Results 71 to 80 of about 628,146 (183)
Anakinra for the treatment of COVID-19 patients: a systematic review and meta-analysis
European Journal of Medical Research, 2023 Background At the end of 2021, the European Medicines Agency (EMA) expanded its approval for the recombinant human interleukin-1 (IL-1) receptor antagonist Anakinra for the treatment of COVID-19 patients with elevated soluble urokinase plasminogen ...
Karolina Dahms +5 more
doaj +1 more source
Sequence Evolution, Structure and Dynamics of Transmembrane Proteins: Rhodopsin [PDF]
arXiv, 2023 Rhodopsin is a G-protein coupled receptor found in retinal rod cells, where it mediates monocrhromatic vision in dim light. It is one of the most studied proteins with thousands of reviewed entries in Uniprot. It has seven transmembrane segments, here examined for their hydrophobic character, and how that has evolved from chickens to humans.
arxiv
PLoS ONE, 2021 PurposePseudoexfoliation (PXF) is a unique form of glaucoma characterized by accumulation of exfoliative material in the eyes. Changes in tear profile in disease stages may give us insights into molecular mechanisms involved in causing glaucoma in the ...
Prity Sahay +4 more
doaj +1 more source
Comprehensive Reactive Receiver Modeling for Diffusive Molecular Communication Systems: Reversible Binding, Molecule Degradation, and Finite Number of Receptors [PDF]
, 2016 This paper studies the problem of receiver modeling in molecular communication systems. We consider the diffusive molecular communication channel between a transmitter nano-machine and a receiver nano-machine in a fluid environment. The information molecules released by the transmitter nano-machine into the environment can degrade in the channel via a ...
arxiv +1 more source
Selective delivery of interleukine-1 receptor antagonist to inflamed joint by albumin fusion
BMC Biotechnology, 2012 Background Interleukin-1 receptor antagonist, a cytokine that is highly therapeutic to rheumatoid arthritis and several other inflammatory diseases, exhibits rapid blood clearance and poor retention time on the target in clinical application due to its ...
Liu Mengyuan +6 more
doaj +1 more source
Терапевтический архив, 2009 Aim. To analyse the levels of C-reactive protein (CRP), IL-1, IL-6 and IL-1 receptor antagonist (IRA) in the blood of patients with early gonarthrosis (GA). Material and methods. Clinical, x-ray and arthrosonographic examinations to stage GA, to identify
M S Svetlova +11 more
doaj
Zdorovʹe RebenkaSystemic autoinflammatory diseases (SAIDs) are considered dysregulation disorders of the innate immune system characterized by systemic sterile inflammation independent of infection and autoreactive antibodies or antigen-specific T cells ...
О.В. Шварацька +7 more
doaj +1 more source
Effect of histamine on the electric activities of cerebellar Purkinje cell [PDF]
arXiv, 1999 The effect of histamine (HA) on the electric activities of Purkinje cell (PC) is studied on the cerebellum slice. We find that: (1) HA's main effect on PC is excitative (72.9%); there are also a small amount of PC showing inhibitive (10.2%) or no (16.9%) response to HA.
arxiv
Clinical management and therapy of idiopathic recurrent pericarditis
Clinical Management Issues, 2018 Recurrent pericarditis is defined when pericarditic chest pain reappears after a symptom-free period of at least 4 to 6 weeks and after completion of full-dose anti-inflammatory therapy. Idiopathic pericarditis is the commonest etiology. The diagnosis of
Andrea Assolari +5 more
doaj +1 more source
Mediators of Inflammation, 2015 Cannabinoid Δ9-tetrahydrocannabinol (THC) is effective in treating osteoarthritis (OA), and the mechanism, however, is still elusive. Activation of cannabinoid receptor CB2 reduces inflammation; whether the activation CB2 is involved in THC-induced ...
Lei Yang +4 more
doaj +1 more source