Results 61 to 70 of about 728,843 (299)
Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]
, 2009 Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
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Role of interleukin 33 in chronic rhinosinusitis [PDF]
Thorax, 2017 Chronic rhinosinusitis (CRS) is a heterogenous airways disease characterised by inflammation of the upper airways and sinuses that persists for at least 12 weeks. CRS is frequently divided into two endotypes based on the presence or absence of nasal polyps (NPs): CRS with NPs (CRSwNP) and CRS without NPs (CRSsNP).
openaire +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Clinical Significance of Interleukin 33 (IL-33) in Patients with Eosinophilic Pneumonia
Allergology International, 2013 Background: Interleukin 33 (IL-33) works as a functional mediator in allergic disease by enhancing the activity of eosinophils and inducing expression of T helper 2 (Th2)-associated cytokines.
Naoko Mato +8 more
doaj +1 more source
Comparation between serum levels of interleukin-33 in children with allergic asthma before and after inhalatory corticosteroid treatment [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2020 Introduction/Objective. Interleukin 33 (IL-33) has a very significant function in inflammatory and autoimmune mechanisms, but its significance in immunopathogenic mechanisms of different allergic diseases, including allergic asthma (AA), is becoming ...
Milanović Borko +3 more
doaj +1 more source
Tissue signals imprint ILC2 identity with anticipatory function. [PDF]
, 2018 Group 2 innate lymphoid cells (ILC2s) are distributed systemically and produce type 2 cytokines in response to a variety of stimuli, including the epithelial cytokines interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP).
Eckalbar, Walter L +10 more
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Interleukin 33 expression in human arthritis [PDF]
Annals of the Rheumatic Diseases, 2011 Background and objectives Interleukin 33 (IL-33) is the most recently discovered member of the IL-1 family of cytokines. Recent evidence in human and mouse suggests a role for IL-33 and its receptor T1/ST2 in arthritis. In this study, the authors quantified IL-33 levels in serum and synovial fluid (SF), and assessed synovial IL-33 expression levels ...
Dominique Talabot-Ayer +6 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Frontiers in Immunology, 2020 Background: Eosinophils develop from CD34+ progenitor cells in the bone marrow under the influence of interleukin (IL)-5. Several cell types produce IL-5, including type 2 innate lymphoid cells (ILC2s).
Emma Boberg +5 more
doaj +1 more source
Montmorency cherries reduce the oxidative stress and inflammatory responses to repeated days high-intensity stochastic cycling [PDF]
, 2014 This investigation examined the impact of Montmorency tart cherry concentrate (MC) on physiological indices of oxidative stress, inflammation and muscle damage across 3 days simulated road cycle racing.
Alessio +15 more
core +3 more sources