Results 151 to 160 of about 10,292,063 (293)

Targeting Interleukin-6 for Treatment of CKD and Cardiovascular Disease. [PDF]

Kidney Int Rep
Tuttle KR, Cherney DZ, Pecoits-Filho R, Pirro M, Yau K, Sahay M.   +5 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

The association between cerebrospinal fluid interleukin-6, soluble interleukin-6 receptor, and interleukin-6 trans-signalling binary complex with postoperative delirium: an observational cohort study. [PDF]

BJA Open
Wu JG, Taylor J, Kunkel D, Maze M, Pearce RA, Sanders RD, Lennertz R.   +6 more
europepmc   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Clinical Use of Interleukin-6 Blockade in Neuroimmunological Disorders. [PDF]

Noro Psikiyatr Ars
Erdal M, Arı A, Emekli AS, Yılmaz NÇ, Kürtüncü M.   +4 more
europepmc   +1 more source

Interleukin gének relatív expressziós szintjének változása ellés előtti D-vitamin kezelés hatására holstein-fríz tehenek méhlepényében

, 2018
A dolgozatomban a D-vitamin többlet bevitel hatását vizsgáltam három gén (IL 1ß, IL6, IL10) vizsgálatával. A vizsgálatunk célja a D-vitaminos kezelés hatására megállapítani az expressziós szintet, a tejelő holstein-fríz tehenek placentájából vett mintái ...
Biszku, Barbara Ildikó
core  

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Treatment of severe covid-19 with interleukin 6 receptor inhibition

BMJ Medicine, 2022
Stephen Burgess, Dipender Gill, Skanda Rajasundaram   +2 more
doaj   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Interleukin-6 in complications of prematurity: from biomarker to targeted therapy. [PDF]

Front Pediatr
Xiao S, Zheng Q, Wang L, Wang Z, Bi G, Yang J.   +5 more
europepmc   +1 more source