Results 231 to 240 of about 57,029,053 (268)

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

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The association of interleukin-31 polymorphisms with interleukin-31 serum levels and risk of systemic lupus erythematosus

Rheumatology International, 2016
Interleukin-31 (IL-31) is the most recently discovered member of the gp130/IL-6 cytokine family which is produced mainly by activated Th2 cells. IL-31 was proved to play a crucial role in autoimmune and inflammatory diseases such as atopic dermatitis, asthma, cutaneous T cell lymphomas, Kawasaki disease and allergic rhinitis.
Hua-Tuo, Huang, Jian-Ming, Chen, Jing, Guo, Yan, Lan, Ye-Sheng, Wei   +4 more
openaire   +2 more sources

Interleukin 31 is involved in intrahepatic cholestasis of pregnancy

The Journal of Maternal-Fetal & Neonatal Medicine, 2016
Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder characterized by maternal itching and altered liver function. Interleukin (IL)-31 is known to be involved in the pathogenesis of pruritic inflammatory skin diseases. In a three-year period, 13 women with a singleton pregnancy and a diagnosis of intrahepatic cholestasis (ICP) were enrolled ...
BASILE, FRANCESCA, SANTAMARIA, ANGELO, MANNUCCI, CARMEN, RIZZO, LAURA, GANGEMI, Sebastiano, D'ANNA, Rosario, ARCORACI, Vincenzo   +6 more
openaire   +3 more sources

Anti–Interleukin-31 Receptor A Antibody for Atopic Dermatitis

New England Journal of Medicine, 2017
Interleukin-31 may play a role in the pathobiologic mechanism of atopic dermatitis and pruritus. We wanted to assess the efficacy and safety of nemolizumab (CIM331), a humanized antibody against interleukin-31 receptor A, in the treatment of atopic dermatitis.In this phase 2, randomized, double-blind, placebo-controlled, 12-week trial, we assigned ...
Alexander, Egeberg, Jacob P, Thyssen, Jashin J, Wu   +2 more
openaire   +6 more sources

Interleukin 31 and skin diseases: A systematic review

Allergy and Asthma Proceedings, 2017
Although the pathophysiology of pruritus has been extensively studied in recent years, with many resultant advancements, management of pruritus is still enigmatic, particularly in chronic cutaneous diseases, such as atopic dermatitis, chronic urticaria, allergic contact dermatitis, cutaneous T-cell lymphoma, and uremic pruritus.
Gangemi, Sebastiano, Quartuccio, Sebastiano, Casciaro, Marco, Trapani, Giovanni, Minciullo, Paola Lucia, Imbalzano, Egidio   +5 more
openaire   +2 more sources

Interleukin 31 in vitiligo patients with and without pruritus

Acta Dermatovenerologica Alpina Pannonica et Adriatica
Vitiligo is a prevalent skin disorder characterized by the destruction of melanocytes, leading to depigmented patches across various areas of the body. Interleukin (IL)-31 has been implicated in the development of pruritus and skin inflammation, potentially contributing to cutaneous symptoms.
Shaimaa E, Lashin, Olfat G, Shaker, Samar M, El-Tahlawi, Esraa H, Yousef, Sara M, Yaseen   +4 more
openaire   +2 more sources

MicroRNA-31 Negatively Regulates Interleukin-34 Expression In Vitro

Immunological Investigations, 2019
Interleukin-34 (IL-34) is a recently discovered cytokine that promotes tissue macrophage maturation and differentiation. We previously found that 1α,25-Dihydroxyvitamin D3 up-regulated IL-34 expression in SH-SY5Y neural cells. However, whether microRNA regulates IL-34 expression is not completely clear. By using on-line TargetScan and MiRanda software,
Miaomiao Li, Yang Dong, Zhangming Chen, Lei Meng, Xingyun Liu, Xinhui Zhang, Huimin Wang, Weijia Mao, Jie Zhang, Zhe Jiang, Ting Huang, Jie Hu, Panquan Luo, Heinrich Korner, Songcheng Ying, Jun Li   +15 more
openaire   +2 more sources