Results 71 to 80 of about 948,768 (269)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Phenotypic and functional properties of HLA-DRhi intermediate monocytes in health and chronic kidney disease

, 2022
Chronic kidney disease (CKD) is a common condition, characteristed by reduced renal function and frequently associated with progressive loss of glomerular filtration, ultimately reaching end stage renal disease (ESRD).
Cormican, Sarah
core   +1 more source

Altered co-stimulatory and inhibitory receptors on monocyte subsets in patients with visceral leishmaniasis.

PLoS Neglected Tropical Diseases
Visceral leishmaniasis (VL) is a neglected tropical disease caused by parasites from the Leishmania (L.) donovani complex. VL is characterised by uncontrolled parasite replication in spleen, liver and bone marrow, and by an impaired immune response and ...
Emebet Adem, Endalew Yizengaw, Tadele Mulaw, Endalkachew Nibret, Ingrid Müller, Yegnasew Takele, Pascale Kropf   +6 more
doaj   +1 more source

CD56 and Tim-3 molecule expression in different monocyte subsets in physiological pregnancy

Медицинская иммунология, 2023
Monocytes play an important role in the systemic immune defense against pathogens and maintaining physiological pregnancy. During pregnancy peripheral monocytes migrate into the decidua and form the pool of decidual macrophages which participate in the ...
E. G. Orlova, O. A. Loginova
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Peripheral Classic and Intermediate Monocyte Subsets as Immune Biomarkers of Systemic Lupus Erythematosus Disease Activity

Acta Medica Indonesiana
Background: Monocytes are evolutionarily preserved innate immune cells that play essential roles in immune response regulation. Three activated monocyte subsets—classical (CD14++CD16–), intermediate (CD14++CD16+), and nonclassical (CD14+CD16++)—are ...
Amaylia Oehadian, Mohammad Ghozali, Sutiadi Kusuma, Lusi Mersiana, Nadia Gita Ghassani, Fransisca Fransisca, Yitzchak Millenard Sigilipu, Andini Kartikasari, Laniyati Hamijoyo   +8 more
doaj   +2 more sources

Differential expression of TNFR1 (CD120a) and TNFR2 (CD120b) on subpopulations of human monocytes

Journal of Inflammation, 2012
Background Three subpopulations of monocytes can be distinguished in human blood: classical (CD14++CD16−), intermediate (CD14++CD16+), and nonclassical (CD14+CD16++).
Hijdra Daniëlle, Vorselaars Adriane DM, Grutters Jan C, Claessen Anke ME, Rijkers Ger T   +4 more
doaj   +1 more source

Intermediate CD14++CD16+ monocytes decline after transcatheter aortic valve replacement and correlate with functional capacity and left ventricular systolic function. [PDF]

PLoS ONE, 2017
Transcatheter aortic valve replacement (TAVR) is the method of choice for patients with severe aortic valve stenosis, who are ineligible or at high risk for surgery.
Jonas Neuser, Paolo Galuppo, Daniela Fraccarollo, Jens Willig, Tibor Kempf, Dominik Berliner, Johann Bauersachs, Julian Daniel Widder   +7 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Monocytes/macrophages express CCR9 in rheumatoid arthritis and CCL25 stimulates their differentiation [PDF]

, 2010
Introduction: Monocytes/macrophages accumulate in the rheumatoid (RA) synovium where they play a central role in inflammation and joint destruction. Identification of molecules involved in their accumulation and differentiation is important to inform ...
Buckley, Christopher, Helen Williams, Cartwright, A, John HH Williams, Andrew Filer, Schmutz, Caroline, Oliver Haworth, Filer, Andrew, Mike Salmon, Haworth, O, Buckley, Christopher D., Alison Cartwright, Christopher D Buckley, Schmutz, C, Williams, John H. H., Middleton, J, Haworth, Oliver, Buckley, CD, Williams, JH, Cartwright, Alison, Caroline Schmutz, Williams, HJ, Middleton, Jim F., Williams, Helen, Salmon, Mike, Filer, A, Salmon, M, Williams, J, Williams, H, Middleton, Jim F S, Jim Middleton   +30 more
core   +1 more source