Results 91 to 100 of about 190,327 (265)

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Self‐Feeding of Engineered Tissues via Controlled Glucose Release Facilitates Survival and Vascularization of Living Implants

Advanced Functional Materials, EarlyView.
ABSTRACT Engineering living matter has great clinical potential to deliver functional replacement organs. However, clinical translation remains hampered by the current inability to maintain viability of clinically relevant‐sized constructs. During the pre‐vascular phase, implants rely on nutrient diffusion for survival, which is insufficient at ...
Melvin Gurian, Iris E. Allijn, Laura Veenendaal, Nicole Bassous, Su Ryon Shin, Jeroen Leijten   +5 more
wiley   +1 more source

Modulation of CD4 ⁺ and CD8 ⁺ T Cell Function and Cytokine Responses in Strongyloides stercoralis Infection by Interleukin-27 (IL-27) and IL-37 [PDF]

, 2017
Anuradha Rajamanickam, Saravanan Munisankar, Yukthi Bhootra, Chandrakumar Dolla, Paul Kumaran, Thomas B. Nutman, Subash Babu   +6 more
openalex   +1 more source

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Study of circulating Th17 cells and associated cytokines in myasthenia gravis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Objective To investigate the expression of helper T cell 17 (Th17) cells and associated cytokines in patients with myasthenia gravis (MG) and its correlations to the level of anti-acetylcholine receptor (AChR) antibodies.
Yu-han GAO, Hai-qiang JIN, Hong-jun HAO, Yong-an SUN, Feng GAO   +4 more
doaj  

Mysterious Linkages Between Hepatitis C Virus Genotypes, Interleukin-28B Genotypes and Viral Clearance- A Meta-Analysis [PDF]

, 2014
Seyed Hossein Aalaei-Andabili, Bita Behnava, Shima Salimi, Heidar Sharafi, Seyed Moayed Alavian   +4 more
openalex   +1 more source

Expression Analysis of Interleukin-13 Gene in the Small Intestine of Three Genotypes of chickens Administered Conventional Antibiotics and Garlic

, 2023
Okenyi Nj, Ndofor-Foleng Hm, Tchoupou-Tchoupou Ec, Nnanna Ephraim Ikeh, Nwenya Jm, Amaefule Bc, Uberu Cpn, Nwosu Ic, Onyimonyi Ae, B Abdellatif, C Mcveigh, G Bendriss, A Chaari, J Ansary, T Forbes-Hernndez, E Gil, D Cianciosi, J Zhang, M Elexpuru-Zabaleta, J Simal-Gandara, F Giampieri, M Battino, Y Attia, M Rahman, M Hossain, S Basiouni, A Khafaga, A Shehata, H Hafez, R Bailey, H Cheng, M Chase-Topping, J Mays, O Anacleto, J Dunn, A Doeschl-Wilson, A Elbaz, N Ibrahim, A Shehata, N Mohamed, Abdel-Moneim Am, A Elbaz, E Ashmawy, A Salama, Abdel Moneim, Ame Badri, F Thabet, H, K Felisbino, J Granzotti, L Bello-Santos, Guiloski Ic, S Fulla, R Goel, S Apostolidis, M Painter, D Mathew, A Pattekar, O Kuthuru, E Wherry, L Horev-Azaria, E Shlomit, Nira Iv, P Sarah, M David, Talia, Aharon Rabinkov, Meir, Jasmine, Ninette Naphtali, S, O Iyasere, O Ajayi, S Alade, V Akinbode, K Livak, Schmittgen Td, S Maggini, Pierre Calder, P, I Malgwi, V Halas, P Grnvald, S Schiavon, I Jcsk, S Mandal, A Das, S Dey, U Sahoo, S Bose, A Bose, M Ramadan, C Mckenzie, J Tan, L Macia, C Mackay, H Ndofor-Foleng, V Oleforuh-Okoleh, G Musongong, J Ohageni   +99 more
openalex   +1 more source

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

In silico identification of Shigella sonnei hypothetical protein RUK71877.1 as interleukin receptor mimic Protein A and a potential drug target [PDF]

, 2022
Foeaz Ahmed, Nadim Ahmed, Anindita Ash Prome, Tanjin Barketullah, Nurul Amin, R Laskowski, Jac Rullmann, M Macarthur, R Kaptein, J Thornton, S Lu, J Wang, F Chitsaz, M Derbyshire, R Geer, N Gonzales, M Gwadz, D Hurwitz, G Marchler, J Song, G Lubec, L Afjehi-Sadat, J-W Yang, Jpp John, D Moriel, B Heras, J Paxman, A Lo, L Tan, M Sullivan, S Dando, S Beatson, G Ulett, M Schembri, Muthuirulandi Sethuvel, D, Devanga Ragupathi, N Anandan, S Veeraraghavan, B, T Niwa, B-W Ying, K Saito, Jin Takada, S Ueda, T Taguchi, H, W Pearson, D Lipman, M Rabbi, S Akter, M Hasan, A Amin, V Singh, P Dhankhar, V Dalal, S Tomar, P Kumar, C Thompson, P Duy, S Baker, Pbs Varma, Y Adimulam, S Kodukula, A Waterhouse, J Procter, D Martin, M Clamp, G Barton, M Wiederstein, M Sippl, Y Yan, H Tao, J He, S-Y Huang, C Yu, C Lin, J Hwang, W Zheng, C Zhang, Y Li, R Pearce, E Bell, Y Zhang   +83 more
openalex   +1 more source

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, EarlyView.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source