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Unveiling the multifaceted antitumor effects of interleukin 33 [PDF]

Frontiers in Immunology
Interleukin 33 (IL-33), once predominantly recognized for its pro-tumoral activities, has emerged as a multifunctional cytokine with antitumor properties.
Leire Arrizabalaga, Leire Arrizabalaga, Aline Risson, Aline Risson, Miriam Ezcurra-Hualde, Miriam Ezcurra-Hualde, Fernando Aranda, Fernando Aranda, Pedro Berraondo, Pedro Berraondo, Pedro Berraondo   +10 more
doaj   +2 more sources

Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer [PDF]

Cell Death and Disease
Resistance to DNA damage is one of the primary mechanisms by which tumor cells evade the effects of standard chemotherapeutic agents and radiotherapy. Dynamic and complex interactions between the tumor microenvironment (TME) and tumor cells critically ...
Haoge Luo, Liping Liu, Xiaoping Liu, Yingdong Xie, Xin Huang, Ming Yang, Chen Shao, Dong Li   +7 more
doaj   +2 more sources

Interleukin‐33‐Mediated Mechanical‐Loading Induced Degeneration of Knee Joint Chondrocytes [PDF]

FASEB BioAdvances
Osteoarthritis (OA), a common degenerative joint disorder, continued to present significant challenges in clinical management due to an incomplete understanding of its pathogenesis.
Jiahui Zhang, Yao Sun, Tongtong Chen, Hanqi Wang, Changwei Li, Yong Lu   +5 more
doaj   +2 more sources

Biological mechanisms and therapeutic prospects of interleukin-33 in pathogenesis and treatment of allergic disease [PDF]

Journal of Inflammation
Allergic diseases significantly impact the quality of life of people around the world. Cytokines play a crucial role in regulating the immune system. Due to their importance in pro-inflammatory mechanisms, cytokines are used to understand pathogenesis ...
Mohammad Chand Jamali, Asma’a H. Mohamed, Azfar Jamal, Mohammad Azhar Kamal, Waleed Al Abdulmonem, Bashar Abdullah Saeed, Nasrin Mansuri, Fuzail Ahmad, Mustafa Mudhafar, Alaa Shafie, Haroonrashid M. Hattiwale   +10 more
doaj   +2 more sources

Interleukin-33 and Obesity-Related Inflammation and Cancer [PDF]

Encyclopedia
Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family. It is primarily associated with type 2 immune responses. It interacts with a receptor complex on immune cells in reaction to tissue damage or cellular injury.
Cameron Kowitt, Qiuyang Zhang
doaj   +2 more sources

Interleukin 33: a suitable target for biological therapies of COPD? [PDF]

ERJ Open Research
Corrado Pelaia
doaj   +2 more sources

Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairments

Journal of Neuroinflammation, 2020
Background Interleukin (IL)-33 is expressed in a healthy brain and plays a pivotal role in several neuropathologies, as protective or contributing to the development of cerebral diseases associated with cognitive impairments.
Flora Reverchon, Vidian de Concini, Vanessa Larrigaldie, Sulayman Benmerzoug, Sylvain Briault, Dieudonnée Togbé, Bernhard Ryffel, Valérie F. J. Quesniaux, Arnaud Menuet   +8 more
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INTERLEUKIN 33 AND FIBROSIS: PATHOGENESIS UPDATED

Медицинская иммунология, 2018
Interleukin 33 (IL-33) is a member of the IL-1 family, which is widely expressed on all types of cells. IL-33 was identified as a functional ligand for the plasma membrane receptor complex, which is a heterodimer consisting of a membrane bound ST2 ...
E. G. Uchasova, O. V. Gruzdeva, Yu. A. Dileva, V. N. Karetnikova   +3 more
doaj   +1 more source

Full Length Interleukin 33 Aggravates Radiation-Induced Skin Reaction

Frontiers in Immunology, 2017
The interleukin (IL)-1 family member IL-33 has been described as intracellular alarmin with broad roles in wound healing, skin inflammation but also autoimmunity.
Olga Kurow, Benjamin Frey, Louis Schuster, Verena Schmitt, Susanne Adam, Madelaine Hahn, Derek Gilchrist, Iain B. McInnes, Stefan Wirtz, Udo S. Gaipl, Gerhard Krönke, Georg Schett, Silke Frey, Axel J. Hueber   +13 more
doaj   +1 more source

Comparison of Interleukin-33 serum levels in asthmatic patients with a control group and relation with the severity of the disease

International Journal of Preventive Medicine, 2017
Background: The relation between interleukin-33 (IL-33) and asthma is not precisely known yet. The present study set to compare the serum level of IL-33 in patients with asthma and controls and study the relation with the severity of disease.
Tooba Momen, Hamid Ahanchian, Mohsen Reisi, Seyedeh Azra Shamsdin, Armindokht Shahsanai, Majid Keivanfar   +5 more
doaj   +1 more source