Results 81 to 90 of about 9,696,955 (392)

A roadmap to target interleukin-6 in osteoarthritis

Rheumatology, 2020
Joint inflammation is present in the majority of OA patients and pro-inflammatory mediators, such as IL-6, are actively involved in disease progression. Increased levels of IL-6 in serum or synovial fluid from OA patients correlate with disease incidence
R. Wiegertjes, F. V. D. van de Loo, E. B. Blaney Davidson   +2 more
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Comparison of spleen characterization and plasma levels of interleukin 6 and 10 in obese and healthy individuals [PDF]

Journal of Shahrekord University of Medical Sciences
Background and aims: Spleen is one of the organs that has great importance in Iranian traditional medicine due to its relationship with obesity. Therefore, in this study, we aim to investigate spleen characterization and plasma levels of interleukin 6 ...
Mahdis Tanzifi, Mohammad Yousofpour, Amirsaeed Hosseini, Jamshid Yazdani Chrati, Tahereh Amirian   +4 more
doaj   +1 more source

Interleukin (IL-6) Immunotherapy [PDF]

Cold Spring Harbor Perspectives in Biology, 2017
Interleukin 6 (IL-6) is a prototypical cytokine for maintaining homeostasis. When homeostasis is disrupted by infections or tissue injuries, IL-6 is produced immediately and contributes to host defense against such emergent stress through activation of acute-phase and immune responses.
Toshio, Tanaka, Masashi, Narazaki, Tadamitsu, Kishimoto   +2 more
openaire   +2 more sources

Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma

Frontiers in Endocrinology, 2019
The immune system is strongly linked to the maintenance of healthy bone. Inflammatory cytokines, specifically, are crucial to skeletal homeostasis and any dysregulation can result in detrimental health complications.
Danielle Harmer, C. Falank, M. Reagan
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Expression of interleukin 1-alpha, interleukin 6 and CD 10 in predicting recurrence of ameloblastoma

Discover Oncology
Purpose Ameloblastoma (AM) is a clinically significant odontogenic tumour known for its local invasive and high post-treatment recurrence risk. Despite advancements in surgical techniques, predicting recurrence remains challenging.
Nurhazwani Mohd Danil, Bogahawatte Samarakoon Mudiyanselage Samadarani Siriwardena, Yet Ching Goh, Wanninayake Mudiyanselage Tilakaratne   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The Significance of Serum and Fecal Levels of Interleukin-6 and Interleukin-8 in Hospitalized Children with Acute Rotavirus and Norovirus Gastroenteritis

Pediatrics and Neonatology, 2014
Rotavirus and norovirus are the most common known causes of viral gastroenteritis in children. This study examined the association between serum interleukin 6 (IL-6) and interleukin 8 (IL-8) levels and disease severity in the acute phase of rotavirus and
Shan-Ming Chen, Ching-Pin Lin, Jeng-Dau Tsai, Yu-Hua Chao, Ji-Nan Sheu   +4 more
doaj   +1 more source

High Interleukin-6, Low Cd4+ and Cd8+ T-lymphocytes Expressions as Risk Factors of Cervical Carsinoma Infected by Human Papilloma Virus Type-52 [PDF]

, 2013
In Indonesia cervical carcinoma is the most common cancer in women and one of the leading cause of mortality. High risk human papillomavirus (HPV) is the major risk factor of cervical cancer.
Alit-Artha, A. I. (and), Joewarini, E. (E), Mahendra-Dewi, I. G. (I), Suwiyoga, I. K. (I)   +3 more
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