, Stein, L, Turner, ML, Vehe, RK, Warren, RW, Wesley, RA, Wiggs, E, Zalewski, C   +39 more
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Gene polymorphisms in primary biliary cirrhosis: association with the disease and hepatic osteopathy [PDF]

, 2007
Genetic factors have been implicated in the pathogenesis of osteoporosis, a common disorder in primary biliary cirrhosis (PBC). Estrogen receptor-alpha gene (ER- ), vitamin-D-receptor gene (VDR) and IL-1-receptor-antagonist gene (IL-1RN) are all ...
Bajnok, Éva, Ferenci, Péter, Lakatos, Péter, Lakatos, Péter László, Szalay, Ferenc, Takács, István, Willheim-Polli, Claudia   +6 more
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Biomarker profiles of acute heart failure patients with a mid-range ejection fraction [PDF]

, 2017
OBJECTIVES: In this study, the authors used biomarker profiles to characterize differences between patients with acute heart failure with a midrange ejection fraction (HFmrEF) and compare them with patients with a reduced (heart failure with a ...
Bloomfield, Daniel M, Cleland, John G.F., Cotter, Gad, Davison, Beth, Dittrich, Howard C, Givertz, Michael M, Hillege, Hans L, Khan, Mohsin A F, Mentz, Robert J, Metra, Marco, O'Connor, Christopher M, Ponikowski, Piotr, Teerlink, John R, Tromp, Jasper, van der Meer, Peter, Van Veldhuisen, Dirk J, Voors, Adriaan A.   +16 more
core   +2 more sources