Results 51 to 60 of about 17,595 (163)

Preservation of TSPO by chronic intermittent hypobaric hypoxia confers antiarrhythmic activity [PDF]

Journal of Cellular and Molecular Medicine, 2011
AbstractAbnormal activation of mitochondrial translocator protein (TSPO) contributes to arrhythmogenesis during cardiac metabolic compromise; however, its role in the antiarrhythmic activities of chronic hypoxia adaptation remains unclear. Our results demonstrated that 80% of normoxic rats developed ischaemic VF, whereas this condition was seldom ...
Li, Jun, Xu, Jiahong, Xiao, Junjie, Zhang, Hong, Liang, Dandan, Liu, Yi, Zhang, Yangyang, Liu, Ying, Wen, Wei, Hu, Yaer, Yu, Zhuo, Yan, Biao, Jiang, Bing, Zhou, Zhao-Nian, Chen, Yi-Han   +14 more
openaire   +2 more sources

Adenosine mono-phosphate-activated protein kinase-mammalian target of rapamycin signaling participates in the protective effect of chronic intermittent hypobaric hypoxia on vascular endothelium of metabolic syndrome rats

Chinese journal of physiology, 2022
Our previous study demonstrated that chronic intermittent hypobaric hypoxia (CIHH) protects vascular endothelium function through ameliorating autophagy in mesenteric arteries of metabolic syndrome (MS) rats.
Fang Cui, Min Shi, Hao-Fei Hu, Yan-Ming Tian, Chen-ming Zhou, H. Mi, Shuo Gu, Zan Guo, Xiang-Jian Zhang, Yi Zhang   +9 more
semanticscholar   +1 more source

Blood Rheology Adjustments in Rats after a Program of Intermittent Exposure to Hypobaric Hypoxia [PDF]

High Altitude Medicine & Biology, 2009
Intermittent hypobaric hypoxia (IHH) exposure induces a rise in hemoglobin concentration and an increase in erythrocyte mass in both rats and humans. Although this response increases blood oxygen transport capacity, paradoxically, it could impair blood flow and gas exchange because of the blood viscosity alterations associated with the rising ...
Esteva i Gras, Santiago, Panisello Tafalla, Pere, Torrella Guio, Joan Ramon, Pagés, Teresa, Viscor Carrasco, Ginés   +4 more
openaire   +3 more sources

Low altitude simulation without hypoxia improves left ventricular function after myocardial infarction by reducing ventricular afterload.

PLoS ONE, 2019
Humans have a lower risk of death from myocardial infarction (MI) living at low elevations (5000 m, and intermittent hypobaric hypoxia post-MI can reduce MI size in rodents, and it is believed that hypoxia is the key stimulus.
Anmol Shahid, Vaibhav B Patel, Jude S Morton, Trevor H Stenson, Sandra T Davidge, Gavin Y Oudit, Michael S McMurtry   +6 more
doaj   +1 more source

A study of survival strategies for improving acclimatization of lowlanders at high-altitude

Heliyon, 2023
Human Acclimatization and therapeutic approaches are the core components for conquering the physiological variations at high altitude (≥2500 m) exposure.
Poornima Sharma, Swaraj Mohanty, Yasmin Ahmad   +2 more
doaj   +1 more source

Chronic Intermittent Hypobaric Hypoxia Prevents Contrast-Induced Acute Kidney Injury By Modulating The HIF-1α Signaling Pathway

bioRxiv, 2022
The aim of this study was to explore the role of CIHH in preventing contrast-induced acute kidney injury (CI-AKI) in rats and its mechanism. Rats mean arterial pressure, heart rate, serum creatinine and blood urea nitrogen levels were measured.
Kai Yin, Yanying Ni, G. Cao, Jia-yuan Zhang, Bao-jun Yi, Ziqiang Pang, Hui-jie Ma, Li Zhang   +7 more
semanticscholar   +1 more source

Effects of intermittent exposure to hypobaria and cold on the microarchitecture and morphofunctional profile of rat gastrocnemius muscle

The Anatomical Record, EarlyView.
Abstract Intermittent hypobaric hypoxia (IHH) enhances oxygen transport, muscle metabolism, and cardiovascular health; however, the combined effects of hypobaria and cold are less well understood. Exposure to these stressful environmental factors, even intermittently, can affect skeletal muscle due to its plasticity, thereby altering its metabolic and ...
Garoa Santocildes, Teresa Pagès, Ginés Viscor, Joan Ramon Torrella   +3 more
wiley   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Combined intermittent hypoxia and surface muscle electrostimulation as a method to increase peripheral blood progenitor cell concentration

Journal of Translational Medicine, 2009
Background Our goal was to determine whether short-term intermittent hypoxia exposure, at a level well tolerated by healthy humans and previously shown by our group to increase EPO and erythropoiesis, could mobilize hematopoietic stem cells (HSC) and ...
Azqueta Carmen, Martin-Henao Gregorio, Ricart Antoni, Ventura Josep-Lluis, Pagès Teresa, Javierre Casimiro, Viscor Ginés, Segura Ramon   +7 more
doaj   +1 more source

Sex‐related differences in the peripheral vascular response to hypoxia: Implications in health and relevance for obstructive sleep apnoea

Experimental Physiology, EarlyView.
Abstract The incidence and presentation of obstructive sleep apnoea, as well as hypertension and cardiovascular disease, have been reported to differ by sex. It is thus reasonable to propose mechanisms contributing to subsequent pathology differ by sex. This concept is supported from a pre‐pathological perspective, as sex differences have been observed
Dain W. Jacob, Sara E. Mascone, Natasha G. Boyes, Anna M. Gonsalves, Jacqueline K. Limberg   +4 more
wiley   +1 more source