Results 61 to 70 of about 104,417 (205)

The N-terminal domain of Escherichia coli RecA have multiple functions in promoting homologous recombination

Journal of Biomedical Science, 2009
Escherichia coli RecA mediates homologous recombination, a process essential to maintaining genome integrity. In the presence of ATP, RecA proteins bind a single-stranded DNA (ssDNA) to form a RecA-ssDNA presynaptic nucleoprotein filament that captures ...
Wang Ting-Fang, Lee Chien-Der
doaj   +1 more source

GFAP at 50

ASN Neuro, 2020
Fifty years have passed since the discovery of glial fibrillary acidic protein (GFAP) by Lawrence Eng and colleagues. Now recognized as a member of the intermediate filament family of proteins, it has become a subject for study in fields as diverse as ...
Albee Messing, Michael Brenner
doaj   +1 more source

A new function for the serine protease HtrA2 in controlling radiation‐induced senescence in cancer cells

Molecular Oncology, 2022
Radiation therapy can induce cellular senescence in cancer cells, leading to short‐term tumor growth arrest but increased long‐term recurrence. To better understand the molecular mechanisms involved, we developed a model of radiation‐induced senescence ...
Liat Hammer, Vered Levin‐Salomon, Naama Yaeli‐Slonim, Moria Weiss, Naama P. Dekel‐Bird, Tsviya Olender, Ziv Porat, Sabina Winograd‐Katz, Alon Savidor, Yishai Levin, Shani Bialik, Benjamin Geiger, Adi Kimchi   +12 more
doaj   +1 more source

Comprehensive in silico analyses of keratin heterodimerisation

European Journal of Cell Biology
Keratins are the largest and most diverse group of intermediate filament proteins, providing structural integrity and mechanical strength to epithelial cells.
Nicole Schwarz, Rudolf E. Leube, Stefan Düsterhöft   +2 more
doaj   +1 more source

A knock-in mouse model for the R120G mutation of αB-crystallin recapitulates human hereditary myopathy and cataracts. [PDF]

PLoS ONE, 2011
An autosomal dominant missense mutation in αB-crystallin (αB-R120G) causes cataracts and desmin-related myopathy, but the underlying mechanisms are unknown. Here, we report the development of an αB-R120G crystallin knock-in mouse model of these disorders.
Usha P Andley, Paul D Hamilton, Nathan Ravi, Conrad C Weihl   +3 more
doaj   +1 more source

Microscopic basis for pattern formation and anomalous transport in two-dimensional active gels

, 2010
Active gels are a class of biologically-relevant material containing embedded agents that spontaneously generate forces acting on a sparse filament network.
Briels, W. J., Gompper, Gerhard, Head, David A.   +2 more
core   +1 more source

The glycolytic enzyme phosphofructokinase-1 assembles into filaments. [PDF]

, 2017
Despite abundant knowledge of the regulation and biochemistry of glycolytic enzymes, we have limited understanding on how they are spatially organized in the cell.
Albe, Anne M. Dosey, Attanasio, Barry, Beaty, Beckner, Bradley A. Webb, Brüser, Clarke, Cohen, De Bock, Diane L. Barber, Egelman, Egelman, Eisenberg, Foe, Frey, Gunning, Habrian, Ingerson-Mahar, Jang, Jia, Justin M. Kollman, Kemp, Kim, Lander, Li, Liu, Mahboubi, Meredith, Noree, Olsen, O’Connell, Ranjit, Reinhart, Rohou, Scheres, Scheres, Schindelin, Segall, Shaikh, Shen, Sievers, Stehbens, Stehbens, Suloway, Torsten Wittmann, Trujillo, Wang, Webb   +49 more
core   +1 more source

Intermediate Filaments in Motion: Observations of Intermediate Filaments in Cells Using Green Fluorescent Protein-Vimentin [PDF]

Molecular Biology of the Cell, 1999
In the movies presented in this essay we have demonstrated that IFs are dynamic in nature. Movements of IFs include both extension and retraction and are dependent on the presence of intact MTs. Furthermore, we have characterized a possible intermediate of IF turnover, IF fragments.
J L, Martys, C L, Ho, R K, Liem, G G, Gundersen   +3 more
openaire   +2 more sources

Force-induced recruitment of cten along keratin network in epithelial cells. [PDF]

, 2019
The cytoskeleton provides structural integrity to cells and serves as a key component in mechanotransduction. Tensins are thought to provide a force-bearing linkage between integrins and the actin cytoskeleton; yet, direct evidence of tensin's role in ...
Cheah, Joleen S, Heinrich, Volkmar, Jacobs, Kyle A, Lo, Su Hao, Yamada, Soichiro   +4 more
core  

Organization and instabilities of entangled active polar filaments

, 2002
We study the dynamics of an entangled, isotropic solution of polar filaments coupled by molecular motors which generate relative motion of the filaments in two and three dimensions. We investigate the stability of the homogeneous state for constant motor
Liverpool, Tanniemola B., Marchetti, M. Cristina   +1 more
core   +2 more sources