Results 71 to 80 of about 728,843 (299)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Evidence of association of the NLRP1 gene with giant cell arteritis [PDF]

, 2017
Recent studies have focused attention on the involvement of NLRP1 to confer susceptibility for extended autoimmune/inflammatory disorders, being considered a common risk factor in autoimmunity.
Blanco, Ricardo, Boiardi, Luigi, Carmona, F. David, Castañeda, Santos, Cid Xutglà, M. Cinta, García-Villanueva, María Jesús, González-Gay, Miguel A., Gómez Vaquero, Carmen, Hernández Rodríguez, José, Hidalgo-Conde, Ana, Martín, Javier, Marí-Alfonso, Begoña, Miranda-Filloy, José A., Morado, Inmaculada C., Ortego Centeno, Norberto, Pazzola, Giulia, Prieto González, Sergio, Rodríguez-Rodríguez, Luis, Salvarani, Carlo, Serrano, Aurora, Solans, Roser, Sopeña, Bernardo, Sánchez-Martin, Julio, Unzurrunzaga, Ainhoa   +23 more
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Decreased Interleukin-4 Release from the Neurons of the Locus Coeruleus in Response to Immobilization Stress [PDF]

, 2016
It has been demonstrated that immobilization (IMO) stress affects neuroimmune systems followed by alterations of physiology and behavior. Interleukin-4 (IL-4), an anti-inflammatory cytokine, is known to regulate inflammation caused by immune challenge ...
An, Kyungeh, Lee, Hyun-ju, Park, Hyun-Jung, Shim, Insop, Starkweather, Angela   +4 more
core   +8 more sources

Protein and mRNA expression of interleukin-33 in periodontally diseased and healthy individuals and impact of nonsurgical periodontal therapy in salivary IL-33 levels

Journal of Indian Society of Periodontology, 2023
Background: Interleukin (IL)-33 is a member of IL-1 beta family of cytokines having a pivotal role in bone destruction. However, its role in periodontal disease is not clearly established.
Ambili Renjith, Nisha Sushama Rajan, Shabnas Nazar Shaila   +2 more
doaj   +1 more source

The role of interleukin-33 in organ fibrosis

Discovery Immunology, 2022
Summary Interleukin (IL)-33 is highly expressed in the nucleus of cells present at barrier sites and signals via the ST2 receptor. IL-33 signalling via ST2 is essential for return to tissue homeostasis after acute inflammation, promoting fibrinogenesis and wound healing at injury sites.
Samuele Di Carmine, Molly M Scott, Mairi H McLean, Henry J McSorley   +3 more
openaire   +3 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Differences in Inflammatory Markers between Nulliparous Women Admitted to Hospitals in Preactive vs Active Labor [PDF]

, 2015
Objective To determine whether labor-associated inflammatory markers differ between low-risk, nulliparous women in preactive vs active labor at hospital admission and over time.
Arntzen, Bailit, Banchereau, Bennett, Bennett, Bollapragada, Caughey, Donna O. McCarthy, Golightly, Gotsch, Greig, Gucer, Hamilton, Hebisch, Holm, Holmes, Impey, Jane M. Lamp, Jarocki, Jeremy L. Neal, Kumar, Lin, Loraine T. Sinnott, Mikolajczyk, Mitchell, Nancy K. Lowe, Neal, Neal, Norman, Nowak, Nowak, Opsjln, Osman, Osmers, Papatheodorou, Ragusa, Rahnama, Roh, Romero, Sennstrom, Shannon L. Gillespie, Shynlova, Thomson, Torbe, Tribe, Vitoratos, Vitoratos, Young, Yuan, Zhang, Zhang   +50 more
core   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source