Results 81 to 90 of about 555,638 (360)

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

Role of interleukins in heart failure with reduced ejection fraction

Anatolian journal of cardiology, 2019
Heart failure (HF) is the leading cause of morbidity and mortality in developed countries, and it is the primary cause of mortality in the elderly worldwide.
O. Segiet, A. Piecuch, Ł. Mielańczyk, M. Michalski, E. Nowalany-Kozielska   +4 more
semanticscholar   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Entamoeba histolytica Calreticulin Induces the Expression of Cytokines in Peripheral Blood Mononuclear Cells Isolated From Patients With Amebic Liver Abscess

Frontiers in Cellular and Infection Microbiology, 2018
Calreticulin (CRT) is a highly conserved protein in the endoplasmic reticulum that plays important roles in the regulation of key cellular functions. Little is known about the participation of E.
Enrique Gonzalez Rivas, Cecilia Ximenez, Miriam Enriqueta Nieves-Ramirez, Patricia Moran Silva, Oswaldo Partida-Rodríguez, Eric Hernandez Hernandez, Liliana Rojas Velázquez, Angelica Serrano Vázquez, Ulises Magaña Nuñez   +8 more
doaj   +1 more source

Tumor-related interleukins: old validated targets for new anti-cancer drug development

Molecular Cancer, 2017
In-depth knowledge of cancer molecular and cellular mechanisms have revealed a strong regulation of cancer development and progression by the inflammation which orchestrates the tumor microenvironment.
Sarra Setrerrahmane, Hanmei Xu
semanticscholar   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Swollen Feet: Considering the Paradoxical Roles of Interleukins in Nephrotic Syndrome

Biomedicines
Interleukins are a family of 40 bioactive peptides that act through cell surface receptors to induce a variety of intracellular responses. While interleukins are most commonly associated with destructive, pro-inflammatory signaling in cells, some also ...
Maria E. Kovalik, Monique A. Dacanay, Steven D. Crowley, Gentzon Hall   +3 more
doaj   +1 more source

Systemic interleukins levels in community-acquired pneumonia and their association with adverse outcomes

Romanian Journal of Laboratory Medicine, 2019
Introduction: Community-acquired pneumonia (CAP) is still one of the major causes of morbidity and mortality worldwide. Pro-inflammatory and anti-inflammatory interleukins have been studied to elucidate the role that inflammation plays in its ...
Tripon Raluca Elena, Neagoe Ioana Berindan, Budisan Livia, Pop Tudor Lucian, Cristea Victor, Stanca Liana Maria, Lupse Mihaela Sorina   +6 more
doaj   +1 more source

Serum Inflammatory Profile for the Discrimination of Clinical Subtypes in Parkinson's Disease

Frontiers in Neurology, 2018
Background: Blood levels of immune markers have been proposed to discriminate patients with Parkinson's disease (PD) from controls. However, differences between clinical PD subgroups regarding these markers still need to be identified.Objective: To ...
Rezzak Yilmaz, Antonio P. Strafella, Antonio P. Strafella, Antonio P. Strafella, Antonio P. Strafella, Antonio P. Strafella, Antonio P. Strafella, Alice Bernard, Claudia Schulte, Claudia Schulte, Lieneke van den Heuvel, Lieneke van den Heuvel, Nicole Schneiderhan-Marra, Thomas Knorpp, Thomas O. Joos, Frank Leypoldt, Frank Leypoldt, Johanna Geritz, Clint Hansen, Sebastian Heinzel, Anja Apel, Anja Apel, Thomas Gasser, Thomas Gasser, Anthony E. Lang, Anthony E. Lang, Anthony E. Lang, Anthony E. Lang, Anthony E. Lang, Daniela Berg, Daniela Berg, Daniela Berg, Walter Maetzler, Walter Maetzler, Walter Maetzler, Connie Marras, Connie Marras   +36 more
doaj   +1 more source

Interleukins Associated with Breast Cancer

Cureus, 2018
A tumor consists of a group of cells with abnormal growth, capable of acquiring unique characteristics that provide them with the ability to display mercurial migration patterns, adapting to microenvironments and their chemical and physical factors ...
Z. Fasoulakis, G. Kolios, Valentinos Papamanolis, E. Kontomanolis   +3 more
semanticscholar   +1 more source