Results 21 to 30 of about 6,454,602 (248)

CD19+CD24highCD27+ B cell and interleukin 35 as potential biomarkers of disease activity in systemic lupus erythematosus patients

Advances in Rheumatology, 2022
Background Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that associates with aberrant activation of B lymphocytes and excessive autoantibodies.
Hui Xiong, Zengqi Tang, Ying Xu, Zhenrui Shi, Zhixuan Guo, Xiuting Liu, Guozhen Tan, Xuechen Ai, Qing Guo   +8 more
doaj   +1 more source

Level of interleukin-35 in patients with idiopathic membranous nephropathy and its predictive value for remission time

Frontiers in Immunology, 2022
ObjectiveAs a member of interleukin-12 family, interleukin-35 (IL-35) plays an important regulatory role in immune response. The relationship between IL-35 and idiopathic membranous nephropathy (IMN) is still unclear, and the purpose of this study is to ...
Na Zhang, Na Zhang, Haoran Dai, Xuan Dong, Xuan Dong, Wenbin Liu, Hanxue Jiang, Hanxue Jiang, Qihan Zhao, Qihan Zhao, Yu Gao, Yu Gao, Zhendong Feng, Zhendong Feng, Zhaocheng Dong, Zhaocheng Dong, Yuehong Hu, Yuehong Hu, Guangrui Huang, Hongliang Rui, Hongliang Rui, Baoli Liu, Baoli Liu   +22 more
doaj   +1 more source

Interleukin-35 and Thymoquinone nanoparticle-based intervention for liver protection against paracetamol-induced liver injury in rats

, 2023
Paracetamol (PAR) is a commonly used antipyretic and analgesic agent, but its excessive usage can induce liver damage and major health consequences.
Sultan Ayesh Mohammed Saghir, Mohammed Abdullah Alshawsh (9760803), Mouaadh Abdelkarim (17541390), Maisa Siddiq Abduh, Saleh Mohammad Aldaqal (17541393), Saleh Mohammad Aldaqal, Mouaadh Abdelkarim, Sultan Ayesh Mohammed Saghir (17541381), Naif Ahmed Al-Gabri, Ahmad Faheem Ahmeda, Ahmad Faheem Ahmeda (17541387), Maisa Siddiq Abduh (16381125), Naif Ahmed Al-Gabri (17541384), Mohammed Abdullah Alshawsh   +13 more
core   +1 more source

Current Research of the Roles of IL-35 in Tumor Progression

Chinese Journal of Lung Cancer, 2016
Interleukin(IL)-35 is a new member of the interleukin-12 superfamily. Since its first report in 2007, IL-35 rapidly became a research highlight in the field of immunology.
Chongbiao HUANG, Ye TIAN, Yan CUI, Jie XU, Liang XIN, Xueling YANG, Daliang QI   +6 more
doaj   +1 more source

Reciprocal Expression of IL-35 and IL-10 Defines Two Distinct Effector Treg Subsets that Are Required for Maintenance of Immune Tolerance

Cell Reports, 2017
Summary: Regulatory T cells (Tregs) can exert their functions through multiple suppressive mechanisms; however, it is unclear how Tregs exactly employ these mechanisms.
Xundong Wei, Jianhua Zhang, Qianchong Gu, Man Huang, Wei Zhang, Jie Guo, Xuyu Zhou   +6 more
doaj   +1 more source

Role of interlekin-35 as a biomarker in patients with newly diagnosed Hashimoto’s thyroiditis

Endocrine Regulations, 2016
Objective. Interleukin-35 (IL-35), an interleukin-12 (IL-12) cytokine family member, is shown to be a potent immunosuppressive and anti-inflammatory cytokine. Inducible regulatory T cells (Tregs) produce IL-35 that mediates the immune inhibitory function
Yilmaz Hakki, Cakmak M., Ceydilek B., Demir C., Aktas A.   +4 more
doaj   +1 more source

Interleukin-35 in autoimmune dermatoses: Current concepts

Open Medicine, 2022
Interleukin-35 (IL-35) is a lately observed cytokine and is part of the IL-12 cytokine family. IL-35 includes two subunits, p35 and Epstein-Barr virus-induced gene 3, and activates subsequent signaling pathways by binding to receptors to mediate signal ...
Xie Yuming, Zhang Huilin, Huang Junke, Zhang Qing   +3 more
doaj   +1 more source

Differential regulation of interleukin-17 and interferon-y production in inflammatory bowel disease [PDF]

, 2010
PhDBackground and Aims. Interleukin (IL)-17 is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel disease (IBD) are still unclear. Methods.
Rovedatti, Laura
core   +4 more sources

High interleukin-35 expression is associated with the severity of rheumatic mitral stenosis

Frontiers in Immunology
BackgroundRheumatic mitral stenosis (RMS) is the most common manifestation of rheumatic heart disease, with high morbidity and mortality. Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine associated with many autoimmune diseases.
Ping Wang, Yaxiong Li, Li Zhao, Bin Liu, Zhibin Cai, Peng Zhang, Peng Li, Xuezhen Gao, Yong Zhan   +8 more
doaj   +1 more source

Interleukin-35 on B cell and T cell induction and regulation

Journal of Inflammation, 2017
Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transduction of IL-35, the regulation effect of IL ...
Ai Huang, Lin Cheng, Miao He, Jun Nie, Jianjun Wang, Ke Jiang   +5 more
doaj   +1 more source